Hao Chen

发表

Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid.

W. Gu, Xiao-Yan Jin, Dongdong Li, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of a novel class of β-carboline derivatives

Hao Chen, P. Gao, Meng Zhang, 2014 .

Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors

W. Gu, A-Liang Li, Wen-Yan Wang, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of 2-aryl-benzimidazole derivatives of dehydroabietic acid as novel tubulin polymerization inhibitors

Shifa Wang, Y. Geng, W. Gu, 2018, RSC advances.

Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.

S. Abrams, Hao Chen, Janet L. Taylor, 2007, Bioorganic & medicinal chemistry letters.

Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics.

A. Mutlib, L. Gan, Hao Chen, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis, in vitro Antimicrobial, and Cytotoxic Activities of New 1,3,4‐Oxadiazin‐5(6H)‐one Derivatives from Dehydroabietic Acid

Shifa Wang, W. Gu, Ting-Ting Miao, 2018 .

In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of α-Cyano-β-hydroxy-β- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton’s Tyrosine Kinase

F. Uckun, A. Vassilev, B. Waurzyniak, 2002 .

Less Cytotoxic Protoflavones as Antiviral Agents: Protoapigenone 1′-O-isopropyl ether Shows Improved Selectivity Against the Epstein–Barr Virus Lytic Cycle

J. Hohmann, Li-Kwan Chang, F. Chang, 2019, International journal of molecular sciences.

CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.

F. Uckun, E. Sudbeck, C. Mao, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives

A. Xu, H. Guan, R. Cao, 2005 .

Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.

Hao Chen, A. Mutlib, Wing Lam, 2005, Rapid communications in mass spectrometry : RCM.

Application of on-line electrochemical derivatization coupled with high-performance liquid chromatography electrospray ionization mass spectrometry for detection and quantitation of (p-chlorophenyl)aniline in biological samples.

A. Mutlib, M. Zhong, Yanhua Zhang, 2006, Analytical chemistry.

Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.

Hao Chen, A. Mutlib, L. Yu, 2010, Chemical research in toxicology.

Toxicity and Pharmacokinetics of Stampidine in Mice and Rats

F. Uckun, B. Waurzyniak, T. Venkatachalam, 2003, Arzneimittelforschung.

The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.

Karina Romero, Renee Emkey, Hao Chen, 2012, Journal of medicinal chemistry.

Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors.

W. Gu, Yue Sun, Qing-song Liu, 2020, Bioorganic chemistry.

In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.

F. Uckun, A. Vassilev, B. Waurzyniak, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors

W. Gu, A-Liang Li, Wen-Yan Wang, 2019, Journal of enzyme inhibition and medicinal chemistry.

Delineating novel metabolic pathways of DPC 963, a non-nucleoside reverse transcriptase inhibitor, in rats. Characterization of glutathione conjugates of postulated oxirene and benzoquinone imine intermediates by LC/MS and LC/NMR.

Liang-Shang Gan, Hao Chen, A. Mutlib, 2002, Chemical research in toxicology.

Biotransformation of adenine and cytokinins by the rhizobacterium Serratia proteamaculans.

Erica Anderson, S. Abrams, L. Zaharia, 2006, Phytochemistry.

Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.

A. Mutlib, C. Bigge, J. Edmunds, 2008, Chemical research in toxicology.

Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel p450-mediated metabolic reaction involving a putative oxaziridine intermediate.

A. Mutlib, L. Dethloff, J. Murray, 2006, Chemical research in toxicology.

Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.

A. Mutlib, C. Bigge, M. Jalaie, 2009, Chemical research in toxicology.

Preliminary Acute and Subchronic Toxicity Studies of GLG-V-13, a Novel Class III Antiarrhythmic Agent, in Mice

R. Lazzara, B. Scherlag, K. Berlin, 2000, Arzneimittelforschung.

Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors

W. Gu, A-Liang Li, Wen-Yan Wang, 2019, Journal of enzyme inhibition and medicinal chemistry.