P. Bialek

发表

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

James R. Apgar, K. Parris, K. Svenson, 2016, mAbs.

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

M. Elsalanty, S. Upadhyay, L. Liang, 2013, Experimental Gerontology.

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Mark Johnson, P. Bansal, A. Robertson, 2017, Skeletal Muscle.

Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction.

J. Khosravi, V. Han, C. Watson, 2006, Endocrinology.

Distinct protein degradation profiles are induced by different disuse models of skeletal muscle atrophy.

H. Seeherman, S. Jelinsky, P. Yaworsky, 2011, Physiological genomics.

Distinct Protein Degradation Profiles Are Induced by Different Disuse Models of 1 Skeletal Muscle Atrophy 2 Running Title: Distinct Protein Degradation Pathways in Muscle Atrophy

H. Seeherman, S. Jelinsky, P. Yaworsky, 2011 .

Mice treated with a myostatin/GDF-8 decoy receptor, ActRIIB-Fc, exhibit a tremendous increase in bone mass

H. Seeherman, Liang Jian, P. Yaworsky, 2008 .

Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.

R. Behringer, G. Karsenty, E. Hinoi, 2006, Genes & development.

A Novel Role for Twist-1 in Pulp Homeostasis

G. Karsenty, K. Galler, R. D'Souza, 2007, Journal of dental research.

Strategies for skeletal muscle targeting in drug discovery.

A. El‐Kattan, M. Tu, C. Ambler, 2015, Current pharmaceutical design.

Characterization of a novel insertional mouse mutation, kkt: A closely linked modifier of Pax1.

C. Chan, S. Yee, P. Bialek, 2000, Developmental biology.

ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology Implication for Coffin-Lowry Syndrome

P. Sassone-Corsi, G. Karsenty, A. Hanauer, 2004, Cell.

A twist code determines the onset of osteoblast differentiation.

M. Justice, E. Olson, G. Karsenty, 2004, Developmental cell.

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Hans Clevers, Andrew P McMahon, Michael Starbuck, 2005, Developmental cell.

Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice.

G. F. Wagner, S. Yee, P. Bialek, 2002, Endocrinology.

Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy

B. Mandefro, Brian E. Schwartz, J. Barsoum, 2017, Proceedings of the National Academy of Sciences.

A myostatin and activin decoy receptor enhances bone formation in mice.

H. Seeherman, P. Yaworsky, X. Li, 2014, Bone.

A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys

Mark Johnson, P. Bansal, A. Robertson, 2017, Skeletal Muscle.