C. Spilling

发表

Inhibition of Ag 85 C by Cyclipostins and Cyclophostin 1 Cyclipostins and Cyclophostin analogs inhibit the antigen 85 C from Mycobacterium tuberculosis both in vitro and in vivo

L. Kremer, L. Camoin, M. Blaise, 2018 .

Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo

L. Kremer, L. Camoin, M. Blaise, 2018, The Journal of Biological Chemistry.

Synthesis of the C(18)-C(34) fragment of amphidinolide C and the C(18)-C(29) fragment of amphidinolide F.

Sudeshna Roy, C. Spilling, 2010, Organic letters.

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis

L. Kremer, R. Puppo, J. Cavalier, 2017, Scientific Reports.

Synthesis of Phosphonomethyl Tetrahydrofurans via the Mori-Tamaru Reaction of Phosphonodienes.

N. Rath, R. Paudel, C. Spilling, 2020, Organic letters.

Intermolecular charge transfer in organic donor-acceptor systems for optical storage applications

Zhi Xu, Ying Dong, Vasudevan Lakshminarayanan, 1998, Other Conferences.

Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B.

P. Groundwater, S. Bhakta, M. Gray, 2012, Journal of natural products.

Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.

F. Carrière, J. Cavalier, V. Delorme, 2012, Journal of medicinal chemistry.

Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases.

L. Kremer, J. Herrmann, J. Cavalier, 2017, International journal of antimicrobial agents.

Synthesis and Biological Characterization of Fluorescent Cyclipostins and Cyclophostin Analogues: New Insights for the Diagnosis of Mycobacterial-Related Diseases.

J. Cavalier, S. Canaan, Benjamin P. Martin, 2022, ACS infectious diseases.

The preparation of acyl phosphonates by the heterogeneous oxidation of 1-hydroxy phosphonates

Y. Liao, C. Spilling, H. Shabany, 1998 .

Trapping Hemiacetals with Phosphono Substituted Palladium π-Allyl Complexes for the Synthesis of Substituted Cyclic Ethers.

Surendra Dawadi, C. Spilling, N. Sutivisedsak, 2015, Tetrahedron letters.

Transfer hydrogenation: A stereospecific method for the conversion of nitro alkanes into amines

A. Barrett, C. Spilling, 1988 .

Synthesis of cyclopentenones via intramolecular HWE and the palladium-catalyzed reactions of allylic hydroxy phosphonate derivatives.

C. Spilling, Bingli Yan, 2008, The Journal of organic chemistry.

Stereospecific Pd(O)-catalyzed malonate additions to allylic hydroxy phosphonate derivatives: a formal synthesis of (-)-enterolactone.

C. Spilling, Bingli Yan, 2004, The Journal of organic chemistry.

Reactions of Chiral Phosphorous Acid Diamides: The Asymmetric Synthesis of Chiral .alpha.-Hydroxy Phosphonamides, Phosphonates, and Phosphonic Acids

K. Koeller, C. Spilling, V. J. Blazis, 1995 .

The synthesis, structure and properties of diazaphospholes: Reagents and ligands for asymmetric synthesis

K. Koeller, N. Rath, C. Spilling, 1998 .

The synthesis of azadirachtin: a potent insect antifeedant.

D. Jennens, M. Göbel, A. Wood, 2008, Chemistry.

Chemistry of Insect Antifeedants from Azadirachta indica (Part 22): Functionalisation of the Decalin Fragment of Azadirachtin via a Claisen Rearrangement Reaction

S. Ley, C. Spilling, C. Gutteridge, 1999 .

Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: synthesis of verongamine and purealidin N.

J. J. Harburn, C. Spilling, T. Boehlow, 2001, The Journal of organic chemistry.

The regio- and stereo- selective epoxidation of alkenes with methyl trioxorhenium and urea-hydrogen peroxide adduct

C. Spilling, T. Boehlow, 1996 .

Stereospecific Pd(0)-catalyzed arylation of an allylic hydroxy phosphonate derivative: formal synthesis of (S)-(+)-ar-turmerone.

C. Spilling, B. J. Rowe, 2003, The Journal of organic chemistry.

The enantioselective addition of dialkylphosphites to aldehydes: Catalysis by a lanthanum binaphthoxide complex

N. Rath, C. Spilling, 1994 .

Synthesis of non-racemic α-hydroxyphosphonates via asymmetric phospho-aldol reaction.

R. Malla, C. Spilling, 2016, Topics in current chemistry.

New homochiral cyclic diol ligands for titanium alkoxide catalyzed phosphonylation of aldehydes

C. Spilling, Michael D. Groaning, B. J. Rowe, 1998 .

Synthesis of Phostones via the Palladium-Catalyzed Ring Opening of Epoxy vinyl phosphonates.

N. Rath, C. Spilling, G. Gnawali, 2019, The Journal of organic chemistry.

Enantioseparation of α-Hydroxyallylphosphonates and Phosphonoallylic Carbonate Derivatives on Chiral Stationary Phases Using Sequential UV, Polarimetric, and Refractive Index Detection.

B. Hamper, C. Spilling, M. Mannino, 2016, Chirality.

Relay cross metathesis reactions of vinylphosphonates

R. Malla, C. Spilling, Jeremy N Ridenour, 2014, Beilstein journal of organic chemistry.

Enantioselective inhibition of microbial lipolytic enzymes by nonracemic monocyclic enolphosphonate analogues of cyclophostin.

F. Carrière, J. Cavalier, S. Canaan, 2013, Journal of medicinal chemistry.

Allylic hydroxy phosphonates: versatile chiral building blocks

N. Rath, C. Spilling, A. He, 2005 .

Stereospecific Pd(O)‐Catalyzed Malonate Additions to Allylic Hydroxy Phosphonate Derivatives: A Formal Synthesis of (‐)‐Enterolactone.

C. Spilling, Bingli Yan, 2004 .

The synthesis of 1-hydroxy phosphonates of high enantiomeric excess using sequential asymmetric reactions: titanium alkoxide-catalyzed PC bond formation and kinetic resolution

C. Spilling, B. J. Rowe, 2001 .

Formation of Cyclic Acetals from Allylic Hydroxy Phosphonates via Intramolecular Oxymercuration

C. Spilling, A. Thanavaro, 2002 .

Determination of the enantiomeric purity and absolute configuration of a-hydroxy phosphonates

N. Rath, C. Spilling, James K. Kozlowski, 1995 .

Substituent effects in the reaction of allyl trichloroacetimidates with N-halosuccinimides: Cyclization vs aza-Claisen rearrangement

C. Spilling, H. Shabany, 1998 .

Asymmetric synthesis of α-hydroxy- phosphonamides, phosphonates and phosphonic acids

K. Koeller, C. Spilling, V. J. Blazis, 1994 .

Reactions of Chiral Phosphorus Acid Diamides: The Asymmetric Synthesis of Chiral α‐Hydroxy Phosphonamides, Phosphonates, and Phosphonic Acids.

K. Koeller, C. Spilling, V. J. Blazis, 1995 .

Reactions of chiral phosphorous acid diamides

K. Koeller, C. Spilling, V. J. Blazis, 1993 .

Synthesis of Cyclopentenones via Intramolecular HWE and the Palladium‐Catalyzed Reactions of Allylic Hydroxy Phosphonate Derivatives.

C. Spilling, Bingli Yan, 2008 .

A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis.

Chung F. Wong, Zhon-Yin Zhang, Li Wu, 2014, Bioorganic & medicinal chemistry.

The preparation and reactions of chiral phosphorous acid diamides

K. Koeller, C. Spilling, 1991 .

The Synthesis, Structure and Properties of Diazaphospholes: Reagents and Ligands for Asymmetric Synthesis.

K. Koeller, N. Rath, C. Spilling, 1998 .

Preparation and structure of new homochiral diazaphosphole ligands and their platinum(II) chloride complexes

G. K. Anderson, N. Rath, C. Spilling, 1998 .

REACTIONS OF CHIRAL PHOSPHORUS ACID DIAMIDES: LEWIS ACID CATALYZED ADDITION TO IMINES AND OXIDATION WITH SnCl4

K. Koeller, N. Rath, C. Spilling, 1995 .

(Benzyloxy)nitromethane: a new reagent in bicyclic .beta.-lactam synthesis

A. Barrett, Sven J. Taylor, C. Spilling, 1989 .

Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.

C. M. Dupureur, Supratik Dutta, R. Malla, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a phosphonate analog of the natural acetyl cholinesterase inhibitor cyclophostin.

C. M. Dupureur, Supratik Dutta, N. Rath, 2008, The Journal of organic chemistry.

Stereoselective synthesis of cyclic ethers via the palladium-catalyzed intramolecular addition of alcohols to phosphono allylic carbonates.

C. Spilling, N. Sutivisedsak, A. He, 2009, Organic letters.

Total synthesis of rapamycin.

Matthew L. Maddess, S. Marsden, S. Ley, 2009, Chemistry.

Total synthesis of rapamycin.

Matthew L. Maddess, S. Ley, P. Brennan, 2007, Angewandte Chemie.

Rat hormone sensitive lipase inhibition by cyclipostins and their analogs.

C. M. Dupureur, Supratik Dutta, Benjamin P. Martin, 2015, Bioorganic & medicinal chemistry.

Approaches to avermectin assembly: a concise stereospecific synthesis of the hexahydrobenzofuran entity.

A. Barrett, J. Flygare, M. Sabat, 1990 .

Dichloroisopropoxytitanium nitronates as reagents for stereoselective Henry reactions

A. Barrett, C. Spilling, C. Robyr, 1989 .

New homochiral amino-phosphine ligands: application in asymmetric palladium catalyzed allylic alkylation

N. Rath, C. Spilling, I. C. Vasconcelos, 1998 .

Chemistry of glucal halohydrins(II): An unusual protecting group effect in the competitive formation of formyl furanosides and methyl glycosides

N. Rath, Cecilia H Marzabadi, C. Spilling, 1997 .

The first total synthesis of (±)-cyclophostin and (±)-cyclipostin P: inhibitors of the serine hydrolases acetyl cholinesterase and hormone sensitive lipase.

C. M. Dupureur, Supratik Dutta, R. Malla, 2011, Organic letters.

The chemistry of glucal halohydrins: The effect of the halide on epoxide formation

Cecilia H Marzabadi, C. Spilling, L. M. Tyler, 1994 .

Palladium Catalyzed Additions to Allylic Hydroxy Phosphonates: Applications in the Enantioselective Synthesis of Enterolactone and Turmerone

C. Spilling, B. J. Rowe, Jeffrey Scholten, 2002 .

New Catalysts for the Asymmetric Hydrophosphonylation of Aldehydes1

C. Spilling, M. Groning, B. J. Rowe, 1999 .

Stereoselective Reactions of Allylic Hydroxy Phosphonates

C. Spilling, H. Shabany, M. D. L. Cruz, 1999 .

Synthesis of nonracemic allylic hydroxy phosphonates via alkene cross metathesis.

N. Rath, C. Spilling, A. He, 2004, The Journal of organic chemistry.

Asymmetric synthesis of 2-alkyl-3-phosphonopropanoic acids via P-C bond formation and hydrogenation.

N. Rath, C. Spilling, P. A. Badkar, 2007, Organic letters.

Stereoselective syntheses of S-phenyl tetrahydrofuran-2-thiocarboxylate and tetrahydropyran-2-thiocarboxylate derivatives using (phenylthio)nitromethane

A. Barrett, J. Flygare, C. Spilling, 1989 .

Stereocontrolled total synthesis of the penicillanate ester (2S,5R)-benzyl 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate

S. Sakdarat, A. Barrett, Sven J. Taylor, 1989 .

Approaches to the Synthesis of Some Tyrosine‐Derived Marine Sponge Metabolites: Synthesis of Verongamine (IV) and Purealidin N (X).

J. J. Harburn, C. Spilling, T. Boehlow, 2010 .

An Efficient Biomimetic Synthesis of Some Marine Sponge Tyrosine Metabolites

C. Spilling, T. Boehlow, 1995 .

Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin.

C. M. Dupureur, Benjamin P. Martin, C. Spilling, 2015, Bioorganic & medicinal chemistry.

Stereoselective glucal epoxide formation

Cecilia H Marzabadi, C. Spilling, C. Marzabadi, 1993 .

Leaving Group Effects in a Series of Electrosprayed CcHhN1 Anthracene Derivatives

S. Guan, Maha T. Abutokaikah, Benjamin J. Bythell, 2019, Journal of The American Society for Mass Spectrometry.

Stereoselective Glucal Epoxide Formation.

Cecilia H Marzabadi, C. Spilling, 1993 .

A formal synthesis of the C1-C9 fragment of amphidinolide C employing the Tamaru reaction.

N. Rath, C. Spilling, Mahesh P Paudyal, 2010, Organic letters.

Effects of proline analog binding on the spectroscopic and redox properties of PutA.

D. Becker, Weidong Zhu, C. Spilling, 2002, Archives of biochemistry and biophysics.

Release of iron from transferrin by phosphonocarboxylate and diphosphonate chelating agents.

C. Spilling, M. Xin, W. Harris, 2004, Journal of inorganic biochemistry.

A Filtration System That Greatly Reduces Aluminum in Calcium Gluconate Injection, USP Used to Prepare Parenteral Nutrition Solutions.

V. P. Abramov, R. Yokel, R. Kuhn, 2014, The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG.

Cyclipostins and Cyclophostin analogs are multi-target inhibitors that impair growth of Mycobacterium abscessus.

L. Kremer, S. Audebert, L. Camoin, 2019, ACS infectious diseases.

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis

L. Kremer, R. Puppo, J. Cavalier, 2017, Scientific Reports.

Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis

S. Audebert, L. Camoin, P. Fourquet, 2022, The FEBS journal.

Lipolytic enzymes inhibitors: A new way for antibacterial drugs discovery.

T. Durand, L. Camoin, J. Cavalier, 2020, European journal of medicinal chemistry.

The Chemistry and Biology of Cyclophostin, the Cyclipostins and Related Compounds

C. Spilling, 2019, Molecules.

Efficient synthesis of tyrosine-derived marine sponge metabolites via acylation of amines with a coumarin.

J. J. Harburn, N. Rath, J Jonathan Harburn, 2005, The Journal of organic chemistry.

Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.

C. Welch, M. G. Campbell, E. Regalado, 2014, Organic & biomolecular chemistry.

Concise synthesis of 1,3-di-O-substituted tetrahydropyran derivatives as conformationally stable pyranose mimetics

A. Demchenko, L. K. Mydock, C. Spilling, 2011 .

Leaving Group Effects in a Series of Electrosprayed CcHhN1 Anthracene Derivatives

S. Guan, Maha T. Abutokaikah, Benjamin J. Bythell, 2019, Journal of The American Society for Mass Spectrometry.

An expeditious total synthesis of both diastereoisomeric lipid dihydroxytetrahydrofurans from Notheia anomala.

Sudeshna Roy, C. Spilling, 2012, Organic letters.