L. Marcin

发表

Chapter 3 Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease

R. Olson, L. Marcin, 2007 .

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

J. Macor, A. Mathur, M. Ahlijanian, 2019, ACS medicinal chemistry letters.

Mitsunobu reactions of n-alkyl and n-acyl sulfonamides-an efficient route to protected amines

P. Scola, J. Henry, S. Weinreb, 1989 .

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid β Reduction by β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

J. Macor, J. Marcinkeviciene, M. Ford, 2008, Journal of Pharmacology and Experimental Therapeutics.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

J. Macor, A. Mathur, B. Srikumar, 2018, ACS medicinal chemistry letters.

Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.

M. Seager, J. Macor, A. Hendricson, 2017, Bioorganic & medicinal chemistry.

Total Synthesis of (±)-Batrachotoxinin A

M. Kurosu, Y. Kishi, L. Marcin, 1998 .

Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.

J. Macor, H. Lewis, Chiehying Y Chang, 2016, Journal of medicinal chemistry.

2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.

J. Macor, D. Barten, C. Polson, 2012, Bioorganic & medicinal chemistry letters.

(R)‐(−)‐2,2‐Diphenylcyclopentanol

S. Denmark, A. Thorarensen, M. Schnute, 2003 .

Nitroalkene Inter [4 + 2]/Intra [3 + 2] Tandem Cycloadditions. 7. Application of (R)-(-)-2,2-Diphenylcyclopentanol as the Chiral Auxiliary

S. Denmark, A. Thorarensen, M. Schnute, 1995 .

A General Method for the Preparation of 2,2-Disubstituted 1-Nitroalkenes

S. Denmark, L. Marcin, 1993 .

A USEFUL MODIFICATION OF THE GARST-SPENCER FURAN ANNULATION : AN IMPROVED SYNTHESIS OF 3,4-SUBSTITUTED FURANS

M. Kurosu, Y. Kishi, L. Marcin, 1998 .

Asymmetric Nitroalkene [4 + 2] Cycloadditions: Enantioselective Synthesis of 3-Substituted and 3,4-Disubstituted Pyrrolidines

S. Denmark, L. Marcin, 1995 .

Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.

B. Beno, M. Cunningham, T. Molski, 2005, Journal of medicinal chemistry.

ASYMMETRIC CONSTRUCTION OF A QUATERNARY CARBON CENTER BY TANDEM 4 + 2/3 + 2 CYCLOADDITION OF A NITROALKENE. THE TOTAL SYNTHESIS OF (-)-MESEMBRINE

S. Denmark, L. Marcin, 1997 .

Nitroalkene Inter (4+2)/Intra (3+2) Tandem Cycloadditions. Part 7. Application of (R)‐(‐)‐2,2‐Diphenylcyclopentanol as the Chiral Auxiliary.

S. Denmark, A. Thorarensen, M. Schnute, 1995 .

A General Method for the Preparation of 2,2‐Disubstituted 1‐ Nitroalkenes.

S. Denmark, L. Marcin, 1993 .

trans‐2,5‐Dimethylpyrrolidine

T. Livinghouse, JaeMo Yang, L. Marcin, 2007 .

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.

T. Molski, R. Mattson, N. Lodge, 2010, Bioorganic & medicinal chemistry letters.

Catalytic asymmetric diazoacetate cyclopropanation of 1-tosyl-3-vinylindoles. A route to conformationally restricted homotryptamines.

R. Mattson, L. Marcin, D. Denhart, 2005, Organic Letters.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

J. Macor, M. Ahlijanian, Joseph L. Cantone, 2014, International journal of Alzheimer's disease.

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.

J. Macor, C. Albright, R. Olson, 2010, ACS medicinal chemistry letters.

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

J. Macor, J. Marcinkeviciene, P. Morin, 2011, Bioorganic & medicinal chemistry letters.

Nitroalkene [4+2] cycloaddition as a general and stereoselective route to the synthesis of 3,3- and 3,4-disubstituted pyrrolidines

S. Denmark, L. Marcin, 1993 .

Amino-caprolactam derivatives as γ-secretase inhibitors

J. Toyn, D. Barten, C. Polson, 2007 .

Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Synthesis of β‐Disubstituted β‐Amino Isoxazolyl Ketones by Addition of Ketimines with Isoxazolyl Methyl Ketone Enolates.

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder

J. Macor, A. Mathur, B. Srikumar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Synthesis and hSERT activity of homotryptamine analogs. Part 6: [3+2] dipolar cycloaddition of 3-vinylindoles.

T. Molski, R. Mattson, N. Lodge, 2010, Bioorganic & medicinal chemistry letters.