J. Kendall

发表

Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells

W. Denny, S. Ganta, M. Amiji, 2012, Pharmaceutical Research.

Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor.

W. Denny, Meghna Talekar, S. Garg, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Concerning the synthesis and enantioselective rearrangements of episulfoxides

A. J. Blake, A. Blake, Paul A. Cooke, 2000 .

Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy.

W. Denny, S. Ganta, M. Amiji, 2013, International journal of pharmaceutics.

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

W. Denny, G. Rewcastle, C. Buchanan, 2017, The Biochemical journal.

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

C. Buchanan, P. Shepherd, J. Dickson, 2013, PloS one.

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

Claire L. Lill, W. Denny, G. Rewcastle, 2012, Bioorganic & medicinal chemistry.

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR.

Claire L. Lill, K. Y. Tsang, W. Denny, 2012, Bioorganic & medicinal chemistry.

Photosensitized (electron-transfer) deconjugation of 1-arylcyclohexenes.

D. Mangion, D. Arnold, J. Kendall, 2001, Organic letters.

Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine.

B. Palmer, J. Flanagan, L. Ching, 2015, Biochimica et biophysica acta.

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors

W. Denny, G. Rewcastle, P. Shepherd, 2007 .

Biological characterization of SN 32976 , a selective inhibitor of PI 3 K and mTOR with preferential activity to PI 3 K α , in comparison to established pan PI 3 K inhibitors

K. Y. Tsang, G. Rewcastle, D. J. Matthews, 2017 .

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds

W. Denny, G. Rewcastle, C. Buchanan, 2018, Acta Pharmacologica Sinica.

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

G. Rewcastle, W. Han, P. Shepherd, 2011, The Biochemical journal.

Identification of a Unique Co-operative Phosphoinositide 3-Kinase Signaling Mechanism Regulating Integrin αIIbβ3 Adhesive Function in Platelets*

G. Rewcastle, M. Maxwell, C. Gachet, 2007, Journal of Biological Chemistry.

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Shaun P Jackson, W. Denny, G. Rewcastle, 2007, The Biochemical journal.

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

W. Denny, G. Rewcastle, C. Buchanan, 2011, The Biochemical journal.

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

W. Denny, G. Rewcastle, P. Shepherd, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

S. Gamage, W. Denny, G. Rewcastle, 2019, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

K. Y. Tsang, S. Gamage, W. Denny, 2017, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Claire L. Lill, S. Gamage, W. Denny, 2013, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Claire L. Lill, S. Gamage, W. Denny, 2011, Journal of medicinal chemistry.

Targeting of nanoparticles in cancer: drug delivery and diagnostics

W. Denny, Meghna Talekar, S. Garg, 2011, Anti-cancer drugs.

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

K. Y. Tsang, S. Gamage, W. Denny, 2017, Oncotarget.

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.

G. Rewcastle, M. Maxwell, C. Gachet, 2007, The Journal of biological chemistry.

Towards the Diastereoselective Functionalization of Non-Racemic Acetal Derivatives of η6-Arylcarbonyl Complexes of Tricarbonylchromium

J. Kendall, P. D. Woodgate, 1998 .

Rhodium Catalysed S- and SO-Transfer: Novel Syntheses of Norbornane Episulfoxides and Episulfides

N. Simpkins, J. Kendall, 1998 .

Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells

W. Denny, S. Ganta, M. Amiji, 2012 .

High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds

W. Denny, G. Rewcastle, C. Buchanan, 2018, Acta Pharmacologica Sinica.

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.

Julian Blagg, P. Fish, R. Butt, 2007, Journal of medicinal chemistry.

Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: variation of the central linker group

Claire L. Lill, K. Y. Tsang, W. Denny, 2014 .

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors.

Claire L. Lill, K. Y. Tsang, W. Denny, 2017, Bioorganic & medicinal chemistry letters.

Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine.

B. Palmer, J. Flanagan, L. Ching, 2015, Biochimica et biophysica acta.

Abstract 1644: Design and discovery of PWT33597 (VDC-597), a dual inhibitor of PI3-kinase alpha and mTOR

S. Gamage, W. Denny, G. Rewcastle, 2014 .