K. Madela

发表

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

C. Mcguigan, K. Madela, C. Mcguigan*, 2012, Future medicinal chemistry.

Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

E. Gorovits, A. Kolykhalov, Srinivas K. Battina, 2011, Journal of medicinal chemistry.

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

J. Neyts, C. Mcguigan, K. Madela, 2009, Bioorganic & medicinal chemistry letters.

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties

E. Gorovits, Yule Liu, A. Kolykhalov, 2011, Antimicrobial Agents and Chemotherapy.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

E. Gorovits, Yule Liu, A. Kolykhalov, 2010, Journal of medicinal chemistry.

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.

E. Gorovits, A. Brancale, A. Kolykhalov, 2010, Bioorganic & medicinal chemistry letters.

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

A. Kolykhalov, Srinivas K. Battina, J. Vernachio, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of Phosphoramidate Prodrugs: ProTide Approach

K. Madela, Magdalena Ślusarczyk, F. Pertusati, 2013, Current protocols in nucleic acid chemistry.

Pharmacodynamic Properties Replication with Excellent Pharmacokinetic Potent Inhibitor of Hepatitis C Virus-Methyl Guanosine , Is a C-′-Methyl-2 O 6-INX-08189 , a Phosphoramidate Prodrug of

E. Gorovits, Yule Liu, A. Kolykhalov, 2011 .

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

A. Kolykhalov, L. Margolis, J. Balzarini, 2013, European Journal of Medicinal Chemistry.