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Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics

J. Pandit, R. Obach, Ji-Young Kim, 2013 .

PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, Bioorganic & medicinal chemistry letters.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

R. J. Mather, Anne W. Schmidt, R. Hurst, 2010, Journal of medicinal chemistry.

Design and synthesis of pyridazinone-based 5-HT(2C) agonists.

M. Andrews, K. Liu, G. McMurray, 2009, Bioorganic & medicinal chemistry letters.

7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.

A. Brown, P. Fish, Lee R. Roberts, 2009, Bioorganic & medicinal chemistry letters.

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Gregory W. Kauffman, David S. Ramirez, L. Pustilnik, 2017, MedChemComm.

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides.

Jeffrey B. Sperry, Hua Zhou, L. R. Hoth, 2018, Organic letters.

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.

Gregory W. Kauffman, L. Pustilnik, A. Stepan, 2015, Bioorganic & medicinal chemistry letters.

A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction.

Ji-Young Kim, P. Verhoest, Laura A McAllister, 2011, The Journal of organic chemistry.

Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.

J. Pandit, Ji-Young Kim, P. Verhoest, 2013, ACS medicinal chemistry letters.

Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids

Roger M. Howard, Aaron C. Smith, Lixia Yang, 2020 .

Synthesis of ortho-substituted nitroaromatics via improved Negishi coupling conditions

Ji-Young Kim, P. Verhoest, Jaclyn L Henderson, 2011 .

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

J. Pandit, Ji-Young Kim, M. Hayward, 2012, ACS medicinal chemistry letters.

Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.

P. Verhoest, C. Steppan, Travis T Wager, 2020, Cell chemical biology.

1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.

A. Ganong, F. Tingley, J. Siuciak, 2011, Journal of medicinal chemistry.

Design and synthesis of pyridazinone-based 5-HT(2C) agonists.

M. Andrews, K. Liu, G. McMurray, 2009, Bioorganic & Medicinal Chemistry Letters.

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Gregory W. Kauffman, L. Pustilnik, É. Hajós‐Korcsok, 2024, Journal of medicinal chemistry.

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Gregory W. Kauffman, David S. Ramirez, L. Pustilnik, 2017, MedChemComm.