L. Knutsen

发表

The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties

C. Thomsen, M. Sheardown, J. Lau, 1993 .

Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.

C. Thomsen, H. Klitgaard, L. Knutsen, 1993, European journal of pharmacology.

Unexpected neuroprotection observed with the adenosine A2A receptor agonist CGS 21680

M. Sheardown, L. Knutsen, Malcolm J. Sheardown, 1996 .

Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.

C. Earnshaw, S. Ward, Andreá Fiumana, 2007, Bioorganic & medicinal chemistry letters.

Adenosine A1 and A3 selective N‐alkoxypurines as novel cytokine modulators and neuroprotectants

C. Thomsen, M. Sheardown, S. Roberts, 1998 .

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.

P. Suzdak, F. Gronwald, C. Braestrup, 1993, Journal of medicinal chemistry.

NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.

P. Suzdak, E. B. Nielsen, K. Frederiksen, 1992, European journal of pharmacology.

(R)‐N‐[4,4‐Bis(3‐Methyl‐2‐Thienyl)but‐3‐en‐1‐yl]Nipecotic Acid Binds with High Affinity to the Brain γ‐Aminobutyric Acid Uptake Carrier

P. Suzdak, A. Mortensen, C. Braestrup, 1990, Journal of neurochemistry.

Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.

P. Ravenscroft, B. Judkins, D. Scopes, 1986, Journal of medicinal chemistry.

The Chemistry of 2′-Deoxyribo-C-Nucleosides

L. Knutsen, 1992 .

Reduction of the carboxyl-function in aromatic carboxylic acids by alkali metal–liquid ammonia solutions

R. Hayward, M. Grossel, L. Knutsen, 1978 .

Synthesis of imidazo-fused bridgehead-nitrogen 2′-deoxyribo-C-nucleosides: coupling-elimination reactions of 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonic acid

B. Judkins, D. Scopes, R. Newton, 1985 .

Preparation and Determination of the Absolute Configuration of Optically Active 9-Hydroxy-7-oxabicyclo[4.3.0]non-4-en-8-ones

D. Hibbs, M. Hursthouse, K. S. Bisht, 1995 .

Facile conversion of 4-endo-hydroxy-2-oxabicyclo[3.3.0]oct-7-en-3-one into carbocyclic 2′-deoxyribonucleoside analogues

S. Roberts, A. Dhanda, D. Varley, 1999 .

A novel elimination reaction of 3,4,6-tri-O-benzoyl-2,5-anhydro-D-allonic acid: ribosyl → 2′-deoxyribosyl conversion

B. Judkins, D. Scopes, R. Newton, 1982 .

P1 and P2 Purine and Pyrimidine Receptor Ligands

K. Jacobson, L. Knutsen, 2001 .

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.

C. Thomsen, S. Roberts, L. Knutsen, 1998, Bioorganic & medicinal chemistry letters.

Characterization of [3H]‐N‐[R‐(2‐ Benzothiazolyl)thio‐2‐propyl]‐2‐chloroadenosine ([3H]‐NNC 21‐0136) binding to rat brain: Profile of a novel selective agonist for adenosine A1 receptors

C. Foged, C. Thomsen, L. Knutsen, 1997 .

Coupling-elimination reactions of 2,5-anhydro-3,4,6-tri-O-benzoyl-d-allonic acid: synthesis of 2′-deoxyribo-C-nucleosides

D. Scopes, R. Newton, L. Knutsen, 1982 .

Stereoselective conversion of 2′,3′-dideoxydidehydro carbocyclic nucleosides into 2′-deoxy carbocyclic nucleosides

S. Roberts, A. Dhanda, D. Varley, 1998 .

14C‐labelling of a novel antiischaemic adenosine A1 agonist at purine C‐8

C. Foged, L. Knutsen, J. S. Valsborg, 1996 .

Anticonvulsant Actions of Novel and Reference Adenosine Agonists

M. Judge, J. Weis, C. Thomsen, 1995 .

Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.

M. Williams, E. Bacon, C. Prouty, 2011, Journal of medicinal chemistry.

Local and adjunct anesthesia

T. A. Bowdle, L. Knutsen, M. Williams, 2007 .

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.

P. Suzdak, C. Braestrup, U. Sonnewald, 1991, European journal of pharmacology.

Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.

P. Suzdak, Michael D B Swedberg, R. Henry, 1999, Journal of medicinal chemistry.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.

A. Lawrence, R. Gillespie, S. Ward, 2008, Bioorganic & medicinal chemistry letters.

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.

M. Judge, A. Hansen, J. Weis, 1999, Journal of medicinal chemistry.

Synthesis of [8-14C]-2,6-dichloro-9H-purine, a radiolabelled precursor for 14C-nucleosides

C. Foged, I. Lundt, L. Knutsen, 1995 .

6.11 – Epilepsy

M. Williams, L. Knutsen, 2007 .

Drug discovery management, small is still beautiful: Why a number of companies get it wrong.

L. Knutsen, 2011, Drug discovery today.

Emerging opportunities for antipsychotic drug discovery in the postgenomic era.

Michael Williams, M. Marino, L. Knutsen, 2008, Journal of medicinal chemistry.

Erratum: Sheardown MJ, Knutsen LJS (1996): Unexpected neuroprotection observed with the adenosine A2A receptor agonist CGS 21680. Drug Dev Res 39:108‐114.

M. Sheardown, L. Knutsen, 1997 .

Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.

P. Suzdak, Michael D B Swedberg, J. Sorensen, 1999, Journal of medicinal chemistry.

In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.

P. Suzdak, Michael D B Swedberg, C. Braestrup, 1992, Life Science.

Synthesis of imidazo-fused bridgehead-nitrogen C-nucleosides via dehydrative coupling reactions of 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonic acid

B. Judkins, D. Scopes, R. Newton, 1984 .

KW-6002 (Kyowa Hakko Kogyo).

S. Weiss, L. Knutsen, 2001, Current opinion in investigational drugs.

Synthesis and Antiviral Activity of 5-Halovinyl-6-Aza-2′-Deoxyuridines

P. Ravenscroft, D. Scopes, R. Newton, 1985 .

The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.

L. Knutsen, J. Mogensen, A. Bowler, 1998, Bioorganic & medicinal chemistry letters.

Drug discovery management, small is still beautiful: Why a number of companies get it wrong.

L. Knutsen, 2011, Drug discovery today.