S. Kikuchi

发表

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.

R. Heath, H. Hashimoto, A. Inoue, 2016, Bioorganic & medicinal chemistry.

Structural basis for the molecular interactions in DNA damage tolerances

H. Hashimoto, A. Hishiki, K. Hara, 2017, Biophysics and physicobiology.

Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture

K. Nagayama, K. Sugie, T. Shiota, 2020, bioRxiv.

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response

K. Nagayama, Mari Nakanishi, N. Isozumi, 2022, Frontiers in Cell and Developmental Biology.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin

C. Canman, A. Inoue, A. Hishiki, 2014 .

Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5

K. Nasmyth, J. Löwe, Hongtao Yu, 2018, Molecular cell.

27‐Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action

S. Takasawa, M. Hasegawa, K. Tsuruya, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

S. Takasawa, M. Hasegawa, K. Tsuruya, 2019, bioRxiv.

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Hongtao Yu, A. Singal, I. Nassour, 2019, Nature Communications.

Mitotic Regulators and the SHP2-MAPK Pathway Promote Insulin Receptor Endocytosis and Feedback Regulation of Insulin Signaling

Hongtao Yu, A. Singal, I. Nassour, 2018, bioRxiv.

Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).

Y. Ishikawa, H. Hashimoto, H. Yokoyama, 2017, The Journal of biological chemistry.

A Missense Mutation in Rev7 Disrupts Formation of Polζ, Impairing Mouse Development and Repair of Genotoxic Agent-induced DNA Lesions*

H. Yamanishi, K. Abe, H. Hashimoto, 2013, The Journal of Biological Chemistry.

Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy

Z. Otwinowski, Hongtao Yu, D. Tomchick, 2016, Proceedings of the National Academy of Sciences.

Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.

Toshiyuki Shimizu, H. Hashimoto, Mamoru Sato, 2012, The Journal of biological chemistry.

Structural Basis for Molecular Interactions in DNA Damage Tolerance

H. Hashimoto, A. Hishiki, K. Hara, 2017 .

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

R. Heath, C. Canman, H. Hashimoto, 2014, The Journal of Biological Chemistry.

Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5

K. Nasmyth, J. Löwe, Hongtao Yu, 2018, Molecular cell.

Multiple interactions between Scc1 and Scc2 activate cohesin’s DNA dependent ATPase and replace Pds5 during loading

K. Nasmyth, J. Löwe, Hongtao Yu, 2017, bioRxiv.

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways

A. Takahashi, M. Hasegawa, G. Kashino, 2020, The Journal of Biological Chemistry.

ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway

A. Takahashi, M. Hasegawa, G. Kashino, 2020, bioRxiv.

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

H. Taguchi, N. Kodera, Mari Nakanishi, 2021, Nature Communications.

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains

T. Saio, O. Shoji, K. Ishimori, 2019 .

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Hongtao Yu, A. Singal, I. Nassour, 2019, Nature Communications.

Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation

Mari Nakanishi, Y. Nishimura, Tatsuhide Tanaka, 2021, Frontiers in Cellular Neuroscience.