José R. Perez

发表

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

Daniel J. O'Connell, R. Kolde, R. Xavier, 2017, Nature chemical biology.

Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway.

Julie L. Engers, Andrew S. Felts, Brittney S. Bates, 2012, Bioorganic & medicinal chemistry letters.

High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.

D. Altshuler, P. Clemons, V. Dancík, 2015, Cell metabolism.

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.

Jeremy R. Duvall, S. Schreiber, Ana Rodriguez, 2014, ACS medicinal chemistry letters.

Identification of Diversity-Oriented Synthesis Derived Small Molecule, ML341, with Cidal Activity Against Trypanosoma cruzi

Ana Rodriguez, J. Gut, B. Muñoz, 2013 .

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

S. Schreiber, M. Foley, M. Palmer, 2012, ACS medicinal chemistry letters.

Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway

Jeremy R. Duvall, S. Schreiber, A. Shamji, 2013, Journal of the American Chemical Society.

Identification of Inhibitors of PvdQ, an Enzyme Involved in the Synthesis of the Siderophore Pyoverdine

S. Schreiber, B. Muñoz, M. Palmer, 2014, ACS chemical biology.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Joshua A. Bittker, M. Daly, R. Xavier, 2017, Proceedings of the National Academy of Sciences.

The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay

S. Schreiber, B. Muñoz, M. Palmer, 2013 .

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

Patrick W. Faloon, Jen Q. Pan, F. A. Schroeder, 2018, ACS chemical biology.

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.

Joshua A Bittker, Joshua A. Bittker, B. Posner, 2018, ACS chemical biology.

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

Joshua A. Bittker, Carol A. Mulrooney, S. Schreiber, 2018, ACS Infectious Diseases.

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

Joshua A. Bittker, Carol A. Mulrooney, S. Schreiber, 2018, bioRxiv.

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo.

R. Xavier, S. Schreiber, A. Shamji, 2016, ACS chemical biology.

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

Daniel J. O'Connell, R. Xavier, S. Schreiber, 2014, Proceedings of the National Academy of Sciences.

Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.

Jeremy R. Duvall, Julien C. Vantourout, M. Foley, 2018, MedChemComm.

Identification of a selective small molecule inhibitor of breast cancer stem cells.

E. Lander, S. Schreiber, Piyush B. Gupta, 2012, Bioorganic & medicinal chemistry letters.

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.

P. McCarren, C. Garvie, M. Mesleh, 2017, Biochemistry.

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Jeremy R. Duvall, A. Subramanian, M. Foley, 2015, PloS one.

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, ACS medicinal chemistry letters.

Phenotypic High-Throughput Screening Elucidates Target Pathway in Breast Cancer Stem Cell–Like Cells

Lynn VerPlank, B. Muñoz, M. Palmer, 2012, Journal of biomolecular screening.

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

E. Lander, S. Schreiber, Piyush B. Gupta, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway

Julie L. Engers, Andrew S. Felts, Brittney S. Bates, 2013 .

Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells

Jeremy R. Duvall, S. Schreiber, B. Wagner, 2011 .

Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression

Jeremy R. Duvall, A. Subramanian, M. Foley, 2015, PloS one.

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.

Patrick W. Faloon, S. Schreiber, M. Krieger, 2015, Bioorganic & medicinal chemistry letters.

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

Joshua A. Bittker, M. Daly, R. Xavier, 2017, Proceedings of the National Academy of Sciences.

Assay Design for High‐Throughput Screening

Frank W. An, Jose R. Perez, F. An, 2013 .