A. Zhang

发表

Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP).

J. Luz, M. Hickey, S. D. Kahl, 2020, Biochimica et biophysica acta. General subjects.

Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.

S. Atwell, J. Ho, J. Monn, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 5-aminimidazole-4-carboxamide riboside derivatives as anti-fatigue agents

Xiang Li, X. Li, A. Zhang, 2022, Arabian Journal of Chemistry.

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

J. Benach, H. Broughton, C. Rauch, 2022, npj Breast Cancer.

Crystal structure of 4-(3,4-bis(2,5-dimethylthiophen-3-yl)- cyclopent-3-en-1-yl)benzaldehyde, C24H24OS2

Y. Son, Xiaochuan Li, A. Zhang, 2010 .

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.

J. Luz, Y. Qian, T. Gheyi, 2013, Journal of medicinal chemistry.

Metabotropic Glutamate Receptor

J. F. Soriano, P. Ornstein, S. Atwell, 2016 .

Crystal structure of the human PRMT5:MEP50 complex

Aiping Zhang, Spencer Emtage, Bomie Han, 2012, Proceedings of the National Academy of Sciences.

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

J. Bonanno, T. Gheyi, L. Rodgers, 2013, PloS one.

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery

M. J. Chalmers, S. Wasserman, D. Manglicmot, 2018, PloS one.

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

J. F. Soriano, P. Ornstein, S. Atwell, 2016, Journal of medicinal chemistry.

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.

J. Luz, M. J. Fisher, Matthew R. Lee, 2015, Journal of medicinal chemistry.

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

J. Benach, H. Broughton, C. Rauch, 2022, npj Breast Cancer.