F. Akahoshi

发表

Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones.

M. Nakajima, T. Imada, M. Miyazaki, 2001, Bioorganic & medicinal chemistry.

Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.

S. Takai, Y. Inoue, N. Shiota, 1998, Bioorganic & medicinal chemistry letters.

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.

S. Takai, Y. Inoue, N. Shiota, 1998, Bioorganic & medicinal chemistry letters.

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

H. Utsumi, S. Kiuchi, Yoshinobu Nakamaru, 2012, Bioorganic & medicinal chemistry.

Tissue distribution of teneligliptin in rats and comparisons with data reported for other dipeptidyl peptidase‐4 inhibitors

Yoshinobu Nakamaru, Noriko Hisanaga, T. Kume, 2016, Biopharmaceutics & drug disposition.

Highly diastereoselective coupling reaction of cyclopentenol derivatives by palladium catalyst

F. Akahoshi, S. Torii, H. Okumoto, 1989 .

Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia.

H. Nishimura, F. Akahoshi, C. Fukaya, 1996, Journal of medicinal chemistry.

Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives.

F. Akahoshi, C. Fukaya, M. Sugiura, 1994, Journal of medicinal chemistry.

Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.

K. Takedomi, Y. Onda, H. Shimizu, 2018, Journal of medicinal chemistry.

Synthesis and pharmacological activity of triazolo[1,5-a]triazine derivatives inhibiting eosinophilia.

Y. Inoue, T. Imagawa, H. Nishimura, 1998, Journal of medicinal chemistry.

Lead optimization of [( S )-γ-(arylamino)prolyl]thiazolidine focused on γ-substituent: Indoline compounds as potent DPP-IV inhibitors

S. Ono, H. Sakashita, H. Kitajima, 2007 .

Introduction of an Acetonyl Grouping at the C(3) Position of 2,3-Dehydropiperidine via Rearrangement of (β-Aminocyclopropyl)carbonyl Intermediate

T. Inokuchi, F. Akahoshi, S. Torii, 1987 .

Regioselective Alkylation of Vinylogous N-Acyliminium Ion, Leading to 6-Alkyl-1,2,3,6-tetrahydropyridines, by Using Electrogenerated Acid (EG acid) as a Catalyst

K. Uneyama, T. Inokuchi, F. Akahoshi, 1987 .

Preparation and biological activity of 2-[4-(thiazol-2-yl)phenyl]propionic acid derivatives inhibiting cyclooxygenase.

T. Goto, S. Ono, F. Akahoshi, 1991, Chemical & pharmaceutical bulletin.

Palladium Catalyzed Alkenylation of 1-Siloxycyclopent-2-ene Leading to Enol Silyl Ether of 3-Alkenylcyclopentanones

F. Akahoshi, S. Torii, H. Okumoto, 1989 .

Highly Diastereoselective Coupling Reaction of Cyclopentenol Derivatives by Palladium Catalyst.

F. Akahoshi, S. Torii, H. Okumoto, 1990 .

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site.

Shinichi Ishii, Takashi Kadowaki, Ikuko Miyaguchi, 2013, Biochemical and biophysical research communications.

Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.

Hiroshi Sakashita, Yoshiharu Hayashi, Ikuko Miyaguchi, 2012, Bioorganic & medicinal chemistry.

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.

M. Nakajima, H. Sakashita, T. Imada, 2001, Journal of medicinal chemistry.

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.

M. Miyazaki, M. Eda, M. Nakajima, 2001, Journal of medicinal chemistry.

[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors.

H. Sakashita, H. Kitajima, F. Akahoshi, 2006, Bioorganic & medicinal chemistry.

H. Utsumi, S. Kiuchi, Yoshinobu Nakamaru, 2012, Bioorganic & medicinal chemistry.

A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site.

T. Kadowaki, F. Akahoshi, S. Ishii, 2013, Biochemical and biophysical research communications.

[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.

H. Sakashita, F. Akahoshi, Tomohiro Yoshida, 2007, Bioorganic & medicinal chemistry letters.

Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.

S. Ono, H. Sakashita, H. Kitajima, 2007, Bioorganic & medicinal chemistry.

1-((S)-gamma-substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors.

H. Sakashita, H. Kitajima, F. Akahoshi, 2005, Bioorganic & medicinal chemistry letters.