Yueheng Jiang

发表

I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.

B. Feld, R. Palermo, J. Duca, 2011, Bioorganic & medicinal chemistry letters.

III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.

James W. Hall, J. Baldwin, C. Carroll, 2011, Bioorganic & medicinal chemistry letters.

Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV.

E. Asante-Appiah, M. Dwyer, A. Nomeir, 2018, Bioorganic & medicinal chemistry letters.

IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: improved PK, hERG and metabolic profiles.

C. Carroll, D. Hobbs, B. Mcguinness, 2014, Bioorganic & medicinal chemistry letters.

Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.

F. G. Njoroge, K. Cheng, S. Agrawal, 2014, ACS medicinal chemistry letters.

Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.

J. Duca, F. G. Njoroge, S. Agrawal, 2014, Bioorganic & medicinal chemistry.

Discovery of potent macrocyclic HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.

M. Dwyer, A. Nomeir, R. Mazzola, 2016, Bioorganic & medicinal chemistry letters.

Discovery of an irreversible HCV NS5B polymerase inhibitor.

J. Gesell, J. Duca, F. G. Njoroge, 2013, Bioorganic & medicinal chemistry letters.

Stereoselective total synthesis of antitumor macrolide (+)-rhizoxin D.

Jian Hong, Yueheng Jiang, S. D. Burke, 2004, Organic letters.

Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists.

Walter A. Korfmacher, J. Hey, R. Aslanian, 2013, Bioorganic & Medicinal Chemistry Letters.

Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Alkyl substituted aminal derivatives of HCV NS5A inhibitor MK-8742.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

Determination of the Activation Parameters for the Bergman Cyclization of Aromatic Enediynes

Yueheng Jiang, Heidi A. McMillen, J. Grissom, 1994 .

Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.

James I. Fells, E. Asante-Appiah, C. Coburn, 2016, Bioorganic & medicinal chemistry letters.

Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.

Xiaohong Zhu, Matthew Bryant, Xiaohong Zhu, 2002, Bioorganic & medicinal chemistry letters.

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.

J. Duca, F. G. Njoroge, S. Agrawal, 2013, Bioorganic & medicinal chemistry.

II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.

James W. Hall, C. Carroll, D. Hobbs, 2011, Bioorganic & medicinal chemistry letters.

Abstract 5776: Pharmacologic and PK/PD study of D-0502: An orally bioavailable SERD with potent antitumor activity in ER-positive breast cancer cell lines and xenograft models

Yaolin Wang, Zhe Shi, Xing Dai, 2018, Experimental and Molecular Therapeutics.

D‐1553: A novel KRASG12C inhibitor with potent and selective cellular and in vivo antitumor activity

Qing-Fang Zhu, Rongfeng Liu, Hong Yang, 2023, Cancer science.

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.

E. Asante-Appiah, C. Coburn, M. Dwyer, 2016, Bioorganic & medicinal chemistry letters.

II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.

Frank Bennett, Charles A Lesburg, Sony Agrawal, 2011, Bioorganic & medicinal chemistry letters.