K. Izawa

发表

Tailor-made amino acids in the design of small-molecule blockbuster drugs.

Jianlin Han, V. Soloshonok, H. Konno, 2021, European journal of medicinal chemistry.

A practical synthesis of optically active aromatic epoxides via asymmetric transfer hydrogenation of α-chlorinated ketones with chiral rhodium–diamine catalyst

T. Ikariya, K. Izawa, Takayuki Hamada, 2004 .

Asymmetric synthesis of α-deuterated α-amino acids.

H. Moriwaki, V. Soloshonok, N. Shibata, 2017, Organic & biomolecular chemistry.

Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in the Modern Pharmaceuticals.

N. Meanwell, Haibo Mei, Jianlin Han, 2020, Chemistry.

Small‐Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment

Hong Liu, Jiang Wang, V. Soloshonok, 2016 .

Fluorine-containing pharmaceuticals approved by the FDA in 2020: Synthesis and biological activity

Wei Zhang, Haibo Mei, Jianlin Han, 2021 .

Cyclic tailor-made amino acids in the design of modern pharmaceuticals.

N. Meanwell, Jianlin Han, V. Soloshonok, 2020, European journal of medicinal chemistry.

Tailor-Made α-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)

Hong Liu, V. Soloshonok, J. L. Aceña, 2016 .

Transmission of Substituent Effects through Oxygen and Sulfur Atoms. II. 13 C Chemical Shifts of Ring-Substituted Phenyl Vinyl Ethers and Sulfides

T. Fueno, O. Kajimoto, K. Izawa, 1973 .

Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019

Wei Zhang, H. Moriwaki, Zizhen Yin, 2020, Amino Acids.

Radical deoxygenation and dehalogenation of nucleoside derivatives with hypophosphorous acid and dialkyl phosphites

S. Takamatsu, M. Naito, S. Katayama, 2001 .

Photocatalytic stereoselective N-cyclization of 2,6-diaminopimelic acid into piperidine-2,6-dicarboxylic acid by an aqueous suspension of activated cadmium(II) sulfide particles

Y. Nakato, B. Ohtani, M. Matsumura, 2001 .

Photocatalytic racemization of amino acids in aqueous polycrystalline cadmium(II) sulfide dispersions

B. Ohtani, T. Inui, S. Nishimoto, 1995 .

Production of (R)-3-Amino-3-phenylpropionic Acid and (S)-3-Amino-3-phenylpropionic Acid from (R,S)-N-Acetyl-3-amino-3-phenylpropionic Acid Using Microorganisms Having Enantiomer-Specific Amidohydrolyzing Activity

Kunihiko Watanabe, H. Kawasaki, T. Nakamatsu, 2006, Bioscience, biotechnology, and biochemistry.

Substituent Effects on the 13C and 1H Chemical Shifts of 1-Phenyl-1,3-butadiene and Phenylallene

T. Fueno, K. Izawa, T. Okuyama, 1974 .

Carbon-13 NMR Spectra of 1-Arylpropynes and 1-Arylpropenes. Transmission of the Electronic Effects of Substituents through Carbon-Carbon Triple and Double Bonds

T. Fueno, K. Izawa, T. Okuyama, 1973 .

CONVENIENT SYNTHESIS OF FLUORINATED NUCLEOSIDES WITH PERFLUOROALKANESULFONYL FLUORIDES

S. Takamatsu, S. Katayama, K. Izawa, 2002, Nucleosides, nucleotides & nucleic acids.

Synthesis of 2′,3′-Dideoxypurinenucleosides via the Palladium Catalyzed Reduction of 9-(2,5-Di-O-acetyl-3-bromo-3-deoxy-β-d-xylofuranosyl)purine Derivatives †

Yasuhiro Tanaka, K. Izawa, M. Arai, 1996 .

Synthesis of 1-(2,3-Dideoxy-β-d-glycero-pent-2-enofuranosyl)thymine (d4T; Stavudine) from 5-Methyluridine †

Y. Uchida, K. Izawa, H. Shiragami, 1996 .

Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base

Hong Liu, Jiang Wang, H. Moriwaki, 2015, Amino Acids.

An efficient synthesis of γ-amino β-ketoester by cross-claisen condensation with α-amino acid derivatives

Takayuki Suzuki, S. Katayama, K. Izawa, 2003 .

Applications of fluorine-containing amino acids for drug design.

N. Meanwell, K. Klika, Haibo Mei, 2019, European journal of medicinal chemistry.

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Wei Zhu, Hong Liu, Yu Zhou, 2016, Chemical reviews.

Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

Hong Liu, Jiang Wang, V. Soloshonok, 2014 .

Asymmetric Synthesis of N ‐Fmoc‐( S )‐7‐aza‐tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

H. Moriwaki, Jianlin Han, V. Soloshonok, 2021 .

Human–Environment Interactions – Taste

M. Kuroda, Y. Ueda, M. Kohmura, 2010 .

A concise synthesis of 3′-α-fluoro-2′,3′-dideoxyguanosine (FddG) via 3′-α-selective fluorination of 8,2′-thioanhydronucleoside

T. Maruyama, K. Izawa, T. Torii, 2006 .

Palladium-catalyzed double carbonylation of aryl halides to give .alpha.-keto amides. Mechanistic studies

Takakazu Yamamoto, F. Ozawa, A. Yamamoto, 1985 .

Synthesis of optically active alpha-aminoalkyl alpha'-halomethyl ketone: a cross-Claisen condensation approach.

Takayuki Suzuki, S. Katayama, K. Izawa, 2002, Organic letters.

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 2: Chloromethylation of N-imine-protected amino acid esters

T. Nakano, K. Izawa, M. Nakazawa, 2001 .

Enantioselective synthesis of the carbapenem ring system from (S)-proline

T. Shono, Minoru Katō, K. Izawa, 1989 .

Electrophilic additions to dienes. VI. Halogenation of phenylallene

K. Izawa, Koichi Ohashi, T. Okuyama, 1974 .

Practical synthesis of optically active styrene oxides via reductive transformation of 2-chloroacetophenones with chiral rhodium catalysts.

T. Ikariya, R. Noyori, K. Izawa, 2002, Organic letters.

New Analogs of Acyclovir Substituted at the Side Chain

J. Neyts, E. Clercq, K. Izawa, 2007, Nucleosides, nucleotides & nucleic acids.

Tandem Alkylation–Second-Order Asymmetric Transformation Protocol for the Preparation of Phenylalanine-Type Tailor-Made α-Amino Acids

H. Moriwaki, V. Soloshonok, Junya Yamamoto, 2018, ACS omega.

New approaches to the industrial synthesis of HIV protease inhibitors.

Takayuki Suzuki, S. Katayama, K. Izawa, 2004, Organic & biomolecular chemistry.

Asymmetric Synthesis of Tailor-Made Amino Acids Using Chiral Ni(II) Complexes of Schiff Bases. An Update of the Recent Literature

H. Moriwaki, Jianlin Han, V. Soloshonok, 2020, Molecules.

Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential SN2–SN2′ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(II) complex

Haibo Mei, H. Moriwaki, Jianlin Han, 2015 .

ELECTROPHILIC ADDITIONS TO DIENES PART 4, HYDROCHLORINATION OF 1-PHENYL-1,3- AND 1-PHENYL-1,2-BUTADIENES

T. Fueno, K. Izawa, T. Okuyama, 1973 .

Electrophilic additions to dienes. III. Hydrochlorination of phenylallene and its derivatives

T. Fueno, K. Izawa, T. Okuyama, 1973 .

Electrophilic additions to dienes. V. Orientation and kinetic secondary isotope effects in the addition of 2,4-dinitrobenzenesulfenyl chloride to phenylallene

T. Fueno, K. Izawa, T. Okuyama, 1973 .

Industrial syntheses of the central core molecules of HIV protease inhibitors.

K. Izawa, T. Onishi, 2006, Chemical reviews.

Next generation organofluorine containing blockbuster drugs

D. O'Hagan, H. Moriwaki, Jianlin Han, 2020 .

Chemical dynamic kinetic resolution and S/R interconversion of unprotected α-amino acids.

Hong Liu, H. Moriwaki, V. Soloshonok, 2014, Angewandte Chemie.

The Addition of 2,4-Dinitrobenzenesulfenyl Chloride to cis- and trans-1-Arylpropenes and Some Other Olefins

T. Fueno, K. Izawa, T. Okuyama, 1974 .

Synthesis of Proline and 2-Piperidinecarboxylic Acid via Cobalt-Catalyzed Isomerization–Carbonylation of N-Acyl Unsaturated Cyclic Amines

K. Izawa, Y. Amino, S. Nishi, 1991 .

Asymmetric transfer hydrogenation of α-aminoalkyl α'-chloromethyl ketones with chiral Rh complexes

T. Ikariya, K. Izawa, Takayuki Hamada, 2004 .

Synthesis of N-Acyl-α-amino acids by Cobalt Catalyzed Amido-carbonylation

K. Izawa, 1988 .

Brønsted base and acid catalysts, and additional topics

T. Hashimoto, P. Schreiner, M. Klussmann, 2012 .

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 1: Chloromethylation of N-protected 3-oxazolidin-5-ones

T. Nakano, K. Izawa, M. Nakazawa, 2001 .

Electrophilic additions to dienes. IV. Hydrochlorination of 1-phenyl-1,3- and 1-phenyl-1,2-butadienes

T. Fueno, K. Izawa, T. Okuyama, 1973 .

Synthesis of Fluorinated Nucleosides

S. Takamatsu, T. Maruyama, S. Katayama, 2006, Current protocols in nucleic acid chemistry.

SYNTHESIS AND IN VITRO ANTIVIRAL ACTIVITY EVALUATION OF 9-(2-AZIDO-2,3-DIDEOXY-β-D-THREO-PENTOFURANOSYL)ADENINE DERIVATIVES

E. De Clercq, S. Takamatsu, E De Clercq, 2001, Nucleosides, nucleotides & nucleic acids.

Photocatalytic one-step syntheses of cyclic imino acids by aqueous semiconductor suspensions

B. Ohtani, S. Nishimoto, S. Tsuru, 1990 .

Dihalomethylation of N-protected phenylalanine esters

T. Nakano, K. Izawa, T. Torii, 2001 .

Optical Resolution of Rimantadine

H. Moriwaki, Jianlin Han, V. Soloshonok, 2019, Molecules.

Synthesis of N-acyl-α-amino esters via cobalt-catalyzed carbonylation of N-acyl-α-alkoxyamines

K. Izawa, S. Nishi, Shoichi Asada, 1987 .

Synthesis of α-amino acids containing a cyclopropane ring via cobalt-catalyzed carbonylation-amidocarbonylation of cyclopropanemethanols

K. Izawa, Y. Amino, 1991 .

New pharmaceuticals approved by FDA in 2020: Small-molecule drugs derived from amino acids and related compounds.

H. Moriwaki, Jianlin Han, V. Soloshonok, 2021, Chirality.

Comparative study of different chiral ligands for dynamic kinetic resolution of amino acids.

H. Moriwaki, Jianlin Han, V. Soloshonok, 2021, Chirality.

Synthesis of 6-Arylthio Analogs of 2′,3′-Dideoxy-3′-Fluoroguanosine and Their Effect against Hepatitis B Virus Replication

E. De Clercq, J. Neyts, T. Maruyama, 2006, Nucleosides, nucleotides & nucleic acids.

INTRODUCTION OF A BENZOYL GROUP ONTO RIBOSIDE IN AQUEOUS SOLUTION : ONE-STEP SYNTHESIS OF 6-CHLOROPURINE 2', 3'-DI-O-BENZOYLRIBOSIDE

S. Takamatsu, T. Maruyama, S. Kozai, 1999 .

Stereoselective synthesis of piperidine-2,6-dicarboxylic acids by photocatalytic reaction of aqueous cadmium(II) sulfide dispersion

B. Ohtani, S. Nishimoto, S. Tsuru, 1995 .

Partial acylation of cytidine and its 2'-C-methyl analogue as a tool to functionalize the ribonucleosidic 2',3'-cis-diol system

K. Izawa, J. Boryski, P. Januszczyk, 2008 .

The Relative cis/trans Reactivity in the Hydrochlorination of 1-Arylpropenes

T. Fueno, K. Izawa, T. Okuyama, 1974 .

A synthesis of 3′-α-fluoro-2′,3′-dideoxyadenosine via a bromine rearrangement during fluorination with MOST reagent

S. Takamatsu, M. Naito, S. Katayama, 2006 .

An efficient synthesis of N-protected threo (2R,3S)-3-amino-1,2-epoxy phenylbutane

Takayuki Suzuki, K. Izawa, Y. Honda, 2005 .

A Synthesis of 3′-α-Fluoro-2′,3′-dideoxyadenosine via a Bromine Rearrangement During Fluorination with MOST Reagent.

S. Takamatsu, M. Naito, S. Katayama, 2006 .

SYNTHETIC STUDY OF 3′-α-FLUORO-2′,3′-DIDEOXYGUANOSINE

K. Izawa, T. Torii, T. Onishi, 2005 .

A Facile Synthetic Method for 3′-α-Fluoro- 2′,3′-dideoxyadenosine

S. Takamatsu, M. Naito, S. Katayama, 2003 .

An Industrial Process for Synthesizing Lodenosine (FddA)

S. Takamatsu, T. Maruyama, S. Katayama, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis of 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (FddA) via a purine 3'-deoxynucleoside.

S. Takamatsu, T. Maruyama, M. Naito, 2001, The Journal of organic chemistry.

A Novel Method for the Synthesis of ddA and F-ddA Via Regioselective 2′-O-Deacetylation of 9-(2,5-DI-O-Acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)adenine

Y. Uchida, Yasuhiro Tanaka, K. Izawa, 1992 .

Improved synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) using triethylamine trihydrofluoride

S. Takamatsu, T. Maruyama, S. Katayama, 2001 .

Practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) via a purine 3′-deoxynucleoside

S. Takamatsu, T. Maruyama, M. Naito, 2001 .

Practical syntheses of penciclovir and famciclovir from N2-acetyl-7-benzylguanine

Yumiko Suzuki, T. Kashiwagi, K. Izawa, 2006 .

A Facile Synthetic Method for 3′-α-Fluoro-2′,3′-dideoxyadenosine

S. Takamatsu, M. Naito, S. Katayama, 2004 .

Development of an Industrial Process for Synthesizing Lodenosine (FddA)

S. Takamatsu, T. Maruyama, K. Izawa, 2005 .

Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Bearing a Slectively Removable Protecting Group

S. Takamatsu, T. Maruyama, S. Kozai, 1999 .

Synthesis and Antiviral Evaluation of 2′-C-Methyl Analogues of 5-Alkynyl- and 6-Alkylfurano- and Pyrrolo[2,3-d]Pyrimidine Ribonucleosides

E. De Clercq, J. Neyts, K. Izawa, 2009, Nucleosides, nucleotides & nucleic acids.

Improved Industrial Syntheses of Penciclovir and Famciclovir Using N2-Acetyl-7-Benzylguanine and a Cyclic Side Chain Precursor

Yumiko Suzuki, K. Izawa, T. Torii, 2006, Nucleosides, nucleotides & nucleic acids.

Nucleosides, Nucleotides and Nucleic Acids

K. Izawa, Yumiko, T. Torii, 2022 .

Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) from Guanosine

S. Takamatsu, Y. Uchida, Yasuhiro Tanaka, 1995 .

Improved Synthesis of 9‐(2,3‐Dideoxy‐2‐fluoro‐β‐D‐threo‐pentofuranosyl)adenine (FddA) Using Triethylamine Trihydrofluoride.

S. Takamatsu, T. Maruyama, S. Katayama, 2001 .

Practical Synthesis of 9‐(2,3‐Dideoxy‐2‐fluoro‐β‐D‐threo‐pentofuranosyl)adenine (FddA) via a Purine 3′‐Deoxynucleoside.

S. Takamatsu, T. Maruyama, M. Naito, 2010 .

Asymmetric Transfer Hydrogenation of α-Aminoalkyl α′-Chloromethyl Ketones with Chiral Rh Complexes.

T. Ikariya, K. Izawa, Takayuki Hamada, 2005 .

Practical syntheses of antiviral nucleosides

K. Izawa, H. Shiragami, 1998 .

Synthesis of 2′,3′-Dideoxyinosine via Radical Deoxygenation

D. Jang, K. Izawa, T. Torii, 2007, Nucleosides, nucleotides & nucleic acids.

Remarkable Diastereomeric Rearrangement of an α-Acyloxy β-Ketosulfide to an α-Acyloxy Thioester: A Novel Approach to the Synthesis of Optically Active (2S,3S) β-Amino α-Hydroxy Acids

Robert M. Williams, Takayuki Suzuki, K. Izawa, 2005 .

PALLADIUM-CATALYZED DOUBLE CARBONYLATION OF ARYL HALIDES TO GIVE α-KETO AMIDES. MECHANISTIC STUDIES

Takakazu Yamamoto, F. Ozawa, A. Yamamoto, 1985 .

Chirospecific synthesis of amino acids and analogues

N. Sato, T. Ohta, S. Nozoe, 1990 .

4.16 Human–Environment Interactions – Taste

M. Kuroda, Y. Ueda, M. Kohmura, 2010 .

Synthesis of (6S,8R)‐6‐(1′‐Hydroxyethyl)carbapenem, a Thienamycin Type.

T. Ohta, S. Nozoe, K. Izawa, 1992 .

Synthesis of (6S,8R)-6-(1'-hydroxyethyl) carbapenem, a thienamycin type

N. Sato, S. Nozoe, K. Izawa, 1992 .

Chirospecific synthesis of (+)-PS-5 from L-glutamic acid

N. Sato, T. Ohta, S. Nozoe, 1988 .

Asymmetric synthesis of (S)-α-(octyl)glycine via alkylation of Ni(II) complex of chiral glycine Schiff base.

H. Moriwaki, Jianlin Han, V. Soloshonok, 2020, Chirality.

Electrophilic additions to allenes. The nature of the transition state in the protonation of phenylallenes

T. Fueno, K. Izawa, T. Okuyama, 1970 .

Asymmetric synthesis and application of α-amino acids

V. Soloshonok, K. Izawa, 2009 .

Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base

Hong Liu, Jiang Wang, H. Moriwaki, 2016, Amino Acids.

Nucleosides, Nucleotides and Nucleic Acids

Yalin Tang, Y. Ju, J. Xiang, 2008 .

Synthesis and in vitro antiviral activity evaluation of 9-(2-azido-2,3-dideoxy-beta-D-threo-pentofuranosyl)adenine derivatives.

E. Clercq, S. Takamatsu, T. Maruyama, 2001 .

Frontispiece: Tailor‐Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals

N. Meanwell, Haibo Mei, Jianlin Han, 2020 .

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Hong Liu, Yu Zhou, Jiang Wang, 2016, Chemical reviews.

Chemical dynamic kinetic resolution and S/R interconversion of unprotected α-amino acids.

Hong Liu, H. Moriwaki, V. Soloshonok, 2014, Angewandte Chemie.

Second-order asymmetric transformation and its application for the practical synthesis of α-amino acids.

H. Moriwaki, V. Soloshonok, Aki Kawashima, 2018, Organic & biomolecular chemistry.