Toshihide Shibazaki

Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.

Tomonaga Ozawa, Susumu Kobayashi, N. Kamada, 2012, Bioorganic & medicinal chemistry.

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure.

M. Hongo, Miwa Horiuchi-Hirose, H. Shimojo, 2012, American journal of physiology. Heart and circulatory physiology.

Prevention ou traitement de maladies dues a l'hyperglycemie

N. Fushimi, Toshihide Shibazaki, Masaki Tomae, 2003 .

Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).

Susumu Kobayashi, Y. Yamauchi, N. Kamada, 2013, Bioorganic & medicinal chemistry.

The proximal C-terminus of α(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.

B. Flucher, Miwa Horiuchi-Hirose, M. Yamada, 2012, The Biochemical journal.

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.

H. Ueda, T. Moriizumi, M. Hongo, 2011, American journal of physiology. Heart and circulatory physiology.

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models

F. Itoh, N. Fushimi, Toshihide Shibazaki, 2012, Journal of Pharmacology and Experimental Therapeutics.

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca²⁺ channels revealed by Timothy syndrome mutation.

T. Aoyama, Miwa Horiuchi-Hirose, M. Yamada, 2012, European journal of pharmacology.

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.

H. Ueda, T. Moriizumi, M. Hongo, 2011, American journal of physiology. Heart and circulatory physiology.