M. Takano

发表

Potent 19-norvitamin D analogs for prostate and liver cancer therapy.

A. Yoshida, Tai C. Chen, T. Sakaki, 2012, Future medicinal chemistry.

Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells.

K. Yasuda, S. Ikushiro, T. Sakaki, 2015, Bioconjugate chemistry.

New C15-substituted active vitamin D3.

M. Takimoto-Kamimura, D. Sawada, Nozomi Saito, 2011, Organic letters.

1α,25(OH)2D3 Analog, MART-10, Inhibits Neuroendocrine Tumor Cell Metastasis After VEGF-A Stimulation.

H. Juang, J. Pang, T. Yeh, 2017, Anticancer research.

C15-functionalized 16-ene-1α,25-dihydroxyvitamin D3 is a new vitamin D analog with unique biological properties.

M. Takimoto-Kamimura, Tai-Chi Chen, D. Sawada, 2012, Anticancer research.

Synthesis and biological activities of 14-epi-MART-10 and 14-epi-MART-11: implications for cancer and osteoporosis treatment.

Y. Harada, T. Sugiura, S. Ikushiro, 2009, Anticancer research.

Synthesis of 2alpha-substituted-14-epi-previtamin D3 and its genomic activity.

D. Sawada, Nozomi Saito, A. Kittaka, 2009, Bioorganic & medicinal chemistry letters.

Pre-stroke habitual prolonged sleep as a predictor for post-stroke sleep quality, stroke-related quality of life, and lifestyle values

M. Yasujima, T. Osanai, Toshiko Tomisawa, 2021, Journal of Clinical Neuroscience.

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

K. Yasuda, S. Ikushiro, T. Sakaki, 2022, Scientific Reports.

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

K. Yasuda, S. Ikushiro, T. Sakaki, 2021, International journal of molecular sciences.

Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage.

Y. Imamura, K. Kuwata, M. Kurihara, 2016, Chemical & pharmaceutical bulletin.

β-PNA: peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone.

Y. Imamura, M. Kurihara, A. Kittaka, 2011, Bioorganic & medicinal chemistry letters.

Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 by CYP24A1 and biological activity of its 24R-hydroxylated metabolite

K. Yasuda, S. Ikushiro, T. Sakaki, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D3 analogs

K. Yasuda, S. Ikushiro, Tai C. Chen, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Enantioselective total synthesis of (-)-erinacine B.

M. Nakada, M. Takano, Hiroyuki Ishikawa, 2007, Organic letters.

Reaction of dianions of acetoacetic esters with epibromohydrin derivatives: a novel synthesis of tetrahydrofuran derivatives and tetrahydropyran derivatives

Masahisa Nakada, Yukitaka Iwata, Masashi Takano, 1999 .

Asymmetric Catalysis on the Intramolecular Cyclopropanation of α-Diazo-β-keto Sulfones

Masayuki Utsugi, M. Nakada, M. Takano, 2003 .

Synthetic studies on cyathins: enantioselective total synthesis of (+)-allocyathin B2.

M. Nakada, M. Takano, Akinori Umino, 2004, Organic letters.

Synthesis, metabolism, and biological activity of 2-[3-(tetrazolyl)propyl]-1α,25-dihydroxy-19-norvitamin D3

K. Yasuda, T. Sakaki, A. Kittaka, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1α,25-Dihydroxyvitamin D3 in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells

H. Juang, L. Su, J. Pang, 2012, Evidence-based complementary and alternative medicine : eCAM.

19-Nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells

H. Juang, C. Yeh, Tai C. Chen, 2011, Steroids.

MART-10, the new brand of 1α,25(OH)2D3 analog, is a potent anti-angiogenic agent in vivo and in vitro

Chi-Ying F. Huang, H. Juang, T. Yeh, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

MART-10 represses cholangiocarcinoma cell growth and high vitamin D receptor expression indicates better prognosis for cholangiocarcinoma

M. Hsiao, H. Juang, T. Yeh, 2017, Scientific Reports.

1α,25(OH)2D3 Analog, MART-10, Inhibits Neuroendocrine Tumor Cell Growth Through Induction of G0/G1 Cell-cycle Arrest and Apoptosis.

Tsui-hsia Feng, H. Juang, T. Yeh, 2016, Anticancer research.

The Vitamin D Analog, MART-10, Attenuates Triple Negative Breast Cancer Cells Metastatic Potential

H. Juang, T. Yeh, C. Yeh, 2016, International journal of molecular sciences.

The vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells.

Y. Jan, H. Juang, T. Yeh, 2014, Cancer letters.

MART-10, a less calcemic vitamin D analog, is more potent than 1α,25-dihydroxyvitamin D3 in inhibiting the metastatic potential of MCF-7 breast cancer cells in vitro

H. Juang, C. Yeh, J. Hsu, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

MART-10, a 1α,25(OH)2D3 Analog, Potently Represses Metastasis of ER+ Breast Cancer Cells with VEGF-A Overexpression

H. Juang, T. Yeh, Ming-Huang Chen, 2018, AntiCancer Research.

Evaluation of the potential therapeutic role of a new generation of vitamin D analog, MART-10, in human pancreatic cancer cells in vitro and in vivo

H. Juang, T. Yeh, C. Yeh, 2013, Cell cycle.

[Recent progress of study on vitamin D analogs].

Nozomi Saito, A. Kittaka, M. Takano, 2006, Clinical calcium.

MART-10, the vitamin D analog, is a potent drug to inhibit anaplastic thyroid cancer cell metastatic potential.

H. Juang, C. Yeh, Tai-Chi Chen, 2015, Cancer letters.

Total Synthesis of (+)-Allocyathin B2, (-)-Erinacine B, and (-)-Erinacine E

M. Nakada, M. Takano, Hideaki Watanabe, 2008 .

MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase

H. Juang, J. Flanagan, Shih-Wei Yang, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

MART-10, a newly synthesized vitamin D analog, represses metastatic potential of head and neck squamous carcinoma cells

H. Juang, Shih-Wei Yang, C. Yeh, 2016, Drug design, development and therapy.

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator.

S. Ikushiro, T. Sakaki, A. Kittaka, 2018, Biochemical and biophysical research communications.

Development of Catalytic Asymmetric Intramolecular Cyclopropanation of α-Diazo-β-Keto Sulfones and Applications to Natural Product Synthesis

M. Nakada, M. Takano, H. Takeda, 2009 .

STUDIES ON THE SYNTHESIS AND METABOLISM OF 14-epi-2α-(3-HYDROXYPROPYL)-19-NORVITAMIN D3 AND ITS 2β-ISOMER

K. Yasuda, Tai-Chi Chen, T. Sakaki, 2010 .

Synthesis and preliminary biological evaluation of 2-[3-(tetrazolyl)propyl]-1α,25-dihydroxy-19-norvitamin D3

K. Hirano, D. Sawada, A. Kittaka, 2015 .

Vitamin D Analogs with Nitrogen Atom at C2 Substitution and Effect on Bone Formation.

H. Saitoh, A. Kittaka, M. Takano, 2016, Vitamins and hormones.

Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D3

K. Yasuda, Tai C. Chen, T. Sakaki, 2015, Journal of Steroid Biochemistry and Molecular Biology.

Synthesis and biological activity of 1α,2α,25-trihydroxyvitamin D3: active metabolite of 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP3A4.

K. Yasuda, T. Sakaki, D. Sawada, 2014, Chemical & pharmaceutical bulletin.

Synthesis of 2α-heteroarylalkyl active vitamin d3 with therapeutic effect on enhancing bone mineral density in vivo.

Y. Harada, M. Takimoto-Kamimura, D. Sawada, 2013, ACS medicinal chemistry letters.

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor

K. Yasuda, S. Ikushiro, T. Sakaki, 2017, The Journal of Steroid Biochemistry and Molecular Biology.

MART-10, the new brand of 1α,25(OH)2D3 analog, is a potent anti-angiogenic agent in vivo and in vitro

Chi-Ying F. Huang, H. Juang, T. Yeh, 2016, The Journal of Steroid Biochemistry and Molecular Biology.

19-Nor-2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (MART-10) is a potent cell growth regulator with enhanced chemotherapeutic potency in liver cancer cells

H. Juang, C. Yeh, Tai C. Chen, 2011, Steroids.