E. Raviña

发表

New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.

Ferran Sanz, Angelo Carotti, Antonio Carrieri, 2002, Journal of medicinal chemistry.

Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

M. Loza, J. Brea, C. Masaguer, 2011 .

Synthesis of substituted tetralones as intermediates of CNS agents via palladium-catalyzed cross-coupling reactions

C. Masaguer, E. Raviña, Marı́a Torrado, 2007 .

Preparation of (R)-(−)- and (S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs, via resolution of precursors

Yolanda Caro, C. Masaguer, E. Raviña, 2003 .

Kinetic resolution of 3-hydroxymethylbenzocycloalkanols by selective asymmetric hydrogen-transfer oxidation

Yolanda Caro, C. Masaguer, E. Raviña, 2003 .

New synthetic approaches to CNS drugs. A straightforward, efficient synthesis of tetrahydroindol-4-ones and tetrahydroquinolin-5-ones via palladium-catalyzed oxidation of hydroxyenaminones

C. Masaguer, E. Raviña, B. Pita, 2002 .

Pyridazine derivatives. Part 38: Efficient Heck alkenylation at position 5 of the 6-phenyl-3(2H)-pyridazinone system ☆

E. Sotelo, Alberto Coelho, N. Blaton, 2004 .

Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.

F. Sanz, M. Loza, J. Brea, 2008, Bioorganic & medicinal chemistry.

1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.

F. Sanz, M. Loza, J. Brea, 2008, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.

F. Sanz, M. Loza, E. Sotelo, 2006, Journal of medicinal chemistry.

8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.

M. Loza, E. Sotelo, M. Cadavid, 2004, European journal of medicinal chemistry.

Design , Synthesis , and Structure-Activity Relationships of 1-, 3-, 8-, and 9-Substituted-9-deazaxanthines at the Human A 2 B Adenosine Receptor

F. Sanz, M. Loza, E. Sotelo, 2022 .

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.

E. Sotelo, Alberto Coelho, M. Yáñez, 2004, Bioorganic & medicinal chemistry letters.

Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones.

E. Sotelo, M. Yáñez, E. Raviña, 2002, Chemical & pharmaceutical bulletin.

Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.

E. Sotelo, J. Brea, M. Yáñez, 2002, Bioorganic & medicinal chemistry letters.

Pyridazine derivatives XIV. Study of the vasorelaxant action of 6-aryl-5-piperidino-3-hydrazinopyridazines in isolated rat thoracic aorta: comparison with hydralazine.

F. Orallo, M. Campos-Toimil, E. Raviña, 1998, General pharmacology.

3-Oxopyridazin-5-yl-Chalcone Hybrids : Potent Antiplatelet Agents That Prevent Glycoprotein IIb/IIIa Activation

M. Loza, E. Sotelo, Alberto Coelho, 2017 .

New CNS agent precursors. A simple and efficient route for synthesis of 6-aminomethyl-4,5,6,7-tetrahydrobenzofuran-4-ones as conformationally constrained butyrophenone analogues

C. Masaguer, E. Raviña, I. Casariego, 1997 .

A practical and efficient route for synthesis of 6-aminomethyl-4-oxo-4,5,6,7-tetrahydroindoles as new CNS agent precursors

C. Masaguer, E. Raviña, 1996 .

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

E. Sotelo, Alberto Coelho, N. Blaton, 2004 .

Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones.

E. Sotelo, Alberto Coelho, E. Raviña, 2003, Chemical & pharmaceutical bulletin.

Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones☆

E. Sotelo, Alberto Coelho, E. Raviña, 2003 .

Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.

M. Loza, J. Brea, Yolanda Caro, 2004, Bioorganic & Medicinal Chemistry Letters.

Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: synthesis and determination of affinities at D(2), 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

M. Loza, J. Brea, C. Masaguer, 2000, European journal of medicinal chemistry.

Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.

M. Loza, C. Masaguer, H. Tristán, 1998, Bioorganic & medicinal chemistry letters.

New cyclic butyrophenone derivatives in the indole series as potential atypical antipsychotics. A simple and practical synthesis of 6-aminomethyl-tetrahydroindol-4-ones and their affinites for D2 and 5-HT2A receptors

C. Masaguer, J. A. Fontenla, E. Raviña, 1997 .

Butyrophenone analogues: Synthesis of 2-methyl-3-ethyl-5-aminoethyl-4,5,6,7-tetrahydroindol-4-ones, and their affinities for d1, d2 and 5-ht2a receptors

M. Loza, M. Cadavid, C. Masaguer, 1995 .

Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions.

E. Sotelo, M. Yáñez, E. Raviña, 2002, Bioorganic & medicinal chemistry.

Conformationally Restricted Butyrophenones with Mixed Dopaminergic (D2) and Serotoninergic (5-HT2A) Affinities. Synthesis of 5-Aminoethyl and 6-Aminomethyl-4-oxotetrahydroindoles as Potential Atypical Antipsychotics.

E. Raviña, I. Casariego, Chiristian F. Masaguer, 1999 .

Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives.

J. Calleja, C. Terán, F. Orallo, 1993, Journal of pharmaceutical sciences.

Corrigendum to “1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor” [Bioorg. Med. Chem. 16 (2008) 2852–2869]

F. Sanz, M. Loza, E. Sotelo, 2008 .

Pyridazine Derivatives. Part 21: Synthesis and Structural Study of Novel 4-Aryl-2,5-dioxo-8-phenylpyrido[2,3-d]pyridazines

E. Sotelo, M. Suárez, N. Blaton, 2000 .

Pyridazine Derivatives, VII. Synthesis and Hypotensive Activity of 3‐Hydrazinocycloalkyl[1,2‐c]pyridazines and their Derivatives

L. Santana, J. Calleja, C. Terán, 1989, Archiv der Pharmazie.

Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors.

E. Sotelo, E. Raviña, R. Laguna, 1997, Chemical & pharmaceutical bulletin.

Pyridazine derivatives XII. Synthesis and antipsychotic-antidepressant activity of some butyrophenone derivatives of 6-phenylpyridazine

M. Loza, M. Cadavid, M. L. Ceballos, 1994 .

Pyridazine Derivatives, VIII1): Synthesis and Antihypertensive Activity of 6‐(2‐Thienyl)‐5‐aminomethyl‐3‐hydrazino‐pyridazines

J. Calleja, C. Terán, F. Orallo, 1991, Archiv der Pharmazie.

PYRIDAZINE DERIVATIVES. IX, SYNTHESIS OF 2H-PYRIDAZIN-3-ONES WITH AROYLPIPERAZINYL GROUPS

L. Santana, C. Terán, E. Raviña, 1990 .

PYRIDAZINES. XV. SYNTHESIS OF 6-ARYL-5-AMINO-3(2H)-PYRIDAZINONES AS POTENTIAL PLATELET AGGREGATION INHIBITORS

E. Sotelo, E. Raviña, I. Estevez, 1998 .

Synthesis and Biological Evaluation of New Quinazoline and Cinnoline Derivatives as Potential Atypical Antipsychotics

C. Masaguer, Mario Alvarado, L. Carro, 2006, Chemistry & biodiversity.

PYRIDAZINE DERIVATIVES. XXIV.[1] EFFICIENT N-METHYLATION OF DIVERSELY SUBSTITUTED 3(2H)-PYRIDAZINONES USING N,N-DIMETHYLFORMAMIDE DIMETHYLACETAL

E. Sotelo, E. Raviña, 2002 .

Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids ☆

E. Sotelo, Alberto Coelho, E. Raviña, 2001 .

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2 H)-pyridazinones

E. Sotelo, Alberto Coelho, M. Yáñez, 2004 .

5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one.

E. Sotelo, M. Suárez, N. Blaton, 2000, Acta crystallographica. Section C, Crystal structure communications.

Study of the in vivo and in vitro cardiovascular effects of four new analogues of ketanserin: implication of 5-HT2A and alpha1 adrenergic antagonism in their hypotensive effect.

M. Loza, J. Calleja, F. Orallo, 2000, Biological & pharmaceutical bulletin.

Pyridazines. Part 34: Retro-ene-assisted palladium-catalyzed synthesis of 4,5-disubstituted-3(2H)-pyridazinones

E. Sotelo, Alberto Coelho, E. Raviña, 2003 .

Pyridazines. Part 25. Efficient and Selective Deprotection of Pharmacologically Useful 2-MOM-pyridazinones Using Lewis Acids.

E. Sotelo, Alberto Coelho, E. Raviña, 2002 .

Pyridazines. XVIII. 6-Aryl-3(2H)-pyridazinones inhibit calcium influx in stimulated platelets.

E. Raviña, R. Laguna, N. Fraiz, 1999, Biological & pharmaceutical bulletin.

Pyridazine derivatives. XIX: Functionalization studies at the 5 position in the 6‐phenyl‐3(2H)‐pyridazinone system

E. Sotelo, E. Raviña, I. Estevez, 1999 .

Pyridazine Derivatives. Part 24. Efficient N‐Methylation of Diversely Substituted 3(2H)‐Pyridazinones Using N,N‐Dimethylformamide Dimethylacetal.

E. Sotelo, E. Raviña, 2002 .

Pyridazines. Part 23. Efficient Arylation at Position 5 of the 6‐Phenyl‐(2H)‐pyridazin‐3‐one System Using a Suzuki Cross‐Coupling Reaction.

E. Sotelo, Alberto Coelho, E. Raviña, 2001 .

Pyridazines. Part 22: Highly efficient synthesis of pharmacologically useful 4-cyano-6-phenyl-5-substituted-3(2H)-pyridazinones

E. Sotelo, E. Raviña, B. Pita, 2000 .

Pyridazines XVII: An Efficient Palladium-Catalyzed Cross-Coupling Reaction for the Synthesis of 5-Substituted 6-Phenyl-(2H)-pyridazin-3-ones

Alberto Coelho, E. Raviña, I. Estevez, 1999 .

Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

M. Loza, J. Brea, E. Domínguez, 2007, Bioorganic & medicinal chemistry letters.

A simple, efficient method for regioselective synthesis of 7-aminomethyl-7,8-dihydro-6H-quinolin-5-ones, new potential CNS agents

C. Masaguer, E. Raviña, B. Pita, 2000 .

Synthesis of 5‐cyanopyrazolo[3,4‐b]pyridines in the reaction of 5‐amino‐3‐methyl‐1‐phenylpyrazole with arylidene derivatives of malonodinitrile and ethyl cyanoacetate

B. Insuasty, J. Quiroga, Mario Alvarado, 1999 .

Synthesis of 5‐Cyanopyrazolo[3,4‐b]pyridines in the Reaction of 5‐Amino‐3‐methyl‐1‐phenylpyrazole with Arylidene Derivatives of Malonodinitrile and Ethyl Cyanoacetate.

B. Insuasty, J. Quiroga, Mario Alvarado, 2000 .

Pyridazine Derivatives, VI . Synthesis and Hypotensive Activity of 3‐Hydrazinethieno(2,3‐h)Cinnoline and its Derivatives

L. Santana, C. Terán, F. Orallo, 1988, Archiv der Pharmazie.

Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.

E. Sotelo, Alberto Coelho, B. Maes, 2006, Bioorganic & medicinal chemistry letters.

In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known α1-adrenoceptor antagonist

M. Loza, F. Orallo, C. Masaguer, 2003 .

Pyridazines Part XXIII: Efficient Arylation at Position 5 of the 6-Phenyl-(2H)-pyridazin-3-one System Using a Suzuki Cross-Coupling Reaction

E. Sotelo, Alberto Coelho, E. Raviña, 2001 .

Synthesis of optically active β-benzyl-γ-butyrolactone through lipase-catalyzed kinetic resolution

Yolanda Caro, C. Masaguer, E. Raviña, 2001 .

The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs

Enrique Raviña, E. Raviña, 2011 .

Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates.

M. Sanmartín, R. Iglesias, E. Raviña, 1993, Arzneimittel-Forschung.

Synthesis of 1-substituted-6-methyluracils.

E. Sotelo, Alberto Coelho, R. Nieto, 2003, Chemical & pharmaceutical bulletin.

Pyridazines. Part 15. Synthesis of 6-Aryl-5-amino-3(2H)-pyridazinones as Potential Platelet Aggregation Inhibitors.

E. Sotelo, E. Raviña, I. Estevez, 1999 .

QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine

P. Robledo, F. Sanz, M. Loza, 2006, Neuropharmacology.

Synthesis and affinities for dopamine (D2) and 5-hydroxytryptamine (5-HT2A) receptors of 1-(benzoylpropyl)-4-(1-oxocycloalkyl-2-ethyl)-piperazines as cyclic butyrophenone derivatives.

M. L. de Ceballos, J. Calleja, C. Masaguer, 1996, Chemical & pharmaceutical bulletin.

Efficient Aromatization of 4,5-Dihydro-3(2H)-Pyridazinones Substituted at 5 Position by Using Anhydrous Copper (II) Chloride

E. Sotelo, E. Raviña, 2000 .

In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known alpha1-adrenoceptor antagonist.

M. Loza, F. Orallo, M. J. Enguix, 2003, Vascular pharmacology.

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

Karen Villalba, F. Sanz, M. Loza, 2008, Journal of medicinal chemistry.

Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT 2A and 5-HT 2C receptor behaviours.

F. Sanz, M. Loza, J. Brea, 2003, European journal of medicinal chemistry.

Pyridazine Derivatives. Part 9. Synthesis of 2H-Pyridazin-3-ones with Aroylpiperazinyl Groups.

L. Santana, C. Terán, E. Raviña, 1991 .

Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.

M. Loza, J. Brea, E. Domínguez, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and atypical antipsychotic profile of some 2-(2-piperidinoethyl)benzocycloalkanones as analogues of butyrophenone.

F. Sanz, J. Calleja, J. Rodríguez, 1994, Journal of medicinal chemistry.

Pyridazine Derivatives. Part 33. Sonogashira Approaches in the Synthesis of 5-Substituted-6-phenyl-3(2H)-pyridazinones.

E. Sotelo, Alberto Coelho, E. Raviña, 2003 .

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.

M. Loza, Alberto Coelho, J. Brea, 2005, Bioorganic & medicinal chemistry letters.

Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor.

Ferran Sanz, María Isabel Loza, Cristina Dezi, 2007, Journal of medicinal chemistry.

Pyridazines. Part 31. Synthesis and Antiplatelet Activity of 4,5-Disubstituted-6-phenyl-3(2H)-pyridazinones.

E. Sotelo, M. Yáñez, E. Raviña, 2003 .

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

Karen Villalba, F. Sanz, M. Loza, 2008, Journal of medicinal chemistry.

Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands.

F. Sanz, M. Loza, J. Brea, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.

M. L. de Ceballos, L. Santana, J. Calleja, 1991, Journal of medicinal chemistry.

5-HT2 antagonist activity of 3-aminomethyltetralones

M. Loza, J. Calleja, F. Orallo, 1991 .

Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands.

M. Loza, J. Brea, C. Masaguer, 2014, European journal of medicinal chemistry.