R N Upton

Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development

D R Mould, R N Upton, D. Mould, 2012, CPT: pharmacometrics & systems pharmacology.

A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables.

R N Upton, R. Upton, G. Ludbrook, 1997, British journal of anaesthesia.

The two-compartment recirculatory pharmacokinetic model--an introduction to recirculatory pharmacokinetic concepts.

R N Upton, R. Upton, 2004, British journal of anaesthesia.

Recirculatory model of fentanyl disposition with the brain as the target organ.

R N Upton, R. Upton, C. Grant, 2004, British journal of anaesthesia.

Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration.

R N Upton, R. Upton, C. Grant, 1999, Anesthesia and analgesia.

A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements.

R N Upton, R. Upton, G. Ludbrook, 1997, British journal of anaesthesia.