J. Milligan

发表

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

H. Rosen, C. L. Lynch, J. Hale, 2002, Science.

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.

M. Candelore, S. Mandala, J. Bergstrom, 2002, Biochemical and biophysical research communications.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

J. Demartino, E. Sherer, P. Váchal, 2012, Journal of medicinal chemistry.

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

R. Proia, M. Forrest, C. Meyers, 2004, Journal of Pharmacology and Experimental Therapeutics.

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies

K. Bartizal, C. Douglas, J. Marrinan, 1996, Infection and immunity.

The isolation and structure elucidation of zaragozic acid C, a novel potent squalene synthase inhibitor.

K. Wilson, F. Peláez, G. Bills, 1992 .

Carbazate as a glycine bioisostere in restricticin.

A. Patchett, K. Wilson, K. Bartizal, 1996, The Journal of antibiotics.

Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.

G. Chrebet, J. Hale, S. Mandala, 2004, Bioorganic & medicinal chemistry.

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

G. Chrebet, M. Forrest, H. Rosen, 2004, Bioorganic & medicinal chemistry letters.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.

G. Chrebet, J. Hale, S. Mills, 2006, Bioorganic & medicinal chemistry letters.

Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.

Jeffrey T. Kuethe, J. Demartino, E. Sherer, 2016, Journal of medicinal chemistry.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

S. A. Parent, G. Chrebet, M. Forrest, 2005, Journal of medicinal chemistry.

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, H. Rosen, C. L. Lynch, 2004, Bioorganic & medicinal chemistry letters.

Antimicrobial activity of viridiofungins.

F. Vicente, F. Peláez, J. Onishi, 1997, The Journal of antibiotics.

Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis

J. Balkovec, J. Onishi, C. Douglas, 1994, Antimicrobial Agents and Chemotherapy.

Mode of Action of β‐Lactone 1233A in Candida albicans

G. Garrity, R. Fromtling, B. Pelak, 1988 .

Mode Of Action of L‐660,631 in Candida albicans

G. Garrity, R. Fromtling, B. Pelak, 1988 .

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

M. Erion, D. Kemp, S. Prahalada, 2017, Science.

SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.

G. Chrebet, J. Hale, S. Mills, 2007, Bioorganic & medicinal chemistry letters.

Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase*

M. Garcia-Calvo, H. Bull, C. Gill, 1998, The Journal of Biological Chemistry.

Khafrefungin, a Novel Inhibitor of Sphingolipid Synthesis*

M. Garcia-Calvo, H. Bull, S. Mandala, 1997, The Journal of Biological Chemistry.

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

G. Chrebet, M. Forrest, H. Rosen, 2004, Bioorganic & medicinal chemistry letters.

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.

M. Ferrer, B. Strulovici, S. A. Parent, 2004, Journal of medicinal chemistry.

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

G. Chrebet, P. Váchal, J. Hale, 2006, Bioorganic & Medicinal Chemistry Letters.

2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, C. L. Lynch, J. Hale, 2006, Bioorganic & medicinal chemistry letters.

The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Restricticin, a novel glycine-containing antifungal agent.

R. Schwartz, K. Wilson, R. Fromtling, 1991, The Journal of antibiotics.

2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.

J. Hale, S. Mills, S. Mandala, 2006, Bioorganic & medicinal chemistry letters.

C-terminal Loop Mutations Determine Folding and SecretionProperties of PCSK9

D. Johns, T. Vogt, D. Wisniewski, 2016 .

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, H. Rosen, C. L. Lynch, 2004, Bioorganic & medicinal chemistry letters.