G. Cornelius

发表

Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.

S. Spergel, G. Trainor, L. Schweizer, 2015, ACS medicinal chemistry letters.

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

Honglu Zhang, S. Ball, H. Lim, 2001, Drug metabolism and disposition: the biological fate of chemicals.

DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors.

T. Olah, L. Cornelius, J. Santella, 2010, Bioanalysis.

Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.

Michael G. Yang, K. McIntyre, D. Shen, 2019, Journal of medicinal chemistry.

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Shana L. Posy, J. Fargnoli, R. Talbott, 2015, ACS medicinal chemistry letters.

Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization.

Michael G. Yang, D. Shuster, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.

R. Talbott, R. Borzilleri, T. Olah, 2016, Bioanalysis.

Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).

Michael A. Galella, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.

Michael G. Yang, K. McIntyre, D. Shen, 2016, Journal of medicinal chemistry.

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, ACS medicinal chemistry letters.

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

K. McIntyre, D. Shuster, D. Shen, 2016, Journal of medicinal chemistry.

Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.

S. Spergel, R. Moquin, K. McIntyre, 2016, Journal of medicinal chemistry.

Identification of potent tricyclic prodrug S1P1 receptor modulators.

K. McIntyre, D. Shen, A. Mathur, 2017, MedChemComm.

Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).

S. Spergel, K. McIntyre, D. Shuster, 2016, Bioorganic & medicinal chemistry letters.

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.

K. McIntyre, D. Shen, J. Barrish, 2016, ACS medicinal chemistry letters.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.

Michael G. Yang, K. McIntyre, D. Shen, 2020, ACS medicinal chemistry letters.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, Journal of medicinal chemistry.

Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.

A. D. Rodrigues, W. Humphreys, P. Marathe, 2011, Chemical research in toxicology.

Utility of gastric-retained alginate gels to modulate pharmacokinetic profiles in rats.

Kimberly A. Foster, M. Hageman, Huadong Sun, 2013, Journal of pharmaceutical sciences.