Jia Li

发表

Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.

E. Behrens, Z. Arany, C. Biswas, 2019, JCI insight.

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

F. Nan, Jingya Li, Yu Xiao, 2018, Acta Pharmacologica Sinica.

Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Hong Liu, Jiang Wang, Jingya Li, 2019, European journal of medicinal chemistry.

BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase

Donghai Wu, Shouguang Jin, Jingya Li, 2012, PloS one.

The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling

Lihong Hu, Haowen Jiang, Jingya Li, 2020, Cell Death & Disease.

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

M. Gu, F. Nan, Jingya Li, 2018, Acta Pharmacologica Sinica.

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Haowen Jiang, Jingya Li, Jia Li, 2020, Acta Pharmacologica Sinica.

AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D*

F. Nan, Yi Zang, Lifang Yu, 2009, Journal of Biological Chemistry.

AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase*

F. Nan, T. Wen, Yi Zang, 2008, Journal of Biological Chemistry.

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Jing Fang, Jingya Li, B. Song, 2019, Nature Communications.

Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

Weiliang Zhu, Zhijian Xu, Cheng Peng, 2021, Acta Pharmacologica Sinica.

Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.

M. Gu, F. Nan, Xing-zu Zhu, 2006, Journal of medicinal chemistry.

Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic β-Cells*

Xiao Han, J. Nie, Q. Liang, 2012, The Journal of Biological Chemistry.

Alstonlarsines A-D, Four Rearranged Indole Alkaloids from Alstonia scholaris.

Jiang-Ping Wu, J. Yue, Lei Xu, 2019, Organic letters.

Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species*

F. Nan, Jun-qing Du, Jian Ding, 2008, Journal of Biological Chemistry.

Isoquinoline‐1,3,4‐trione and its derivatives attenuate β‐amyloid‐induced apoptosis of neuronal cells

F. Nan, Jia Li, Jingya Li, 2006, The FEBS journal.

Mutations at the S1 Sites of Methionine Aminopeptidases from Escherichia coli and Homo sapiens Reveal the Residues Critical for Substrate Specificity*

M. Gu, F. Nan, Q. Ye, 2004, Journal of Biological Chemistry.

Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis.

B. Han, Jie Tang, Lei Xu, 2017, European journal of medicinal chemistry.

Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin.

F. Nan, Xing-zu Zhu, Wen-Wei Qiu, 2006, Bioorganic & medicinal chemistry letters.

Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

Jia Li, Jian-jun Yang, Jingya Li, 2010 .

Glutamine fuels proliferation but not migration of endothelial cells

Cholsoon Jang, Z. Arany, Boa Kim, 2017, The EMBO journal.

Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

M. Gu, Yuan-yuan Li, Chunmei Xia, 2013, Diabetes.

Novel Small-Molecule PGC-1 a Transcriptional Regulator With Bene fi cial Effects on Diabetic db / db Mice

M. Gu, Yuan-yuan Li, Chunmei Xia, 2012 .

New alkaloids from Daphniphyllum himalense

Jia Li, J. Yue, Jingya Li, 2016 .

Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.

Jia Li, Jie Tang, Li-xin Gao, 2012, Bioorganic & medicinal chemistry letters.

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells*

M. Gu, F. Nan, Lifang Yu, 2008, Journal of Biological Chemistry.

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

D. James, N. Turner, G. Cooney, 2008, Diabetes.

Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue

F. Nan, Haowen Jiang, Bo-Han Li, 2020, Acta Pharmacologica Sinica.

A genome‐scale TF–DNA interaction network of transcriptional regulation of Arabidopsis primary and specialized metabolism

D. Kliebenstein, S. Brady, M. Tang, 2021, bioRxiv.

1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors

F. Nan, Bainian Feng, Li-xin Gao, 2013, Molecules.

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

F. Nan, Yu Xiao, Yu-ting Lu, 2018, Acta Pharmacologica Sinica.

A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors*

Ping Huang, H. Ying, Mengle Shao, 2012, The Journal of Biological Chemistry.

A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice

N. Turner, M. Gu, Fajun Nan, 2009 .

Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro.

F. Nan, Haowen Jiang, An-hui Gao, 2014, Biochimica et biophysica acta.

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles.

Ling-Ling Yang, Liang Chang, Jie Tang, 2014, European journal of medicinal chemistry.

8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models.

M. Gu, Jia Li, Jingya Li, 2010, Bioorganic & medicinal chemistry.

Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.

M. Gu, F. Nan, Jingya Li, 2006, Biochimica et biophysica acta.

Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

Jia Li, Qian Li, Yingjie Jiang, 2005 .

Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

Q. Shen, Jian-bin Zheng, H. Dai, 2011 .

Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.

Jia Li, Li-xin Gao, Ying Yang, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Novel Indolin-2-one Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors.

Q. Shen, Jian-bin Zheng, H. Dai, 2012 .

Conserved α-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase α Subunits*

Tao Pang, Bing Xiong, B. Xiong, 2007, Journal of Biological Chemistry.

Specificity for inhibitors of metal-substituted methionine aminopeptidase.

F. Nan, Jia Li, Q. Ye, 2003, Biochemical and biophysical research communications.

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

F. Zhang, Ling-Ling Yang, Dong-mei Chen, 2015, Acta Pharmacologica Sinica.

Synthesis and biological evaluation of novel 2,3-pyrazole ring-substituted-4,4-dimethyl lithocholic acid derivatives as selective protein tyrosine phosphatase 1B (PTP1B) inhibitors with cellular efficacy

Li-xin Gao, Fan Yang, Lifang Yu, 2015 .

AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models

F. Nan, Haowen Jiang, Yang-ming Zhang, 2020, Acta Pharmacologica Sinica.

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

M. Gu, F. Nan, Haowen Jiang, 2013, Toxicology and applied pharmacology.

KCNQ1OT1/miR-18b/HMGA2 axis regulates high glucose-induced proliferation, oxidative stress, and extracellular matrix accumulation in mesangial cells

L. Bai, Jia Li, Mingming Li, 2020, Molecular and cellular biochemistry.

Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening

Lei Shi, Hai-ping Yu, Q. Shen, 2008, Acta Pharmacologica Sinica.

Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice

M. Gu, Lei Xu, Yuan-yuan Li, 2013, PloS one.

Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.

F. Nan, Li-xin Gao, Wei-Ping Ma, 2013, European journal of medicinal chemistry.

Novel grayanane diterpenoids from Rhododendron principis

Jia Li, Jingya Li, A. Hou, 2014 .

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.

F. Nan, Q. Ye, Qun-Li Luo, 2005, Bioorganic & medicinal chemistry letters.

Activity‐Based Protein Profiling for Type I Methionine Aminopeptidase by Using Photo‐Affinity Trimodular Probes

F. Nan, Wen-Wei Qiu, Jie Xu, 2007, Chembiochem : a European journal of chemical biology.

Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives.

F. Nan, Q. Ye, L. Chen, 2005, Bioorganic & medicinal chemistry letters.

Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.

Hongyu Zhao, K. White, Dongjun Chung, 2016, Molecular cell.

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

M. Gu, F. Nan, Yang-ming Zhang, 2018, Acta Pharmacologica Sinica.

Novel Grayanane Diterpenoids from Rhododendron principis.

A. Hou, Li-xin Gao, Chun Lei, 2014 .

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.

Y. Long, Li-xin Gao, Yi Jin, 2014, Bioorganic & medicinal chemistry.

Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1beta.

F. Nan, Jun-qing Du, Hai-ping Yu, 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.

F. Nan, Jian Yin, Ying Li, 2014, Organic & biomolecular chemistry.

Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation

M. Gu, Haowen Jiang, Jia Li, 2019, Diabetes.

PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism

Yong Liu, J. Han, Mengle Shao, 2011, Proceedings of the National Academy of Sciences.

Synthesis of Novel 3‐aryl‐1‐oxa‐2,8‐diazaspiro[4.5]dec‐2‐ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B

Bainian Feng, Li-xin Gao, Li Sheng, 2015, Chemical biology & drug design.

Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent.

F. Nan, Q. Ye, Jia Li, 2005, Bioorganic & medicinal chemistry letters.

Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes.

F. Nan, Q. Ye, L. Chen, 2004, Bioorganic & medicinal chemistry.

High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

M. Gu, Yuan-yuan Li, Jia Li, 2009, Diabetes.