D. Frechilla

发表

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

M. Martín-Martínez, Sergio A Alonso de Diego, M. García-López, 2005, Bioorganic & medicinal chemistry letters.

Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum.

R. Insausti, J. Almendral, A. García-Osta, 2000, Brain research. Molecular brain research.

Effect of p‐Chloroamphetamine on 5‐HT1A and 5‐HT7 Serotonin Receptor Expression in Rat Brain

A. García-Osta, J. del Río, D. Frechilla, 2000, Journal of neurochemistry.

A novel class of cardiotonic agents: synthesis and biological evaluation of pyridazino[4,5-b]indoles with cyclic AMP phosphodiesterases inhibiting properties.

A. Monge, M. Font, I. Aldana, 1993, Journal of pharmaceutical sciences.

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation

M. Cuadrado-Tejedor, A. García-Osta, A. Ricobaraza, 2011, Behavioural Brain Research.

The N‐terminal tripeptide of insulin‐like growth factor‐I protects against β‐amyloid‐induced somatostatin depletion by calcium and glycogen synthase kinase 3β modulation

J. Argente, R. León, Manuela G. López, 2009, Journal of neurochemistry.

Inotropic and Chronotropic Effects of 4‐(4′‐n‐Butylaniline)‐7,8‐dimethoxy‐5H‐pyrimido[5,4–b]indole in Guinea‐pig Atria

A. Monge, M. Font, E. Cenarruzabeitia, 1995, The Journal of pharmacy and pharmacology.

Differential effects of the novel analgesic, S 12813-4, on the spinal release of substance P- and calcitonin gene-related peptide-like materials in the rat

M. Hamon, A. Mauborgne, M. Pohl, 1994, Naunyn-Schmiedeberg’s Archives of Pharmacology.

Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment

Rebeca Martínez-Turrillas, J. Rı́o, D. Frechilla, 2005, Neuropharmacology.

1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)-5H-pyridazino[4,5-b]indole. A new antihypertensive agent

A. Monge, M. Font, I. Aldana, 1991 .

10 Glutamate and Depression

J. Rı́o, D. Frechilla, 2005 .

Glutamate and Depression

J. Rı́o, D. Frechilla, 2005 .

Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus

Rebeca Martínez-Turrillas, J. Rı́o, D. Frechilla, 2002, Neuropharmacology.

NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment

J. del Río, D. Frechilla, S. Moyano, 2004, Psychopharmacology.

Role of Hippocampal CaMKII in Serotonin 5-HT1A Receptor-Mediated Learning Deficit in Rats

J. Rı́o, D. Frechilla, S. Moyano, 2004, Neuropsychopharmacology.

Effect of chronic antidepressant treatment on transcription factor binding activity in rat hippocampus and frontal cortex

J. Rı́o, D. Frechilla, A. Otano, 1998, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Conformationally restricted PACAP27 analogues incorporating type II/II' IBTM beta-turn mimetics. Synthesis, NMR structure determination, and binding affinity.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2001, Bioorganic & medicinal chemistry.

Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo

M. Hamon, M. Pohl, S. Bourgoin, 1993, Brain Research.

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

A. García-Osta, A. Ricobaraza, J. Rı́o, 2009, Neuropsychopharmacology.

Antibodies and Antisense Oligonucleotide for Probing the Distribution and Putative Functions of Central 5-HT6Receptors

L. Lanfumey, R. Insausti, M. Hamon, 1999, Neuropsychopharmacology.

Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases

Philip G. F. Browning, M. Baxter, M. López-Aranda, 2020, Neuroscience.

Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative.

A. Monge, M. Font, I. Aldana, 1992, European journal of pharmacology.

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

L. Schiapparelli, J. Rı́o, Alberto Pérez-Mediavilla, 2009, Neurobiology of Disease.

Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine6 receptors in rat nucleus accumbens by antisense oligonucleotides

L. Cruz-Orive, R. Insausti, A. Insausti, 1999, Neuroscience.

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.

R. Franco, A. García-Osta, A. Ricobaraza, 2012, Journal of Alzheimer's disease : JAD.

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

Jesús Avila, J. Ávila, A. Ricobaraza, 2009, Journal of Alzheimer's Disease.

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

A. García-Osta, A. Ricobaraza, J. Rı́o, 2010, Neuropsychopharmacology.

Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: Surface expression of CaMKII and NMDA receptor subunits

J. Rı́o, D. Frechilla, S. Moyano, 2005, Pharmacology Biochemistry and Behavior.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

L. Pardo, A. Planas, J. Ramos, 2011, Journal of medicinal chemistry.

Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: Correlation with AMPA receptor subunit expression in rat hippocampus

A. Simon, L. Schiapparelli, J. Rı́o, 2006, Neuropharmacology.

Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice: an insight into the pathogenic effects of amyloid-β.

J. del Río, Alberto Pérez-Mediavilla, D. Frechilla, 2011, Journal of Alzheimer's disease : JAD.

Ischemia induces cell proliferation and neurogenesis in the gerbil hippocampus in response to neuronal death

J. Lanciego, J. Rı́o, D. Frechilla, 2008, Neuroscience Research.

Neuroprotective effects of serotonin 5-HT1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF

J. Rı́o, D. Frechilla, P. Salazar-Colocho, 2008, Brain Research.

Serotonin 5‐HT1A receptor blockade enhances Ca2+/calmodulin‐dependent protein kinase II function and membrane expression of AMPA receptor subunits in the rat hippocampus: implications for memory formation

L. Schiapparelli, J. del Río, D. Frechilla, 2005, Journal of neurochemistry.

Differential Regulation by Methylenedioxymethamphetamine of 5‐Hydroxytryptamine1A Receptor Density and mRNA Expression in Rat Hippocampus, Frontal Cortex, and Brainstem: The Role of Corticosteroids

A. García-Osta, J. del Río, B. Lasheras, 1997, Journal of neurochemistry.

Involvement of the vascular wall in regenerative processes after CA1 ischemic neuronal death

J. Rı́o, D. Frechilla, P. Salazar-Colocho, 2008, International Journal of Developmental Neuroscience.

Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) on BDNF mRNA expression in rat frontal cortex and hippocampus

Rebeca Martínez-Turrillas, J. Rı́o, D. Frechilla, 2006, Neuroscience Letters.

Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus.

A. García-Osta, J. del Río, D. Frechilla, 2004, Brain research. Molecular brain research.

Increased in vivo release of calcitonin gene-related peptide-like material from the spinal cord in arthritic rats

M. Hamon, M. Pohl, E. Collin, 1993, Pain.

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2006, Bioorganic & medicinal chemistry letters.

Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs.

Rebeca Martínez-Turrillas, J. del Río, D. Frechilla, 2007, Biochemical and biophysical research communications.

Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model.

J. del Río, Alberto Pérez-Mediavilla, D. Frechilla, 2009, Biochemical and biophysical research communications.

Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone

D. Frechilla, Ana Garcıx0301a-Osta, Joaquıx0301n Del Rıx0301o, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Facilitation by 8‐OH‐DPAT of passive avoidance performance in rats after inactivation of 5‐HT1A receptors

A. García-Osta, J. del Río, S. Ballaz, 1999, British journal of pharmacology.

New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.

M. García-López, R. González-Muñiz, C. Cativiela, 2006, Bioorganic & medicinal chemistry letters.

Serotonin 5‐HT1A receptor expression is selectively enhanced in the striosomal compartment of chronic parkinsonian monkeys

R. Insausti, R. Moratalla, A. Cobreros, 2001, Synapse.

[Perspectives on the amyloid cascade hypothesis of Alzheimer's disease].

J. del Río, D. Frechilla, Ana-María Simón, 2010, Revista de neurologia.

BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons

A. García-Osta, E. Cenarruzabeitia, J. del Río, 2001, Neuroreport.

PACAP27 Analogues Incorporating Type II/II’ β-Turn Mimetics

M. Martín-Martínez, M. García-López, R. González-Muñiz, 2001 .

Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues.

M. García-López, R. González-Muñiz, D. Andreu, 2008, Bioorganic & medicinal chemistry letters.

Neuroprotective effects of serotonin 5-HT1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF

J. Rı́o, D. Frechilla, P. Salazar-Colocho, 2008, Brain Research.

Serotonin 5-HT1A receptor activation prevents phosphorylation of NMDA receptor NR1 subunit in cerebral ischemia

J. del Río, D. Frechilla, P. Salazar-Colocho, 2007, Journal of Physiology and Biochemistry.

Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2004, Bioorganic & medicinal chemistry.

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

M. López-Rodríguez, B. Benhamú, L. Schiapparelli, 2003, Bioorganic & medicinal chemistry letters.