Tong Li

发表

Pen‐2 is dispensable for endoproteolysis of presenilin 1, and nicastrin‐Aph subcomplex is important for both γ‐secretase assembly and substrate recruitment

Xuemin Xu, M. Cui, Yipeng Jin, 2012, Journal of neurochemistry.

Neurobiology of Alzheimer’s Disease

D. Price, P. Wong, A. Savonenko, 2012 .

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes*

P. Wong, P. S. St George-Hyslop, P. Fraser, 2009, The Journal of Biological Chemistry.

Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of γ-Secretase*

H. Wen, D. Price, P. Wong, 2007, Journal of Biological Chemistry.

Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity*

P. Wong, T. Kodama, T. Iwatsubo, 2009, The Journal of Biological Chemistry.

Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study

P. Wong, Hanzhang Lu, E. Barbier, 2021, NMR in biomedicine.

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.

H. Cai, D. Price, P. Wong, 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

H. Wen, D. Price, P. Wong, 2007, The Journal of biological chemistry.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

D. Price, P. Wong, Guojun Ma, 2005, The Journal of Neuroscience.

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

H. Cai, D. Price, P. Wong, 2003, The Journal of Neuroscience.

Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics

D. Price, P. Wong, A. Savonenko, 2010 .

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

H. Wen, D. Price, P. Wong, 2007, The Journal of Neuroscience.

Binding Sites of γ-Secretase Inhibitors in Rodent Brain: Distribution, Postnatal Development, and Effect of Deafferentation

P. Wong, R. Olson, C. Rominger, 2004, The Journal of Neuroscience.

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo

D. Price, P. Wong, S. Sisodia, 2011, PloS one.

Glu332 in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity*

P. Wong, B. de Strooper, A. Tolia, 2008, Journal of Biological Chemistry.

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model

P. Wong, Ashley Lau, K. Braunstein, 2016, Nature Communications.

Amyloid-beta and tau pathologies are both necessary to induce novel stage-specific microglia subtypes during Alzheimer’s disease progression

P. Wong, Ashley Lau, J. Troncoso, 2021, bioRxiv.

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI

Lin Chen, Tong Li, Hanzhang Lu, 2019, NeuroImage.

Alzheimer's Therapeutics: Translation of Preclinical Science to Clinical Drug Development

P. Worley, D. Price, P. Wong, 2012, Neuropsychopharmacology.

Recent progress in Alzheimer's disease: animal models lead the way

Tong Li, 2004 .

Investigation of the contribution of total creatine to the CEST Z‐spectrum of brain using a knockout mouse model

Jiadi Xu, Shuhui Cai, Robert G Weiss, 2017, NMR in biomedicine.

Chapter 21 – Alzheimer Disease

D. Price, P. Wong, A. Savonenko, 2015 .

N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53.

P. Wong, R. Doms, V. Morais, 2006, Biochimica et biophysica acta.

Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes*

P. Wong, Huaxi Xu, N. Nukina, 2004, Journal of Biological Chemistry.

Early detection of Alzheimer’s disease using creatine chemical exchange saturation transfer magnetic resonance imaging

P. Wong, Hanzhang Lu, Jiadi Xu, 2021, NeuroImage.

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

P. Wong, V. Lee, Jeffrey A. Johnson, 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

P. Wong, Huaxi Xu, N. Nukina, 2004, The Journal of biological chemistry.

Accelerated Aβ Deposition in APPswe/PS1ΔE9 Mice with Hemizygous Deletions of TTR (Transthyretin)

P. Wong, V. Lee, Jeffrey A. Johnson, 2007, The Journal of Neuroscience.

A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles

S. Arber, D. Talmage, S. Abe, 2016, The Journal of Neuroscience.

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1*

P. Wong, T. Iwatsubo, Haipeng Cheng, 2009, Journal of Biological Chemistry.

Modeling an Anti-Amyloid Combination Therapy for Alzheimer’s Disease

D. Price, P. Wong, A. Savonenko, 2010, Science Translational Medicine.

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin

D. Price, P. Wong, Po-Min Chiang, 2012, Neurobiology of Aging.

S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1*

P. Wong, T. Iwatsubo, Haipeng Cheng, 2009, Journal of Biological Chemistry.

Modeling an Anti-Amyloid Combination Therapy for Alzheimer’s Disease

D. Price, P. Wong, A. Savonenko, 2010, Science Translational Medicine.