G. Saponaro

发表

Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.

K. Varani, P. Borea, P. Baraldi, 2012, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A₁ adenosine receptor.

K. Varani, O. Cruz-López, F. Vincenzi, 2014, Bioorganic & medicinal chemistry.

Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.

A. Cavalli, M. Recanatini, K. Varani, 2012, Journal of medicinal chemistry.

1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.

K. Varani, A. Zaid, P. Borea, 2008, Bioorganic & medicinal chemistry.

Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models

K. Varani, C. Corciulo, F. Vincenzi, 2013, PAIN®.

Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.

A. IJzerman, K. Varani, L. C. López-Cara, 2014, Journal of medicinal chemistry.

Transient receptor potential ankyrin 1 (TRPA1) antagonists.

A. Szallasi, D. Preti, G. Saponaro, 2015, Pharmaceutical patent analyst.

7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: a promising approach for treating pain and inflammation.

P. Baraldi, R. Romagnoli, S. Baraldi, 2012, Bioorganic & medicinal chemistry.

One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.

K. Varani, F. Vincenzi, P. Borea, 2015, Journal of medicinal chemistry.

Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.

K. Varani, C. Corciulo, F. Vincenzi, 2013, Journal of medicinal chemistry.

7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.

K. Varani, F. Vincenzi, M. Targa, 2012, Journal of medicinal chemistry.

A3 Adenosine Receptor Antagonists: History and Future Perspectives

P. Baraldi, R. Romagnoli, S. Baraldi, 2010 .

Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A₃ adenosine receptor antagonists.

K. Varani, S. Di Maro, L. Marinelli, 2012, Journal of medicinal chemistry.

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

K. Varani, S. Gessi, P. Borea, 2007 .

N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.

K. Varani, S. Gessi, P. Borea, 2007, Bioorganic & Medicinal Chemistry.

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.

Cristina Tintori, Tiziano Tuccinardi, Pier Andrea Borea, 2013, Journal of medicinal chemistry.

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists.

K. Varani, T. Tuccinardi, F. Vincenzi, 2016, European journal of medicinal chemistry.

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH).

T. Tuccinardi, A. Martinelli, P. Baraldi, 2015, European journal of medicinal chemistry.

Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.

M. Botta, K. Varani, T. Tuccinardi, 2008, Bioorganic & medicinal chemistry.

New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.

E. Novellino, K. Varani, A. Zaid, 2011, Journal of medicinal chemistry.

Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models

K. Varani, C. Corciulo, F. Vincenzi, 2013, PAIN®.

Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.

E. Novellino, K. Varani, S. Cosconati, 2015, Journal of medicinal chemistry.