Xueqing Wang

The granular chloride channel ClC-3 is permissive for insulin secretion.

V. Bindokas, L. Philipson, D. Jacobson, 2009, Cell metabolism.

An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function

M. Gentzsch, D. Nelson, S. Shears, 2008, Current Biology.

Discovery and SAR of 4-Aminopyrrolidine-2-carboxylic Acid Correctors of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, A. Swensen, Ashvani K. Singh, 2022, Bioorganic & medicinal chemistry letters.

Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR.

P. Kym, Xueqing Wang, M. Pizzonero, 2018, Progress in medicinal chemistry.

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222

C. Tse, D. Cyr, A. Swensen, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2018, Journal of medicinal chemistry.

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2019, ACS medicinal chemistry letters.

Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production.

Ryan A McClure, R. Mathew, T. Kinoshita, 2022, ACS chemical biology.