D. F. Skafar

发表

Understanding the human estrogen receptor-alpha using targeted mutagenesis

S. Koide, D. F. Skafar, 2006, Molecular and Cellular Endocrinology.

Interleukin-1beta-induced nitric oxide production in rat aortic endothelial cells: inhibition by estradiol in normal and high glucose cultures.

R. Muniyappa, J. Sowers, J. Ram, 1999, Life sciences.

Reproductive factors, hormone use, estrogen receptor expression and risk of non small-cell lung cancer in women.

A. Schwartz, A. Wenzlaff, M. Cote, 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Clinical review 91: Female sex hormones and cardiovascular disease in women.

J. Sowers, J. Ram, R. Xu, 1997, The Journal of clinical endocrinology and metabolism.

A-ring nitro- and amino-substituted estradiol analogs produce a negative cooperative or noncooperative [3H]estradiol-estrogen receptor binding mechanism.

J. Schwartz, D. F. Skafar, 1994, Biochemistry.

Differences in the binding mechanism of RU486 and progesterone to the progesterone receptor.

D. F. Skafar, 1991, Biochemistry.

Modulation of nuclear receptor activity by the F domain

D. F. Skafar, Shivali Patel, 2015, Molecular and Cellular Endocrinology.

Cardiovascular disease in the diabetic woman.

J. Sowers, J. Ram, S. Jacober, 1999, The Journal of clinical endocrinology and metabolism.

COMMENTARY Cardiovascular Disease in the Diabetic Woman

J. Sowers, J. Ram, S. Jacober, 1999 .

Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation.

D. Vorojeikina, T. Gasiewicz, S. Sasson, 1999, Biochemistry.

Effects of an environmental endocrine disruptor on fetal development, estrogen receptor(alpha) and epidermal growth factor receptor expression in the porcine male genital tract.

B. Duel, R. Jednak, J. Kryger, 1999, The Journal of urology.

Affinity and conformation of the estrogen receptor when bound to single-stranded vs. double-stranded nonspecific DNA.

D. F. Skafar, 1991, Journal of receptor research.

Modulation of the estrogen receptor's affinity for DNA by estradiol.

A. Notides, D. F. Skafar, 1985, The Journal of biological chemistry.

A metal‐linked gapped zipper model is proposed for theh sp90‐glucocorticoid receptor interaction

H. Mizukami, J. Schwartz, D. F. Skafar, 1993, FEBS letters.

The multifunctional estrogen receptor-alpha F domain

D. F. Skafar, Changqing Zhao, 2008, Endocrine.

Differential DNA binding by calf uterine estrogen and progesterone receptors results from differences in oligomeric states.

D. F. Skafar, 1991, Biochemistry.

Chapter 8 – THE ALLOSTERIC ESTROGEN- AND DNA-BINDING MECHANISM OF THE ESTROGEN RECEPTOR1

A. Notides, D. F. Skafar, 1987 .

Estradiol Elicits Proapoptotic and Antiproliferative Effects in Human Trophoblast Cells1

D. Armant, B. Kilburn, A. Imudia, 2015, Biology of reproduction.

Summary: Elevated estradiol in the first trimester can increase apoptosis and decrease cell proliferation in the placenta, which may contribute to intrauterine growth restriction and small for gestational age

D. Armant, B. Kilburn, A. Imudia, 2015 .

Hinge and amino-terminal sequences contribute to solution dimerization of human progesterone receptor.

D. Edwards, S. Jung, D. F. Skafar, 1997, Molecular endocrinology.

Extraembryonic heparin-binding epidermal growth factor-like growth factor deficiency compromises placentation in mice†

D. Armant, B. Kilburn, S. Das, 2018, Biology of Reproduction.

Modulation of glucocorticoid hormone receptor levels in chicken lymphoid tissue following treatment with androgens in vivo.

P. Coulson, J. Thornthwaite, D. F. Skafar, 1982, Journal of steroid biochemistry.

From ligand structure to biological activity: modified estratrienes and their estrogenic and antiestrogenic effects in MCF-7 cells

S. Brooks, D. F. Skafar, 2004, Steroids.

Ligand-mediated modulation of estrogen receptor conformation by estradiol analogs.

J. Schwartz, D. F. Skafar, 1993, Biochemistry.

Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen.

K. Reddy, S. Glaros, D. F. Skafar, 2006, Molecular endocrinology.

Female sex hormones and cardiovascular disease in women

J. Sowers, J. Ram, R. Xu, 1997 .

Formation of a powerful capping motif corresponding to start of “helix 12” in agonist-bound estrogen receptor-α contributes to increased constitutive activity of the protein

D. F. Skafar, 2007, Cell Biochemistry and Biophysics.

Targeted mutation of key residues at the start of helix 12 in the hERα ligand-binding domain identifies the role of hydrogen-bonding and hydrophobic interactions in the activity of the protein

J. Abrams, D. F. Skafar, Changqing Zhao, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Mutation of Leu-536 in Human Estrogen Receptor-α Alters the Coupling between Ligand Binding, Transcription Activation, and Receptor Conformation*

A. Koide, S. Koide, J. Abrams, 2003, Journal of Biological Chemistry.

Mutations Targeted to a Predicted Helix in the Extreme Carboxyl-terminal Region of the Human Estrogen Receptor-α Alter Its Response to Estradiol and 4-Hydroxytamoxifen*

J. Schwartz, D. F. Skafar, L. Zhong, 2002, The Journal of Biological Chemistry.

Dimerization of the RU486-bound calf uterine progesterone receptor

D. F. Skafar, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Effects of serial hormone treatments on egg white protein synthesis. Further evidence of translational regulation.

D. F. Skafar, S. Seaver, 1984, Journal of steroid biochemistry.

Agonist Activity of the 3‐Hydroxy Metabolites of Tibolone Through the Oestrogen Receptor in the Mouse N20.1 Oligodendrocyte Cell Line and Normal Human Astrocytes

M. Kleerekoper, J. Benjamins, D. F. Skafar, 2007, Journal of neuroendocrinology.

The chick oviduct in tissue culture. II. Estrogen affects ovalbumin synthesis differently than oviduct cell proliferation.

S. Baird, D. F. Skafar, S. Seaver, 1984, Experimental cell research.

Identification of regions within the F domain of the human estrogen receptor alpha that are important for modulating transactivation and protein-protein interactions.

A. Koide, S. Koide, J. Abrams, 2007, Molecular endocrinology.

Binding of [3H]progesterone to the human progesterone receptor: differences between individual and mixed isoforms.

D. Edwards, K. Christensen, D. F. Skafar, 1996, Endocrinology.

Mutations of tyrosine 537 in the human estrogen receptor-alpha selectively alter the receptor's affinity for estradiol and the kinetics of the interaction.

D. F. Skafar, L. Zhong, 2002, Biochemistry.