G. Chiu

发表

The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

T. Branchek, H. Lepor, E. Shapiro, 1994, Molecular pharmacology.

Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.

S. Emanuel, R. Lin, P. Connolly, 2007, Bioorganic & medicinal chemistry letters.

Synthesis, In Vitro Activities of (2-Cyclopropoxyphenyl)piperidine Derivatives for α1a and α1d Adrenergic Receptor Inhibitors

P. Connolly, S. Middleton, V. Pulito, 2009 .

(Phenylpiperidinyl)cyclohexylsulfonamides: development of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).

P. Connolly, S. Middleton, V. Pulito, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

S. Emanuel, R. H. Gruninger, R. Lin, 2007, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors.

S. Emanuel, R. Lin, Angel R. Fuentes-Pesquera, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.

R. Chang, P. Kling, B. Lagu, 1999, Journal of medicinal chemistry.

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists.

R. Chang, B. Lagu, C. Forray, 2000, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia

R. Chang, T. Branchek, C. Forray, 1998 .

1-Arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones as potent and selective alpha-1a/1d adrenergic receptor ligands.

P. Connolly, S. Middleton, V. Pulito, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel dihydropyridine alpha-1a antagonists.

R. Chang, C. Forray, W. Wong, 1999, Bioorganic & medicinal chemistry letters.

α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms

P. Connolly, S. Middleton, A. Reitz, 2008 .

Design and Synthesis of an α1a‐Adrenergic Receptor Subtype‐Selective Antagonist from BE2254

C. Forray, C. Gluchowski, G. Chiu, 2006, Chemical Biology and Drug Design.

(Phenylpiperazinyl)cyclohexylureas: discovery of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).

P. Connolly, S. Middleton, V. Pulito, 2008, Bioorganic & medicinal chemistry letters.

Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS).

P. Connolly, S. Middleton, Sean X Peng, 2007, Bioorganic & medicinal chemistry letters.

(Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS).

P. Connolly, S. Middleton, V. Pulito, 2007, Bioorganic & medicinal chemistry letters.

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

T. Branchek, H. Lepor, P. Vaysse, 1998, Journal of medicinal chemistry.

Modeling and mutagenesis of the human alpha 1a-adrenoceptor: orientation and function of transmembrane helix V sidechains.

T. Branchek, H. Nakanishi, D. Craig, 1996, Receptors & channels.

R3487/MEM 3454, a novel nicotinic alpha 7 receptor partial agonist, improves attention and working memory performance in cynomolgus macaques

L. Santarelli, T. Wallace, R. Porter, 2009 .