T. Kikuchi

发表

Attempts to Image MRP1 Function in the Blood-Brain Barrier Using the Metabolite Extrusion Method

Ming-Rong Zhang, T. Okamura, T. Kikuchi, 2020 .

OAT3-Mediated Extrusion of the 99mTc-ECD Metabolite in the Mouse Brain

Atsushi B. Tsuji, Ming-Rong Zhang, Joji Yui, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

A radiotracer method to study efflux transport of iodide liberated from thyroid hormones via deiodination metabolism in the brain.

K. Fukushi, T. Irie, Y. Arano, 2009, Life sciences.

Reactivity of 6-halopurine analogs with glutathione as a radiotracer for assessing function of multidrug resistance-associated protein 1.

K. Fukushi, T. Irie, T. Okamura, 2009, Journal of medicinal chemistry.

6-[124I]Iodo-9-pentylpurine for imaging the activity of the sodium iodide symporter in the brain.

Atsushi B. Tsuji, Ming-Rong Zhang, H. Ishii, 2020, Journal of medicinal chemistry.

Development of Purine-Derived 18F-Labeled Pro-drug Tracers for Imaging of MRP1 Activity with PET

M. Lythgoe, Ming-Rong Zhang, M. Koepp, 2014, Journal of medicinal chemistry.

Noninvasive and Quantitative Assessment of the Function of Multidrug Resistance-Associated Protein 1 in the Living Brain

K. Fukushi, T. Irie, M. Takei, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Non-input analysis for incomplete trapping irreversible tracer with PET.

Ming-Rong Zhang, T. Irie, T. Fukumura, 2013, Nuclear medicine and biology.

An approach for measuring in vivo cerebral redox states using the oxidative conversion of dihydropyridine to pyridinium ion and the metabolic trapping principle.

K. Fukushi, T. Irie, Y. Arano, 2005, Free radical biology & medicine.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

Imaging of activity of multidrug resistance-associated protein 1 in the lungs.

Ming-Rong Zhang, H. Wakizaka, Maki Okada, 2013, American journal of respiratory cell and molecular biology.

N-[18F]fluoroethyl-4-piperidyl acetate ([18F]FEtP4A): A PET tracer for imaging brain acetylcholinesterase in vivo.

Ming-Rong Zhang, Kazutoshi Suzuki, T. Okauchi, 2003, Bioorganic & medicinal chemistry.

A 11C-Labeled 1,4-Dihydroquinoline Derivative as a Potential PET Tracer for Imaging of Redox Status in Mouse Brain

Ming-Rong Zhang, H. Wakizaka, Maki Okada, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography.

Ming-Rong Zhang, Kenji Furutsuka, N. Nengaki, 2011, Bioorganic & medicinal chemistry.

The use of tetrabutylammonium fluoride to promote N- and O-(11) C-methylation reactions with iodo[(11) C]methane in dimethyl sulfoxide.

Ming-Rong Zhang, Koichi Kato, Hiroki Hashimoto, 2013, Journal of labelled compounds & radiopharmaceuticals.

Tetrabutylammonium fluoride-promoted α-[11C]methylation of α-arylesters: a simple and robust method for the preparation of 11C-labeled ibuprofen

Ming-Rong Zhang, N. Nengaki, T. Arai, 2010 .

PET imaging of MRP1 function in the living brain: method development and future perspectives.

T. Irie, T. Okamura, T. Kikuchi, 2010, Current topics in medicinal chemistry.

Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [11C]DFMC

Ming-Rong Zhang, Tomoteru Yamasaki, Masayuki Fujinaga, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Synthesis of piperidinyl and pyrrolidinyl butyrates for potential In Vivo measurement of cerebral butyrylcholinesterase activity

K. Fukushi, T. Irie, Y. Arano, 2001 .

PET probes for imaging brain acetylcholinesterase.

Ming-Rong Zhang, T. Irie, T. Okamura, 2013, Journal of labelled compounds & radiopharmaceuticals.

N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography.

Ming-Rong Zhang, Kazutoshi Suzuki, K. Fukushi, 2004, Bioorganic & medicinal chemistry letters.

Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography.

Ming-Rong Zhang, H. Wakizaka, Maki Okada, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity.

Ming-Rong Zhang, Kazutoshi Suzuki, K. Fukushi, 2005, Journal of medicinal chemistry.

Rapid ‘on-column’ preparation of hydrogen [11C]cyanide from [11C]methyl iodide via [11C]formaldehyde

Ming-Rong Zhang, A. Gee, Masanao Ogawa, 2022, Chemical science.

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Virginia M. Y. Lee, J. Trojanowski, M. Shigeta, 2020, Neuron.

A novel noninvasive method for assessing glutathione-conjugate efflux systems in the brain.

K. Fukushi, T. Irie, Y. Arano, 2007, Bioorganic & medicinal chemistry.

11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain.

Ming-Rong Zhang, Satoshi Tsukamoto, N. Nengaki, 2022, Bioconjugate chemistry.

Effects of halogenation on tyrosine phosphorylation and peptide binding to the SRC homology 2 domain of lymphocyte-specific protein tyrosine kinase.

K. Fukushi, T. Irie, K. Odaka, 2012, Biological & pharmaceutical bulletin.

Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid

Ming-Rong Zhang, T. Saga, Y. Arano, 2014, The Journal of Nuclear Medicine.

Cerebral acetylcholinesterase imaging: development of the radioprobes.

Ming-Rong Zhang, K. Fukushi, T. Irie, 2007, Current topics in medicinal chemistry.

Estimation of Plasma IC50 of Donepezil for Cerebral Acetylcholinesterase Inhibition in Patients With Alzheimer Disease Using Positron Emission Tomography

T. Suhara, H. Arai, K. Fukushi, 2010, Clinical neuropharmacology.

In vivo evaluation of N‐[18F]fluoroethylpiperidin‐4ylmethyl acetate in rats compared with MP4A as a probe for measuring cerebral acetylcholinesterase activity

Ming-Rong Zhang, K. Fukushi, T. Irie, 2010, Synapse.

Acetate in Rats Compared With MP 4 A as a Probe for Measuring Cerebral Acetylcholinesterase Activity

Ming-Rong Zhang, K. Fukushi, T. Irie, 2009 .

A method to predict the ratio of the tracer conversion rate to the tracer back-diffusion rate of an irreversible-type radiotracer in humans by preclinical evaluations

Ming-Rong Zhang, K. Fukushi, T. Irie, 2012, Nuclear medicine communications.

Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers

Tomoyuki Ohya, Yuji Nagai, Tatsuya Kikuchi, 2011, NeuroImage.

Estimation of Plasma IC50 of Donepezil Hydrochloride for Brain Acetylcholinesterase Inhibition in Monkey Using N-[11C]methylpiperidin-4-yl Acetate ([11C]MP4A) and PET

M. Iyo, S. Tanada, K. Fukushi, 2005, Neuropsychopharmacology.

Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer [11C]DFMC

Ming-Rong Zhang, Tomoteru Yamasaki, Masayuki Fujinaga, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Radiopharmaceutical tracers for cardiac imaging

Ming-Rong Zhang, R. Nishii, A. Scholte, 2017, Journal of Nuclear Cardiology.

A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7

M. Ichise, K. Matsuoka, M. Higuchi, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains

T. Suhara, T. Minamimoto, J. Maeda, 2021, The EMBO journal.

Genetically targeted reporter imaging of deep neuronal network in the mammalian brain

T. Suhara, T. Minamimoto, J. Maeda, 2020, bioRxiv.

Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples

T. Obata, K. Fukushi, T. Irie, 2010, British journal of pharmacology.

Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay.

K. Fukushi, T. Irie, T. Okamura, 2010, Biological & pharmaceutical bulletin.

In-vivo imaging of blood–brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid

I. Aoki, Y. Ikoma, T. Kamakura, 2015, Nuclear medicine communications.

Therapeutic Efficacy of C-Kit-Targeted Radioimmunotherapy Using 90Y-Labeled Anti-C-Kit Antibodies in a Mouse Model of Small Cell Lung Cancer

Atsushi B. Tsuji, T. Saga, M. Koizumi, 2013, PloS one.

Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.

T. Saga, Y. Arano, A. Tsuji, 2013, Bioorganic & medicinal chemistry letters.

Benzyl [(11)C]Hippurate as an Agent for Measuring the Activities of Organic Anion Transporter 3 in the Brain and Multidrug Resistance-Associated Protein 4 in the Heart of Mice.

A. Gee, Joji Yui, T. Fukumura, 2016, Journal of medicinal chemistry.

Improvement of brain uptake for in vivo PET imaging of astrocytic oxidative metabolism using benzyl [1-(11)C]acetate.

O. Inoue, R. Nakao, H. Wakizaka, 2013, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases

Ming-Rong Zhang, A. Kakita, M. Ichise, 2020, bioRxiv.

In vivo visualization of propagating α -synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05

A. Kakita, T. Minamimoto, Yuji Nagai, 2021 .

Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course

H. Wakizaka, Maki Okada, T. Okamura, 2018, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Development of an In Vivo Method to Estimate Effective Drug Doses and Quantify Fatty Acid Amide Hydrolase in Rodent Brain using Positron Emission Tomography Tracer N-(3,4-dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[11C]methylphenyl)thiazol-2-yl]-1-carboxamide ([11C]DFMC)

N. Nengaki, T. Kikuchi, Hidekatsu, 2020 .