Tohru Takashi

发表

Improvement of pulmonary function by oral treatment with a VLA-4 antagonist in a mouse asthmatic model.

M. Yokoyama, G. Takayama, Keiko Matsumoto, 2013, Journal of pharmacological sciences.

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2013, Bioorganic & medicinal chemistry.

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2012, Bioorganic & medicinal chemistry.

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2009, Bioorganic & medicinal chemistry.

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.

J. Chiba, M. Yokoyama, A. Satoh, 2007, Bioorganic & medicinal chemistry.

4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.

T. Horiuchi, J. Chiba, M. Yokoyama, 2006, Chemical & pharmaceutical bulletin.

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

J. Chiba, M. Yokoyama, J. Baldwin, 2006, Bioorganic & medicinal chemistry.

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.

J. Chiba, M. Yokoyama, A. Satoh, 2009, Journal of medicinal chemistry.

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

J. Chiba, M. Yokoyama, J. Baldwin, 2005, Bioorganic & medicinal chemistry letters.