D. Duch

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Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW 301U), a novel lipid-soluble inhibitor of dihydrofolate reductase.

M. Edelstein, C. A. Nichol, D. Duch, 1982, Cancer research.

Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo.

M. Edelstein, C. A. Nichol, D. Duch, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Clinical experience with leucovorin and 5‐fluorouracil

R. Ferone, M. Collier, V. B. Knick, 1989, Cancer.

Clinical experience with CF-FUra.

R. Ferone, M. Collier, V. B. Knick, 1988, Advances in experimental medicine and biology.

Potentiation of radiation therapy by vinorelbine (Navelbine) in non-small cell lung cancer.

M. Edelstein, D. Duch, L. Wolfe, 1996, Seminars in oncology.

Preclinical Drug Discovery and Development

D. Duch, R. Ferris, 2002 .

In vivo measurement of dihydrofolate reductase and its inhibition by antifolates.

D. Duch, S. W. Bowers, 1988, Analytical biochemistry.

Utilization of dihydroflavin mononucleotide and superoxide anion for the decyclization of L-tryptophan by murine epididymal indoleamine 2,3-dioxygenase.

Y. Ozaki, C. A. Nichol, D. Duch, 1987, Archives of biochemistry and biophysics.

Benzoquinazoline Inhibitor of Thymidylate Synthase Biochemical and Cellular Pharmacology of 1843 U 89 , a Novel Updated

Pendergast, Kathleen, J. Humphreys, 2006 .

Endogenous inhibitor(s) in adrenal medulla of dopamine-ß-hydroxylase☆

O. H. Viveros, N. Kirshner, D. Duch, 1968 .

Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.

R. Ferone, M. Hanlon, M. Edelstein, 1990, Journal of medicinal chemistry.

Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.

M. Edelstein, C. A. Nichol, D. Duch, 1983, Molecular pharmacology.

Biosynthesis and function of tetrahydrobiopterin

Gary K. Smith, D. Duch, 1991 .

Differences in the metabolism of the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in mutant mice with neurological and immunological defects

L. Maltais, M. Davisson, C. A. Nichol, 1986, Biochemical Genetics.

Distribution and metabolism of calcium leucovorin in normal and tumor tissue.

R. Mullin, B. Keith, D. Duch, 1988, Advances in experimental medicine and biology.

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

M. Edelstein, Y. Ozaki, D. Duch, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The actions of interferon and antiinflammatory agents of induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes.

M. Edelstein, Y. Ozaki, D. Duch, 1987, Biochemical and biophysical research communications.

Effect of purine synthesis inhibition on WiDr spheroids in vitro or on WiDr or colon 38 tumors in vivo. Complete growth inhibition but not regression.

J. Stables, R. Mullin, V. Knick, 1994, Biochemical pharmacology.

Urinary biopterin and neopterin excretion and pituitary-adrenal activity in psychiatric patients

J. Garbutt, C. A. Nichol, D. Duch, 1985, Psychiatry Research.

Urinary excretion of bioterin and neopterin in psychiatric disorders

J. Davidson, J. Garbutt, C. A. Nichol, 1984, Psychiatry Research.

Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity.

C. Bacchi, M. Edelstein, C. A. Nichol, 1984, Biochemical pharmacology.

Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase.

C. A. Nichol, D. Duch, S. W. Bowers, 1978, Biochemical pharmacology.

Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex.

O. H. Viveros, M. Abou-donia, C. A. Nichol, 1983, Endocrinology.

In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues.

R. Ferone, R. Mullin, B. Keith, 1992, Biochemical pharmacology.

New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines.

M. Edelstein, E. Bigham, G. K. Smith, 1992, The Journal of biological chemistry.

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

S. Lee, C. A. Nichol, D. Duch, 1980, Journal of medicinal chemistry.

Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.

R. Ferone, J. Humphreys, R. Kisliuk, 1991, Journal of medicinal chemistry.

Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.

R. Ferone, S. Dickerson, W. Pendergast, 1994, Journal of medicinal chemistry.

Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.

R. Ferone, S. Dickerson, W. Pendergast, 1993, Journal of medicinal chemistry.

Lipophilic Inhibitors of Dihydrofolate Reductase

C. A. Nichol, D. Duch, C. W. Sigel, 1984 .

SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,4‐DIAMINO‐6‐(2,5‐DIMETHOXYBENZYL)‐5‐METHYLPYRIDO(2,3‐D)PYRIMIDINE

Shuliang Lee, C. A. Nichol, D. Duch, 1980 .

Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones.

R. Ferone, J. Humphreys, J. Kelly, 1993, Journal of medicinal chemistry.

Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.

R. Ferone, F. Maley, J. Galivan, 1989, Journal of medicinal chemistry.

Isolation and partial characterization of an endogenous inhibitor of dopamine-β-hydroxylase

N. Kirshner, D. Duch, 1971 .

Study on urine polyelectrolytes of cats with natural and experimental urolithiasis.

D. Hamar, F. C. Chow, L. D. Lewis, 1978, Biochemical medicine.

Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin.

G. K. Smith, C. A. Nichol, D. Duch, 1985, Annual review of biochemistry.

Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species.

C. A. Nichol, D. Duch, S. W. Bowers, 1984, Life sciences.

Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.

R. Ferone, E. Bigham, G. K. Smith, 1994, Journal of medicinal chemistry.

Thienyl and Thiazolyl Acyclic Analogues of 5‐Deazatetrahydrofolic Acid.

Gary K. Smith, E. Bigham, D. Duch, 1994 .

Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice.

S. Hutner, C. Bacchi, C. A. Nichol, 1981, Biochemical pharmacology.

Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.

R. Ferone, E. Bigham, W. Mallory, 1992, Journal of medicinal chemistry.

Multisubstrate Analogue Inhibitors of Glycinamide Ribonucleotide Transformylase Based on 5-Deazaacyclo Tetrahudrofolate (5-DACTHF)

R. Ferone, Gary K. Smith, E. Bigham, 1993 .

Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.

R. Ferone, J. Humphreys, Gary K. Smith, 1993, Cancer research.

Identification of both termini of an oligonucleotide in a nanomole quantity.

M. Laskowski, L. Stasiuk, D. Duch, 1973, Analytical biochemistry.

Synchronization of cells in the S phase of the cell cycle by 3′-azido-3′-deoxythymidine: implications for cell cytotoxicity

Bangaru Chandrasekaran, T. Kute, Timothy E. Kute, 2004, Cancer Chemotherapy and Pharmacology.

A Comparison of Hplc and Ternary Complex-Based Assays of Tissue Reduced Folates

D. Priest, M. Bunni, M. Rhee, 1992 .

Metabolic effects and kill of human T-cell leukemia by 5-deazaacyclotetrahydrofolate, a specific inhibitor of glycineamide ribonucleotide transformylase.

S. Kaufmann, G. K. Smith, D. Duch, 1992, Cancer research.

Analysis of folate cofactor levels in tissues using high-performance liquid chromatography.

C. A. Nichol, D. Duch, S. W. Bowers, 1983, Analytical biochemistry.

Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth.

D. Bigner, C. A. Nichol, D. Duch, 1979, Cancer research.

Activity of an NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells.

R. Rigual, T. Monaco, R. Mullin, 1990, Archives of biochemistry and biophysics.

A sensitive high-performance liquid chromatographic-fluorometric assay for dihydrofolate reductase in adult rat brain, using 7,8-dihydrobiopterin as substrate.

J. Reinhard, G. K. Smith, C. A. Nichol, 1984, Analytical biochemistry.

Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists.

M. Edelstein, C. A. Nichol, D. Duch, 1980, Molecular pharmacology.

Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.

R. Ferone, M. Edelstein, R. Kisliuk, 1989, Journal of medicinal chemistry.

Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid.

M. Hanlon, B. Shane, J. Freisheim, 1991, Biochemical pharmacology.

Direct demonstration of the active salvage of preformed purines by murine tumors.

S. Benkovic, D. Johnson, R. Mullin, 1990, Biochemical and biophysical research communications.

The role of tryptophan and kynurenine transport in the catabolism of tryptophan through indoleamine 2,3-dioxygenase.

M. Salter, Richard Graham Knowles, C. I. Pogson, 1991, Advances in experimental medicine and biology.

Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.

R. Ferone, C. M. Boytos, H. R. Wilson, 1995, Cancer research.

Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate.

O. H. Viveros, M. Edelstein, C. A. Nichol, 1986, Endocrinology.

Endocrine-dependent regulation of tetrahydrobiopterin levels and guanosine triphosphate cyclohydrolase activity

C. A. Nichol, D. Duch, S. W. Bowers, 1986, Molecular and Cellular Endocrinology.

Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography.

C. A. Nichol, D. Duch, J. Woolf, 1983, Journal of Chromatography A.

A sensitive method for the determination of RNA in DNA and vice versa.

M. Laskowski, D. Duch, 1971, Analytical biochemistry.