Hui Li

发表

Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges.

S. Shi, Hui Li, 2010, Future medicinal chemistry.

Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.

Qihua Zhu, Yungen Xu, Hui Li, 2016, Bioorganic & medicinal chemistry.

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

C. Lewis, S. Shi, S. Binford, 2009, Antimicrobial Agents and Chemotherapy.

In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

M. Hickey, H. Parge, C. Lewis, 2007, Antimicrobial Agents and Chemotherapy.

Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein

Shuwen Liu, Gaopeng Song, Yan Wu, 2022, European Journal of Medicinal Chemistry.

Structure-based discovery of new maternal embryonic leucine zipper kinase inhibitors.

J. Bao, L. Zhong, Xin Long, 2018, Organic and biomolecular chemistry.

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.

D. Bouzida, Iriny Botrous, G. Alton, 2011, Bioorganic & medicinal chemistry letters.

Developments of DNA-dependent Protein Kinase Inhibitors as Anticancer Agents.

Hui Li, Chen-Chen Ma, Ren-zhong Wan, 2014, Mini reviews in medicinal chemistry.

Orevactaene,1 a novel binding inhibitor of HIV-1 Rev protein to Rev response element (RRE) from Epicoccum nigrum WC47880

Stella Huang, Y. Shu, K. Kodukula, 1997 .

Discovery of Novel Dual Poly(ADP-ribose)polymerase (PARP) and Phosphoinositide 3-kinase (PI3K) Inhibitors as A Promising Strategy for Cancer Therapy.

Qihua Zhu, Zhaoxing Chu, Yiran Ge, 2019, Journal of medicinal chemistry.

Discovery of pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D (KDM4D) inhibitors.

Lin-Li Li, Sheng-yong Yang, Jun Zou, 2017, Bioorganic & medicinal chemistry letters.

Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease: room-temperature X-ray and neutron crystallography, binding thermodynamics, and antiviral activity

J. Louis, P. Bonnesen, K. Weiss, 2022, Research square.

Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors.

Qihua Zhu, Yiran Ge, Yungen Xu, 2021, Bioorganic & medicinal chemistry letters.

Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.

Hui Li, Xiu Yu, M. Hickey, 2009, Journal of medicinal chemistry.

Imidazo[1,2-a]Pyridine Derivatives as Novel Dual-Target Inhibitors of ABCB1 and ABCG2 for Reversing Multidrug Resistance.

Hui Peng, Xiaoli Xu, Hui Li, 2023, Journal of medicinal chemistry.

Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease

J. Louis, A. Ramanathan, M. Head, 2021, Journal of medicinal chemistry.

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Qihua Zhu, Yi Zou, Yungen Xu, 2021, Molecules.

Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.

Qihua Zhu, Yiran Ge, Yungen Xu, 2020, European journal of medicinal chemistry.

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.

Hui Li, M. Hickey, P. Dragovich, 2006, Bioorganic & medicinal chemistry letters.

Identification of new p300 histone acetyltransferase inhibitors from natural products by a customized virtual screening method

Lin-Li Li, Sheng-yong Yang, Luyi Huang, 2016 .

Nitro-based inhibitors against thermolysin

Z. Zeng, G. Tian, Hui Li, 2011 .

Discovery of Potent Small Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-pancreatic Ductal Adenocarcinoma Activity.

Sheng-yong Yang, Linli Li, Hui Li, 2020, Journal of medicinal chemistry.

Virtual target screening reveals rosmarinic acid and salvianolic acid A inhibiting metallo- and serine-β-lactamases.

Yong Wu, Ling-Ling Yang, Shan Liu, 2018, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.

K. Liu, P. Tran, P. Wells, 2010, European journal of pharmacology.

Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.

Qihua Zhu, Yuyan Li, Yungen Xu, 2016, Bioorganic & medicinal chemistry letters.

Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.

P. Brennan, Sheng-yong Yang, Luyi Huang, 2019, Journal of medicinal chemistry.

Protein kinase C: novel isozyme-selective peptide inhibitors

Hui Li, 2006, Expert opinion on therapeutic patents.