M. Missbach

发表

Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.

J. Saurat, M. Becker‐André, C. Carlberg, 1997, The Journal of Biological Chemistry.

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

C. Jerome, M. Missbach, R. Gamse, 2011, Osteoporosis International.

Src inhibitors: drugs for the treatment of osteoporosis, cancer or both?

M. Missbach, J. Green, M. Susva, 2000, Trends in pharmacological sciences.

Glial Cell-Line Derived Neurotrophic Factor-Mediated RET Signaling Regulates Spermatogonial Stem Cell Fate1

J. Saurat, M. Becker‐André, C. Carlberg, 2006, Biology of reproduction.

Enantioselective Saponification with Pig Liver Esterase (PLE): (1S,2S,3R)‐3‐Hydroxy‐2‐nitrocyclohexyl Acetate

D. Seebach, M. Missbach, M. Eberle, 2003 .

Phenothiazines are potent inhibitors of osteoclastic bone resorption.

T. J. Hall, M. Missbach, M. Schaeublin, 1996, General pharmacology.

N(7)-substituted-5-aryl-pyrrolo[2,3-d]pyrimidines represent a versatile class of potent inhibitors of the tyrosine kinase c-Src.

E. Altmann, L. Widler, M. Missbach, 2002, Mini reviews in medicinal chemistry.

Active recombinant human tyrosine kinase c-Yes: expression in baculovirus system, purification, comparison to c-Src, and inhibition by a c-Src inhibitor.

M. Šuša, G. Mcmaster, M. Missbach, 2000, Protein expression and purification.

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

E. Altmann, Jonathan R. Green, C. Betschart, 2007, Journal of medicinal chemistry.

[3 + 3]-Carbocyclizations of nitroallylic esters and enamines with stereoselective formation of up to six new stereogenic centers

D. Seebach, M. Missbach, M. Eberle, 1990 .

Thiazolidine Diones, Specific Ligands of the Nuclear Receptor Retinoid Z Receptor/Retinoid Acid Receptor-related Orphan Receptor α with Potent Antiarthritic Activity*

C. Carlberg, I. Wiesenberg, M. Missbach, 1996, The Journal of Biological Chemistry.

Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.

C. Carlberg, M. Chiesi, C. Spanka, 1998, Molecular pharmacology.

Novel scaffold for cathepsin K inhibitors.

O. Ohmori, S. Cowan-Jacob, K. Masuya, 2007, Bioorganic & medicinal chemistry letters.

Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand.

C. Carlberg, M. Schräder, I. Wiesenberg, 1995, Nucleic acids research.

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

E. Altmann, S. Cowan-Jacob, M. Missbach, 2004, Journal of medicinal chemistry.

Dipeptide nitrile inhibitors of cathepsin K.

E. Altmann, Jonathan R. Green, C. Betschart, 2006, Bioorganic & medicinal chemistry letters.

A solid-phase assay for the determination of protein tyrosine kinase activity of c-src using scintillating microtitration plates.

K. Lipson, M. Missbach, M. Sills, 1996, Analytical biochemistry.

The potential role of the transcription factor RZR/ROR as a mediator of nuclear melatonin signaling.

C. Carlberg, I. Wiesenberg, M. Missbach, 1998, Restorative neurology and neuroscience.

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.

M. Šuša, J. Green, J. Feyen, 1999, Bone.

Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys

C. Jerome, M. Missbach, R. Gamse, 2011, Osteoporosis International.

7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.

E. Altmann, M. Šuša, J. Green, 2001, Bioorganic & medicinal chemistry letters.

Evidence that c-src is involved in the process of osteoclastic bone resorption.

T. J. Hall, M. Missbach, M. Schaeublin, 1994, Biochemical and biophysical research communications.

Src as a Target for Pharmaceutical Intervention

M. Šuša, T. O'reilly, A. Teti, 2006 .

1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists.

E. Altmann, R. Wolf, K. Seuwen, 2010, Journal of medicinal chemistry.

European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe **

A. Torrens, M. Bossart, Michael Wagner, 2023, ChemMedChem.

7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.

E. Altmann, M. Šuša, J. Green, 2001, Bioorganic & medicinal chemistry letters.

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.

E. Altmann, M. Šuša, J. Green, 2000, Bioorganic & medicinal chemistry letters.

Tyrosine kinase inhibition in bone metabolism.

E. Altmann, M. Šuša, M. Missbach, 2000, Current opinion in drug discovery & development.