Juan Chen

发表

Blocking of STAT-3/SREBP1-mediated glucose-lipid metabolism is involved in dietary phytoestrogen-inhibited ovariectomized-induced body weight gain in rats.

Yuan Li, Zhong Li, Mengying Teng, 2018, The Journal of nutritional biochemistry.

Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling.

Yuan Li, Zhong Li, Mengying Teng, 2018, Chinese journal of natural medicines.

Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study

Tao Yang, Xuqin Zheng, Jing Zhu, 2020, Clinical Drug Investigation.

The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.

Yuan Li, Zhong Li, Chunyan Hu, 2016, Toxicology letters.

The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells

Yuan Li, Zhong Li, Yun Liu, 2017, BMC Cancer.

Effects of CYP3A4*1G and CYP3A5*3 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects

Guangji Wang, Yun Liu, J. Aa, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Yun Hu, Wenxia Cui, Weihong Zhou, 2018, Endocrine journal.

A double‐blind, randomized, placebo and positive‐controlled study in healthy volunteers to evaluate pharmacokinetic and pharmacodynamic properties of multiple oral doses of cetagliptin

Jinsong Ding, Feng Shao, Jinmiao Lu, 2021, British journal of clinical pharmacology.

GLP-1RA promotes brown adipogenesis of C3H10T1/2 mesenchymal stem cells via the PI3K-AKT-mTOR signaling pathway.

Yun Hu, Juan Chen, Xiaoqin Zhao, 2018, Biochemical and biophysical research communications.

Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study

Zhuanxia Zhang, Feng Shao, Juan Chen, 2022, Frontiers in Pharmacology.

A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [14C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers

Yun Liu, Feng Shao, Juan Chen, 2017, Cancer Chemotherapy and Pharmacology.

Pharmacokinetics, Safety and Tolerability of Tylerdipine Hydrochloride, a Novel Dihydropyridine Dual L/T-type Calcium Channel Blocker, after Single and Multiple Oral Doses in Healthy Chinese Subjects

Yun Liu, Feng Shao, Juan Chen, 2018, Clinical Drug Investigation.

Subclinical hyperthyroidism increases risk of coronary heart disease events in type 2 diabetes mellitus

W. Lu, Tingting Hu, Bingjian Wang, 2015, Endocrine.

High Mobility Group Box1 Inhibitor Glycyrrhizic Acid Attenuates Kidney Injury in Streptozotocin-Induced Diabetic Rats

Xiangcheng Zhang, Hong Zhang, Juan Chen, 2017, Kidney and Blood Pressure Research.

First-in-Human, Single-Ascending Dose and Food Effect Studies to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Cetagliptin, a Dipeptidyl Peptidase-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Sijia Ding, H. Shen, Feng Shao, 2021, Clinical Drug Investigation.

The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells.

Yuan Li, Zhong Li, Mengying Teng, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3.

Yuan Li, Zhong Li, Chunyan Hu, 2017, Environmental toxicology and pharmacology.

Metabolic disposition of [14C]‐abivertinib, an epidermal growth factor receptor tyrosine kinase inhibitor: Role of glutathione conjugation

Mingshe Zhu, R. Guo, Y. Shu, 2020, British journal of clinical pharmacology.

Impact of Gastric H+/K+-ATPase rs2733743 on the Intragastric pH-Values of Dexlansoprazole Injection in Chinese Subjects

Yun Fang, Hao Li, Yong-Qing Wang, 2017, Front. Pharmacol..

Safety, pharmacokinetics, and pharmacodynamics of S-(−)-pantoprazole sodium injections after single and multiple intravenous doses in healthy Chinese subjects

Lei Yu, Yong-Qing Wang, Ling Meng, 2018, European Journal of Clinical Pharmacology.

A chiral LC-MS/MS method for the enantioselective determination of R-(+)- and S-(-)-pantoprazole in human plasma and its application to a pharmacokinetic study of S-(-)-pantoprazole sodium injection.

Luning Sun, Juan Chen, Hong-wen Zhang, 2017, Biomedical chromatography : BMC.

The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells

Yuan Li, Zhong Li, Yun Liu, 2017, BMC Cancer.

Effects of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Proton Pump Inhibitors.

Yun Liu, Yong-Qing Wang, Luning Sun, 2019, Pharmacological research.

Mass balance, metabolic disposition, and pharmacokinetics of [14C]ensartinib, a novel potent anaplastic lymphoma kinase (ALK) inhibitor, in healthy subjects following oral administration

Wei Liu, Sijia Ding, Lingling Zhang, 2020, Cancer Chemotherapy and Pharmacology.

GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats.

Xiangcheng Zhang, Hong Zhang, Xiaoning Liu, 2018, International journal of molecular medicine.

Pharmacokinetics, Tolerability, Safety, and Immunogenicity of LY01008 and Bevacizumab (Avastin®) in Healthy Chinese Subjects

Sijia Ding, Feng Shao, Juan Chen, 2022, European Journal of Drug Metabolism and Pharmacokinetics.

Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of SY-004, a Glucokinase Activator, in Healthy Chinese Adults: A Randomized, Phase Ia, Single-Ascending Dose Study.

Yun Liu, Feng Shao, Juan Chen, 2022, Clinical therapeutics.

Isoliquiritigenin attenuates MiR-21 expression via induction of PIAS3 in breast cancer cells

Zhong Li, Yun Liu, Shilong Ning, 2017 .

Serum Elabela/Toddler Levels Are Associated with Albuminuria in Patients with Type 2 Diabetes

D. Gong, Xiangcheng Zhang, Hong Zhang, 2018, Cellular Physiology and Biochemistry.

Absorption, metabolism, excretion, and safety of [14C]almonertinib in healthy Chinese subjects

Wei Liu, Sijia Ding, Lingling Zhang, 2021, Annals of translational medicine.

Elevated expression levels of serum insulin‐like growth factor‐1, tumor necrosis factor‐α and vascular endothelial growth factor 165 might exacerbate type 2 diabetic nephropathy

Juan Chen, Xiang Li, Wen-bing Qiu, 2016, Journal of diabetes investigation.

Safety, Pharmacokinetics, and Pharmacodynamics of Midazolam Gel After Rectal Administration in Healthy Chinese Subjects

Sijia Ding, Aiping Zheng, Feng Shao, 2023, Clinical Drug Investigation.

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Evaluate the Absorption of Midazolam Rectal Gel.

Sijia Ding, Feng Shao, Juan Chen, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacokinetics of ginkgolides A, B and K after single and multiple intravenous infusions and their interactions with midazolam in healthy Chinese male subjects

Yun Liu, Yunsu Ma, W. Xiao, 2017, European Journal of Clinical Pharmacology.

Tolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects

Yun Liu, Feng Shao, Juan Chen, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

A Randomized, Open‐Label, Crossover Phase 1 Study to Evaluate the Effects of Food on the Pharmacokinetics of a Single Oral Dose of a 15‐mg Tylerdipine Tablet in Healthy Chinese Male Volunteers

Yan-li Zhou, Yun Liu, Feng Shao, 2018, Clinical pharmacology in drug development.

Development and validation of two LC-MS/MS methods to assay urinary tylerdipine hydrochloride and its metabolites in healthy Chinese subjects.

Guangji Wang, Yun Liu, J. Aa, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Bioequivalence Study of 2 Formulations of Rivaroxaban, a Narrow‐Therapeutic‐Index Drug, in Healthy Chinese Subjects Under Fasting and Fed Conditions

W. Deng, Yun Liu, Sijia Ding, 2020, Clinical pharmacology in drug development.

GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats.

Xiangcheng Zhang, Hong Zhang, Xiaoning Liu, 2018, International journal of molecular medicine.

Simultaneous quantification of antofloxacin and its major metabolite in human urine by HPLC-MS/MS, and its application to a pharmacokinetic study.

Yun Liu, Mao Huang, Yunsu Ma, 2017, Biomedical chromatography : BMC.