Staffan Karlsson

发表

From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations

Rebecca E. Meadows, G. Currie, H. Emtenäs, 2021, Organic Process Research & Development.

A mild hydrolysis of esters mediated by lithium salts

Mikael Dahlström, Staffan Karlsson, Sara Mattsson, 2007 .

Development of a Safe Continuous Manufacturing Route to 2-(4-Isopropyl-1H-1,2,3-triazol-1-yl)acetic Acid

H. Emtenäs, C. Cook, Staffan Karlsson, 2017 .

Using Oxygen as the Primary Oxidant in a Continuous Process: Application to the Development of an Efficient Route to AZD4635

Matthew L Jones, Eleonora Fava, Staffan Karlsson, 2022, Organic Process Research & Development.

Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.

A. Åstrand, A. Wallberg, N. Selmi, 2013, Bioorganic & medicinal chemistry letters.

Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRASG12C Inhibitors

H. Emtenäs, Anna-Carin C. Carlsson, C. Cook, 2021, Organic Process Research & Development.

Route Optimization and Manufacture of Multihundred Grams of a Ghrelin Receptor Agonist

Cristina Gardelli, Staffan Karlsson, G. Nikitidis, 2018, Organic Process Research & Development.

ASYMMETRIC 1,3-DIPOLAR CYCLOADDITIONS FOR THE CONSTRUCTION OF ENANTIOMERICALLY PURE HETEROCYCLES. A REVIEW

H. Högberg, Staffan Karlsson, 2001 .

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability.

J. Kihlberg, F. Bergström, G. Grönberg, 2016, Journal of medicinal chemistry.

A One-Pot Asymmetric Synthesis of a N-Acylated 4,5-Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165

Staffan Karlsson, J. Bran̊alt, M. O. Halvarsson, 2014 .

trans-3,4-Disubstituted pyrrolidines by 1,3-dipolar cycloaddition: enantioselective approaches and their limitations

Fusen Han, H. Högberg, Staffan Karlsson, 1999 .

Evaluation and Development of Practical Routes to an Enantiomerically Pure C2-Symmetric Diamine Building Block

J. Lindberg, H. Sørensen, Staffan Karlsson, 2013 .

A Scalable Route to 5-Substituted 3-Isoxazolol Fibrinolysis Inhibitor AZD6564

Martin Bollmark, H. Sørensen, Staffan Karlsson, 2014 .

A Practical Telescoped Three-Step Sequence for the Preparation of (1R,2R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects

Peter R. Moore, H. Emtenäs, J. Broddefalk, 2018 .

Chiral pyrrolidinium salts as organocatalysts in the stereoselective 1,4-conjugate addition of N-methylpyrrole to cyclopent-1-ene carbaldehyde

E. Hedenström, Palle Breistein, Staffan Karlsson, 2006 .

Organocatalysts Promote Enantioselective 1,3‐Dipolar Cycloadditions of Nitrones with 1‐Cycloalkene‐1‐carboxaldehydes

H. Högberg, Staffan Karlsson, 2003 .

Catalytic enantioselective 1,3-dipolar cycloaddition of nitrones to cyclopent-1-enecarbaldehyde

H. Högberg, Staffan Karlsson, 2002 .

Selection and Development of a Route for Cholesterol Absorption Inhibitor AZD4121

Staffan Karlsson, J. Sörensen, 2012 .

Enantiomerically Pure trans-3,4-Disubstituted Tetrahydrothiophenes from Diastereoselective Thiocarbonyl Ylide Addition to Chiral α,β-Unsaturated Amides

H. Högberg, Staffan Karlsson, 1999 .

Development of a Large-Scale Route to an MCH1 Receptor Antagonist: Investigation of a Staudinger Ketene–Imine Cycloaddition in Batch and Flow Mode

Peter R. Moore, H. Sørensen, Staffan Karlsson, 2015 .

Diastereoselective addition of chiral azomethine ylides to cyclic α,β-unsaturated N-enoylbornanesultams

H. Högberg, Staffan Karlsson, 2002 .

Diastereoselective addition of chiral azomethine ylides to cinnamoyl moieties, attached to chiral auxiliaries

H. Högberg, Staffan Karlsson, 2001 .

Synthesis of enantiomerically pure 4-substituted pyrrolidin-3-ols via asymmetric 1,3-dipolar cycloaddition

H. Högberg, Staffan Karlsson, 2001 .

A Scalable High‐Yielding and Selective Oxidative Heck Cross‐Coupling – A Key Step for the Synthesis of trans‐ Stilbenes

D. Cirillo, H. Bjørsvik, Staffan Karlsson, 2021, European Journal of Organic Chemistry.

Approaches to Synthesis and Isolation of Enantiomerically Pure Biologically Active Atropisomers.

Rachel Munday, Anna-Carin C. Carlsson, Staffan Karlsson, 2022, Accounts of chemical research.

An Enantioselective Hydrogenation of an Alkenoic Acid as a Key Step in the Synthesis of AZD2716

Staffan Karlsson, Henrik Toft Sørensen, Søren M. Andersen, 2016 .

Sex Pheromone of the Pine Sawfly, Macrodiprion nemoralis. Stereoselective Synthesis of the Sixteen Stereoisomers of 3,7,9‐Trimethyl‐2‐tridecyl Acetate.

E. Hedenstroem, Staffan Karlsson, 1999 .

Using Spinchem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case Study

H. Emtenäs, C. Öberg, Staffan Karlsson, 2019, Organic Process Research & Development.

Development of an Enantioselective Novozym 435 Mediated Acetylation for the Preparation of (1S,3R)-3-Acetamidocyclohexane-1-carboxylic Acid

Staffan Karlsson, 2016 .

Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.

S. Winiwarter, J. Ulander, Malin Lemurell, 2019, Journal of medicinal chemistry.

Synthesis of butenolides recently isolated from marine microorganisms

E. Hedenström, F. Andersson, Palle Breistein, 2007 .

Pheromones of Pine Sawflies: Synthesis of a Pure (2S,3R)-3-Methylalkan-2-ol Stereoisomer via an Asymmetric 1,3-Dipolar Cycloaddition; Preparation of a Pheromone Component of Macrodiprion nemoralis

H. Högberg, Staffan Karlsson, 2000 .

Sex Pheromone of the Pine Sawfly Macrodiprion nemoralis : Stereoselective Synthesis of the Sixteen Stereoisomers of 3,7,9-Trimethyl-2-tridecyl Acetate

E. Hedenström, Staffan Karlsson, 1999 .