N. Sankaranarayanan

发表

Rigorous Analysis of Free Solution Glycosaminoglycan Dynamics Using Simple, New Tools.

U. Desai, Balaji Nagarajan, N. Sankaranarayanan, 2020, Glycobiology.

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules

U. Desai, B. Patel, Balaji Nagarajan, 2017, PloS one.

Studies on fragment-based design of allosteric inhibitors of human factor XIa.

U. Desai, Rio S Boothello, Rami A. Al-Horani, 2020, Bioorganic & medicinal chemistry.

2‐O, 3‐O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity

U. Desai, Shuo Zheng, J. Voynow, 2017, American journal of respiratory cell and molecular biology.

Tamarind xyloglucan attenuates dextran sodium sulfate induced ulcerative colitis: Role of antioxidation

U. Desai, Ming-Yie Liu, S. Periasamy, 2018 .

Combinatorial Virtual Library Screening Study of Transforming Growth Factor-β2–Chondroitin Sulfate System

U. Desai, Balaji Nagarajan, N. Sankaranarayanan, 2021, International journal of molecular sciences.

Mucoadhesive role of tamarind xyloglucan on inflammation attenuates ulcerative colitis.

U. Desai, Ming-Yie Liu, S. Periasamy, 2018, Journal of functional foods.

Transforming growth factor-β2 is sequestered in preterm human milk by chondroitin sulfate proteoglycans.

U. Desai, P. Meier, Aloka L. Patel, 2015, American journal of physiology. Gastrointestinal and liver physiology.

Milk by Chondroitin Sulfate Proteoglycans 2

U. Desai, Aloka L. Patel, S. Garzon, 2015 .

CS proteoglycans sequester TGF-β 2 in milk 1 Transforming Growth Factor-β 2 is sequestered in Preterm Human 1 Milk by Chondroitin Sulfate Proteoglycans

U. Desai, Aloka L. Patel, S. Garzon, 2015 .

In-Depth Molecular Dynamics Study of All Possible Chondroitin Sulfate Disaccharides Reveals Key Insight into Structural Heterogeneity and Dynamism

U. Desai, Balaji Nagarajan, N. Sankaranarayanan, 2022, Biomolecules.

Heparin interaction with a receptor on hyperglycemic dividing cells prevents intracellular hyaluronan synthesis and autophagy responses in models of type 1 diabetes.

U. Desai, V. Hascall, D. Templeton, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics.

U. Desai, V. Tiwari, N. Sankaranarayanan, 2018, ACS medicinal chemistry letters.

Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues.

U. Desai, Maritza V Quintero, Rio S Boothello, 2015, ACS chemical biology.

A synthetic glycosaminoglycan mimetic blocks HSV‐1 infection in human iris stromal cells

U. Desai, M. Volin, V. Tiwari, 2019, Antiviral research.

Discovering small-molecule therapeutics against SARS-CoV-2

U. Desai, V. Tiwari, N. Sankaranarayanan, 2020, Drug Discovery Today.

Perspective on computational simulations of glycosaminoglycans

Balaji Nagarajan, Nehru Viji Sankaranarayanan, Umesh R Desai, 2018, Wiley interdisciplinary reviews. Computational molecular science.

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity

R. Doebele, A. Le, U. Desai, 2021, Neoplasia.

Molecular Dynamics Simulations of Glycosaminoglycan Oligosaccharide Using Newer Force Fields

U. Desai, Balaji Nagarajan, N. Sankaranarayanan, 2019, bioRxiv.

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.

U. Desai, J. Voynow, Shravan Morla, 2019, Journal of medicinal chemistry.

Molecular principles for heparin oligosaccharide–based inhibition of neutrophil elastase in cystic fibrosis

B. Rubin, U. Desai, Shuo Zheng, 2018, The Journal of Biological Chemistry.

So you think computational approaches to understanding glycosaminoglycan-protein interactions are too dry and too rigid? Think again!

Nehru Viji Sankaranarayanan, Umesh R Desai, Balaji Nagarajan, 2018, Current opinion in structural biology.

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

U. Desai, N. Sankaranarayanan, Daniel K. Afosah, 2017, Journal of medicinal chemistry.

Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors.

U. Desai, N. Sankaranarayanan, Daniel K. Afosah, 2023, Journal of medicinal chemistry.

Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor

U. Desai, Rio S Boothello, Jyothi C. Sistla, 2022, Angewandte Chemie.

On the Selectivity of Heparan Sulfate Recognition by SARS-CoV-2 Spike Glycoprotein

U. Desai, N. Sankaranarayanan, C. O'Hara, 2021, ACS medicinal chemistry letters.

Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling.

Nehru Viji Sankaranarayanan, Aurijit Sarkar, Umesh R Desai, 2015, Methods in molecular biology.

Toward a robust computational screening strategy for identifying glycosaminoglycan sequences that display high specificity for target proteins.

U. Desai, N. Sankaranarayanan, 2014, Glycobiology.

Computerized Molecular Modeling for Discovering Promising Glycosaminoglycan Oligosaccharides that Modulate Protein Function.

U. Desai, N. Sankaranarayanan, 2022, Methods in molecular biology.

Molecular dynamics simulations to understand glycosaminoglycan interactions in the free- and protein-bound states.

U. Desai, Balaji Nagarajan, N. Sankaranarayanan, 2022, Current opinion in structural biology.

FIGURES FOR : Solution structure of CXCL 13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

U. Desai, F. Baleux, R. Vivès, 2017 .

Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3-O-Sulfotransferase 1☆

U. Desai, Yiling Bi, B. Kuberan, 2020, Computational and structural biotechnology journal.