Prasanth R. Nyalapatla

发表

A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multidrug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System Penetration Property In Vitro

Arun K. Ghosh, H. Mitsuya, D. Das, 2015, Antimicrobial Agents and Chemotherapy.

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2013, Journal of medicinal chemistry.

A New Synthesis of Gefitinib

P. Wipf, Taber S. Maskrey, M. Laporte, 2018, Synlett.

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

Arun K. Ghosh, H. Mitsuya, H. Bulut, 2019, Antimicrobial Agents and Chemotherapy.

Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.

Jinhua J. Song, B. Narayanan, C. Senanayake, 2013, The Journal of organic chemistry.

Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans.

Arun K. Ghosh, Prasanth R. Nyalapatla, 2017, Tetrahedron.

Enantioselective Total Synthesis of (+)-Amphirionin-4.

Arun K. Ghosh, Prasanth R. Nyalapatla, 2016, Organic letters.

Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes.

P. Wipf, Taber S. Maskrey, Prasanth R. Nyalapatla, 2019, Chirality.

Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants

Arun K. Ghosh, I. Weber, H. Mitsuya, 2018, ChemMedChem.

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

Arun K. Ghosh, H. Mitsuya, H. Jono, 2017, eLife.

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence

P. Wipf, M. D. Rosa, P. Opresko, 2023, bioRxiv.

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2017, Bioorganic & medicinal chemistry.

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro)

Arun K. Ghosh, A. Mesecar, Sarah E. St. John, 2015, The Journal of Biological Chemistry.

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL) IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS*

Arun K. Ghosh, A. Mesecar, M. Denison, 2015 .

Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

Arun K. Ghosh, H. Mitsuya, D. Davis, 2020, Scientific Reports.

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.

Irene T Weber, Yuan-Fang Wang, Debananda Das, 2017, Journal of medicinal chemistry.

Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

Arun K. Ghosh, I. Weber, H. Mitsuya, 2015, Organic & biomolecular chemistry.

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Arun K. Ghosh, A. Mesecar, Sarah E. St. John, 2015, Bioorganic & Medicinal Chemistry Letters.