K. Kiakos

发表

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitroand in clinical acquired resistant tumour samples

J. Ledermann, C. Craddock, D. Hochhauser, 2012, BMC Cancer.

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.

P. Loadman, J. Hartley, L. Patterson, 2011, Chemical communications.

Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide.

D. Hochhauser, J. Hartley, V. Satam, 2015, Chemistry & biology.

Saccharomyces cerevisiae RAD5 Influences the Excision Repair of DNA Minor Groove Adducts*

Tiffany T. Howard, P. McHugh, J. Hartley, 2002, The Journal of Biological Chemistry.

DNA sequence–selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145

P. McHugh, J. Hartley, A. Sato, 2007, Molecular Cancer Therapeutics.

Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.

Shuo Wang, W. Wilson, J. Hartley, 2013, Bioorganic & medicinal chemistry.

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.

Adrienne E. Scott, Tiffany T. Howard, Luanne M. McNulty, 2002, Bioorganic & medicinal chemistry.

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro.

G. Del Favero, W. Sommergruber, M. Jakupec, 2019, Metallomics : integrated biometal science.

Acetyl analogs of combretastatin A-4: synthesis and biological studies.

J. Hartley, S. Mooberry, Gregory S. Fraley, 2011, Bioorganic & medicinal chemistry.

Molecular and cellular pharmacology of novel chiral and achiral CC-1065/duocarmycin analogues

K. Kiakos, 2007 .

DNA‐Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole

W. Wilson, J. Hartley, V. Satam, 2018, Chembiochem : a European journal of chemical biology.

EFFICIENT SYNTHESIS OF (±)-seco-CYCLOPROPANEINDOLINE ANALOGS OF CC-1065

J. Hartley, S. Roller, P. Burke, 2001 .

A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation.

J. Hartley, J. Kluza, T. Spithill, 2010, Bioorganic & medicinal chemistry.

DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

Carly A. Price, J. Hartley, A. Sato, 2006, Bioorganic & medicinal chemistry letters.

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.

Tiffany T. Howard, Carly A. Price, J. Hartley, 2004, Bioorganic & medicinal chemistry.

Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA.

W. Berger, J. Hartley, M. Jakupec, 2018, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.

Erik C. Madsen, J. Hartley, H. Handl, 2005, Bioorganic & medicinal chemistry letters.

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

O. Gileadi, P. McHugh, N. Burgess-Brown, 2011, Genes & development.

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.

David E Thurston, Konstantinos Kiakos, J. Hartley, 2008, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Two Cytotoxic Analogs of the Novel Pyrrolo[1′,2′:1,2][1,4]diazepin [7,6-b]indol-5(6H)-one Nucleus

J. Hartley, A. Tsotinis, D. Thurston, 2003 .

Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole-imidazole polyamides.

Carly A. Price, J. Hartley, B. Lingerfelt, 2005, Bioorganic & medicinal chemistry letters.

Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides.

Carly A. Price, Erik C. Madsen, J. Hartley, 2002, Bioorganic & medicinal chemistry letters.

Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression.

D. Hochhauser, J. Hartley, B. Keppler, 2021, Bioorganic & medicinal chemistry letters.

Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.

W. Wilson, D. Hochhauser, J. Hartley, 2010, Bioorganic & medicinal chemistry.

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

T. Helleday, R. Wheelhouse, J. Hartley, 2012, Biochemical pharmacology.

DNA recognition: design, synthesis and biophysical characteristics of pyrrole(H) based polyamides.

W. Wilson, J. Hartley, L. Westrate, 2010, Medicinal chemistry (Shariqah (United Arab Emirates)).

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

C. Galmarini, M. D’Incalci, E. Erba, 2015, British Journal of Cancer.

Treatment with Gefitinib or Lapatinib Induces Drug Resistance through Downregulation of Topoisomerase IIα Expression

A. Makris, D. Hochhauser, J. Hartley, 2013, Molecular Cancer Therapeutics.

DOWNREGULATION OF TOPOISOMERASE IIα EXPRESSION

A. Makris, D. Hochhauser, J. Hartley, 2013 .

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases

C. Allerston, O. Gileadi, P. McHugh, 2012, The Journal of Biological Chemistry.

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.

M. Gregory, W. Wilson, D. Hochhauser, 2017, Biochimica et biophysica acta. Gene regulatory mechanisms.

AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.

Shuo Wang, W. Wilson, J. Hartley, 2015, Bioorganic & medicinal chemistry letters.

Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.

Sharjeel A. Tahir, Ryan S. Davis, W. Wilson, 2011, Biochemistry.

Nuclear Localization andGene ExpressionModulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide Graphical Abstract Highlights

D. Hochhauser, J. Hartley, V. Satam, 2015 .

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.

T. Marafioti, J. Hartley, P. V. van Berkel, 2018, Blood.

Abstract 1766: Persistence of drug-induced DNA interstrand cross-links distinguishes bendamustine from conventional DNA cross-linking agents

D. Hochhauser, V. Spanswick, J. Hartley, 2012 .

Affinity and kinetic modulation of polyamide-DNA interactions by N-modification of the heterocycles.

Shuo Wang, W. Wilson, J. Hartley, 2013, Biopolymers.

Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

D. Hochhauser, J. Hartley, R. Jia, 2015, Journal of the National Cancer Institute.

Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.

J. Hartley, V. Satam, Yang Liu, 2012, Bioorganic & Medicinal Chemistry.

Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI.

Ryan S. Davis, J. Hartley, David F. Wilson, 2011, Biochemical and biophysical research communications.

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples

J. Ledermann, C. Craddock, D. Hochhauser, 2012, BMC Cancer.

A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.

J. Hartley, Moses Lee, W. Pennington, 2005, Medicinal chemistry.

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR

R. Wheelhouse, R. Phillips, N. Karodia, 2015 .

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro.

G. Del Favero, W. Sommergruber, M. Jakupec, 2019, Metallomics : integrated biometal science.

The University of Bradford Institutional Repository

R. Wheelhouse, N. Karodia, E. A. Garelnabi, 2016 .