J. Hwang

发表

Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.

Inhee Choi, Jinhwa Lee, M. Windisch, 2013, Bioorganic & medicinal chemistry letters.

Benzothiazepinecarboxamides: Novel hepatitis C virus inhibitors that interfere with viral entry and the generation of infectious virions.

Hee-Young Kim, Rita Song, Yoonae Ko, 2016, Antiviral research.

A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology.

H. Jeong, Chi-Hoon Park, Sang-Un Choi, 2020, ACS synthetic biology.

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis.

M. Connelly, David C. Smithson, Fangyi Zhu, 2010, Bioorganic & medicinal chemistry letters.

Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras.

Sunjoo Ahn, H. S. Kim, Seung-Hyun Jo, 2020, European journal of medicinal chemistry.

R. Guy, G. Neale, Prabodh Sadana, 2011, ACS chemical biology.

Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.

Chi-Hoon Park, Joo-Youn Lee, J. Ha, 2017, Bioorganic & medicinal chemistry letters.

Lewis acid-mediated cross-coupling reaction of 7-azaindoles and aldehydes: Cytotoxic evaluation of C3-linked bis-7-azaindoles

N. Mishra, Hyung Sik Kim, Prasanta Dey, 2019, Tetrahedron Letters.

Structure-activity relationship analysis of novel GSPT1 degraders based on benzotriazinone scaffold and its antitumor effect on xenograft mouse model.

Chi-Hoon Park, Jeong-Hoon Kim, Hye Jin Nam, 2022, Bioorganic chemistry.

Synthesis and evaluation of 7-substituted 4-aminoquinoline analogs for antimalarial activity

J. Derisi, R. Guy, David J Lowes, 2013 .

A novel cereblon modulator for targeted protein degradation.

Sung Goo Park, Sunhong Kim, B. Park, 2019, European journal of medicinal chemistry.

Design and Synthesis of Novel Pyrazolo[3,4‐d]pyrimidin‐1‐yl piperidine Derivatives as Bruton's Tyrosine Kinase Inhibitors

Jeong Hee Jeon, Chi-Hoon Park, H. Jung, 2017 .

Novel Inhibitors of Prolyl 4-Hydroxylase; Solid-phase Synthesis of 2,2-Dimethyl-3,4-Dialkoxy-Substituted 6-Aminobenzopyran Derivatives

M. Dong, Young-Baik Cho, Jin-soo Seo, 2006 .

Characterization and structure-activity relationship study of iminodipyridinopyrimidines as novel hepatitis C virus inhibitor.

Hee-Young Kim, Sujin Ahn, M. Windisch, 2017, European journal of medicinal chemistry.

Synthesis and Molecular Modeling Studies of N′-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Sunjoo Ahn, Chang Hoon Lee, Jieun K. Jeong, 2017, Molecules.

Solid-phase synthesis of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives

Y. Gong, J. Hwang, Hyung-Sub Choi, 2005 .

Succinct Syntheses of Methopholine, (±)‐Homolaudanosine, and (±)‐Dysoxyline via Metal‐free One‐Pot Double Alkylation on 1‐Methyl‐3,4‐dihydroisoquinolines

J. Hwang, P. Kim, Gangadhar Rao Mathi, 2019, Bulletin of the Korean Chemical Society.

Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols.

J. Hwang, P. Kim, Gangadhar Rao Mathi, 2018, Organic & biomolecular chemistry.

Design and Synthesis of Novel 3-(2-Aminopyridin-3-yl)-1,2,4-Triazolo[4,3-b ]Pyridazine Derivatives as a Reversible Bruton's Tyrosine Kinase Inhibitors

Jeong Hee Jeon, Chi-Hoon Park, H. Jung, 2018, Bulletin of the Korean Chemical Society.

Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors

Byung Jin Byun, Eun-Young Kim, Chi-Hoon Park, 2016, Archives of pharmacal research.

Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action.

Hee-Young Kim, Sujin Ahn, Z. No, 2014, European journal of medicinal chemistry.

Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor.

Chi-Hoon Park, C. Yun, H. Kim, 2017, Bioorganic & Medicinal Chemistry Letters.

Solid-phase synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via selective, reagent-based cyclization of acyldithiocarbazate resins.

Y. Gong, D. Lee, J. Hwang, 2005, Journal of combinatorial chemistry.

Solid-phase synthesis of the 2-aminobenzoxazole library using thioether linkage as the safety-catch linker.

Y. Gong, J. Hwang, 2006, Journal of combinatorial chemistry.

Solid-phase synthesis of 5-amino-1-(substituted thiocarbamoyl)pyrazole and 1,2,4-triazole derivatives via dithiocarbazate linker.

S. Yoo, Y. Gong, D. Lee, 2005, Journal of combinatorial chemistry.

Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.

V. Setola, B. Roth, R. Guy, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.

J. Cechetto, Inhee Choi, Eunjung Park, 2013, European journal of medicinal chemistry.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.

J. Cechetto, Hee-Young Kim, Junwon Kim, 2012, Bioorganic & medicinal chemistry letters.

Construction of 6-amino-2,2-dimethyl-3,4,6-trisubstituted-2H-1-benzopyran library by solid phase synthesis.

Ji Yeon Park, Jin-soo Seo, S. Yoo, 2003, Journal of combinatorial chemistry.

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

R. Guy, M. Connelly, R. Brun, 2013, Journal of medicinal chemistry.

Efficient and rapid synthesis of N-substituted isoquinolin-1-ones under mild conditions: Facile access to doryanine derivatives

H. Kim, J. Hwang, Akshay. D. Takwale, 2019, Tetrahedron Letters.

Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors

Chi-Hoon Park, H. Jung, C. Yun, 2016, Archives of Pharmacal Research.

Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC).

Chi-Hoon Park, J. Hwang, Jae Du Ha, 2018, Biochemical and biophysical research communications.

Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors.

Eun-Young Kim, Chi-Hoon Park, H. Jung, 2014, Bioorganic & medicinal chemistry letters.

Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Jonghwan Kim, Sung Goo Park, Sunhong Kim, 2020, Cancers.

Discovery of a Novel 2,6-Difunctionalized 2H-Benzopyran Inhibitors Toward Sphingosylphosphorylcholine Synthetic Pathway as New Anti-inflammatory Target

Y. Gong, W. Park, Heeyeong Cho, 2014 .

Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera

D. Hwang, Sunhong Kim, B. Park, 2019, Scientific Reports.

Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins.

H. Jeong, Chi-Hoon Park, H. Jung, 2015, Biochemical and biophysical research communications.

Design and Synthesis of Novel 2,4-Diamino-5-pyrazol-4-yl Pyrimidine Derivatives as Selective Tyro3 Kinase Inhibitors

Chang Hoon Lee, Joo-Youn Lee, S. Cho, 2018, Bulletin of the Korean Chemical Society.

Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer.

H. Jeong, Eun-Young Kim, Sunjoo Ahn, 2016, Cancer letters.

A Quantitative High-Throughput Screen Identifies Novel Inhibitors of the Interaction of Thyroid Receptor β with a Peptide of Steroid Receptor Coactivator 2

Ruili Huang, C. Austin, James Inglese, 2011, Journal of biomolecular screening.

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.

M. Connelly, R. Brun, M. Kaiser, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.

R. Guy, M. Connelly, A. Carrillo, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.

R. Guy, M. Connelly, Fangyi Zhu, 2012, Journal of medicinal chemistry.

Methylsulfonylnitrobenzoates, a New Class of Irreversible Inhibitors of the Interaction of the Thyroid Hormone Receptor and Its Obligate Coactivators That Functionally Antagonizes Thyroid Hormone*

Ruili Huang, C. Austin, James Inglese, 2011, The Journal of Biological Chemistry.

Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.

Sunjoo Ahn, Chi-Hoon Park, H. Jung, 2017, European journal of medicinal chemistry.

Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.

J. Cechetto, Sung-jun Han, Inhee Choi, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors.

J. Cechetto, Sung-jun Han, Inhee Choi, 2013, Bioorganic & medicinal chemistry letters.

Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies.

Sunjoo Ahn, Chi-Hoon Park, Minji Lee, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor.

Sunjoo Ahn, Chi-Hoon Park, Minji Lee, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.

J. Derisi, R. Guy, David J Lowes, 2011, Journal of medicinal chemistry.

Design and Synthesis of 5‐Aryl ‐substituted Phenylpyrimidine‐2,4‐diamine Derivatives as Novel Mer and Tyro3 Kinase Inhibitors

D. Ryu, Joo-Youn Lee, S. Cho, 2020, Bulletin of the Korean Chemical Society.

Design, Synthesis, and Evaluation of 2,4‐Di(piperidine‐substituted‐anilino)pyrimidine Derivatives as ALK Inhibitors

Sunjoo Ahn, Chi-Hoon Park, H. Jung, 2015 .

Cereblon contributes to cardiac dysfunction by degrading Cav1.2α.

Jin Han, T. Minamino, B. Rhee, 2022, European heart journal.

Identification of a series of 1,3,4-trisubstituted pyrazoles as novel hepatitis C virus entry inhibitors.

Inhee Choi, Jinhwa Lee, M. Windisch, 2013, Bioorganic & medicinal chemistry letters.

Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.

Joo Yun Lee, Sunjoo Ahn, H. Jung, 2016, Bioorganic & medicinal chemistry.