Yuanwei Chen

发表

Discovery and biological evaluation of darolutamide derivatives as inhibitors and down-regulators of wild-type AR and the mutants.

Xinghai Li, Mingxing Hu, J. Yu, 2019, European journal of medicinal chemistry.

Synthesis and evaluation of novel thiazole‐based derivatives as selective inhibitors of DNA‐binding domain of the androgen receptor

J. Yu, Lifeng Zhao, Ruixue Xu, 2018, Chemical biology & drug design.

Development of selective mono or dual PROTAC degrader probe of CDK isoforms.

Jijun Cheng, Yongmei Xie, Lifeng Zhao, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties.

Lifeng Zhao, Lingling Peng, Ruixue Xu, 2015, Journal of labelled compounds & radiopharmaceuticals.

Conformationally Constrained Spiro C‐Arylglucosides as Potent and Selective Renal Sodium‐Dependent Glucose Co‐transporter 2 (SGLT2) Inhibitors

B. Seed, A. Welihinda, Jiajia Dong, 2010, ChemMedChem.

EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.

J. Y. Roberge, B. Seed, Yongxiang Wang, 2011, Pharmacological research.

ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

B. Seed, Kun-Jian Peng, A. Welihinda, 2010, Bioorganic & medicinal chemistry.

Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of PARP1 for Treating Cancers.

Lifeng Zhao, Yong Chen, Jie Yang, 2020, Journal of medicinal chemistry.

Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents

Zhangxiang Liu, Yuanwei Chen, C. Shi, 2007 .

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

B. Seed, Kun-Jian Peng, A. Welihinda, 2009, Bioorganic & medicinal chemistry letters.

Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide

Xiaoyan Chen, D. Zhong, Xiao-jian Dai, 2016, Drug design, development and therapy.

A New Total Synthesis ofD-threo-L-talo-Octose

P. Vogel, Yuanwei Chen, D. Neff, 1991 .

A convenient method for the Ru(0)-catalyzed regioselective deuteration of N-alkyl-substituted anilines

Lifeng Zhao, Ruixue Xu, Yuanwei Chen, 2014 .

Silver-Assisted, Iridium-Catalyzed Allylation of Bis[(pinacolato)boryl]methane Allows the Synthesis of Enantioenriched Homoallylic Organoboronic Esters

D. Niu, Ren-Zhe Li, Yuanwei Chen, 2016 .

Novel thiohydantoin analogues bearing the 1-hydroxyl-2,2,2-trifluoro-1-ethyl moiety as androgen receptor inhibitors for the potential treatment of castration resistant prostate cancer

Lifeng Zhao, Fan Lei, J. Yu, 2017 .

Effect of N-methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide.

Lingling Peng, Yuanwei Chen, Xuehai Pang, 2017, Journal of labelled compounds & radiopharmaceuticals.

A simple method for α-position deuterated carbonyl compounds with pyrrolidine as catalyst.

Yongmei Xie, Haoxi Huang, Yuanwei Chen, 2014, Journal of labelled compounds & radiopharmaceuticals.

Total Asymmetric Syntheses of 1,5-Dideoxy-1,5-Iminooctitols and 1,2,6,7,8-Pentahydroxyindolizidines

P. Vogel, Yuanwei Chen, 1994 .

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.

J. Y. Roberge, Wei-Chang Fu, Kun-Jian Peng, 2014, Journal of medicinal chemistry.

Asymmetric carbonyl addition with the homochiral ketimine derived from (+) or (−)-pinanone and benzylamine

Yaozhong Jiang, Jing Wang, A. Mi, 1990 .

A Simple and Cost‐Effective Method for the Regioselective Deuteration of Phenols

Yongmei Xie, Lifeng Zhao, Ruixue Xu, 2015 .

Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Jonathan Greer, V. Stoll, J. Greer, 2003, Biochemistry.

Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors.

Lifeng Zhao, Guoyi Yan, Yufang Deng, 2017, Journal of medicinal chemistry.

Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer.

J. Yu, Xinghai Li, Guoyi Yan, 2019, European journal of medicinal chemistry.

Phase I clinical trial of HC‐1119: A deuterated form of enzalutamide

Jiyan Liu, Xinghai Li, F. Bi, 2021, International journal of cancer.

Metabolically Stable Diphenylamine Derivatives Suppress Androgen Receptor and BET Protein in Prostate Cancer.

Xinghai Li, J. Yu, Guoyi Yan, 2020, Biochemical pharmacology.

O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

B. Seed, A. Welihinda, Yan Feng, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of pyridine derivatives that selectively inhibits mutant isocitrate dehydrogenase 2

Yinglan Zhao, Lifeng Zhao, Mingxing Hu, 2018, Chemical biology & drug design.

Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles.

Yuanwei Chen, Ying-wei Wang, Xuehai Pang, 2017, Bioorganic & medicinal chemistry letters.

C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

J. Y. Roberge, B. Seed, Huawei Cheng, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of deuterated Tivozanib for improving pharmacokinetic properties.

Lingling Peng, Shiwei Guo, Yuanwei Chen, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of urea acetates as potential PPARα/γ dual agonists

Changcheng Zhao, Yuanwei Chen, C. Shi, 2008 .

HPLC Determination of Enantiomeric Purity of Letermovir Based on CHIRALPAK AD.

Tinghong Ye, Xiaolin Zhang, Mengya Liao, 2016, Journal of chromatographic science.

Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties.

Lifeng Zhao, Yufang Deng, Yuanwei Chen, 2018, Bioorganic & medicinal chemistry letters.

Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

B. Seed, Kun-Jian Peng, A. Welihinda, 2009, Bioorganic & medicinal chemistry letters.