Qinghua Hu

发表

Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome.

H. Ji, Xing Yu, Qinghua Hu, 2015, International journal of cardiology.

(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1.

Kun Hao, Qinghua Hu, Huanqiu Li, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists.

Kun Hao, Z. Meng, Cheng Jiang, 2019, European journal of medicinal chemistry.

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.

Qinghua Hu, Huanqiu Li, Chunxiao Liu, 2020, International immunopharmacology.

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors.

T. Lu, Yadong Chen, Shaohua Hou, 2021, European journal of medicinal chemistry.

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis.

Yanmin Zhang, T. Lu, Yadong Chen, 2020, European journal of medicinal chemistry.

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Yuxin Li, Qinghua Hu, H. Ji, 2021, Frontiers in Pharmacology.

Capillary leak syndrome in children with C4A-deficiency undergoing cardiac surgery with cardiopulmonary bypass: a double-blind, randomised controlled study

S. Yao, R. Ziegelstein, Shi-hai Zhang, 2005, The Lancet.

Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis

Yadong Chen, Wenjiao Jiang, Kun Hao, 2020, International journal of biological sciences.

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

Wenjiao Jiang, Kun Hao, Sheng Tian, 2022, Frontiers in Immunology.

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency Against Acute Gouty Arthritis.

Yanmin Zhang, T. Lu, Yadong Chen, 2019, Journal of medicinal chemistry.

Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.

Eun Hee Ha, Sheng Tian, E. Ha, 2020, Bioorganic & medicinal chemistry letters.

4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.

Qinghua Hu, Mengze Zhou, Wentao Liu, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.

Qinghua Hu, Jing Ji, Xiping Yang, 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The role of P2Y6R in cardiovascular diseases and recent development of P2Y6R antagonists.

H. Ji, Qian Zhang, Qinghua Hu, 2020, Drug discovery today.

Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.

H. Ji, Qinghua Hu, Zhonglin Yang, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis.

Cheng Jiang, Zhenguo Zhang, Qinghua Hu, 2022, International immunopharmacology.

Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.

Qinghua Hu, Huanqiu Li, Mingxing Miao, 2018, Bioorganic & medicinal chemistry.

P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages

Wenjiao Jiang, Qinghua Hu, Chunxiao Liu, 2020, Cell Death & Disease.

Discovery of orally active 1,4,5,6,8-pentaazaacenaphthylens as novel, selective, and potent covalent BTK inhibitors for the treatment of rheumatoid arthritis.

Yadong Chen, Yulei Jiang, Kun Zhang, 2022, European journal of medicinal chemistry.

Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.

Huan-qiu Li, G. Ao, Qinghua Hu, 2017, Bioorganic & medicinal chemistry.

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

Yihua Zhang, H. Ji, Hui Wu, 2015, Inflammation Research.

NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages

H. Ji, Y. Mou, Tong Chen, 2015, Inflammation Research.

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential.

Sheng Tian, Yifan Zhu, Qinghua Hu, 2021, European journal of medicinal chemistry.

Discovery of Novel 2‐(piperidin‐4‐yl)‐1H‐benzo[d]imidazole Derivatives as Potential Anti‐Inflammatory Agents

Huibin Zhang, Jinpei Zhou, Junhao Xing, 2015, Chemical biology & drug design.

Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy.

Sheng Tian, Duxin Li, Yifan Zhu, 2023, Journal of medicinal chemistry.

Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis.

Z. Meng, Cheng Jiang, Zhenguo Zhang, 2021, European journal of medicinal chemistry.

Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor.

Ting-ting Li, H. Ji, Qinghua Hu, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist.

Sheng Tian, X. Zhao, Yuxin Li, 2023, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Discovery of novel and potent P2Y14R antagonists via structure-based virtual screening for the treatment of acute gouty arthritis

Sheng Tian, Yingxian Liu, Qinghua Hu, 2020, Journal of advanced research.

Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease.

Qinghua Hu, Huanqiu Li, Mengze Zhou, 2023, Journal of ethnopharmacology.

Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases.

Yadong Chen, Jiapeng Zhu, Lingfeng Yin, 2023, Journal of medicinal chemistry.

Targeting P2Y14R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitis

Yifan Zhu, Qinghua Hu, Huanqiu Li, 2024, Nature communications.

Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.

Qinghua Hu, Huanqiu Li, Mengze Zhou, 2023, European heart journal.

Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics.

Yifan Zhu, Qinghua Hu, Huanqiu Li, 2024, Journal of advanced research.

Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

Yifan Zhu, Qinghua Hu, Huanqiu Li, 2024, Acta Pharmaceutica Sinica B.