K. Trouba

发表

Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum.

Jim X. Shen, B. Desilva, R. Pillutla, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.

Bonnie Wang, M. Arnold, Jian Wang, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017)

M. Wright, R. Schulingkamp, Donna W. Lee, 2019, Toxicologic pathology.

Compensatory modulation of GAP activity in response to oncogenic stimulation.

L. Liao, R. L. Vorce, K. Trouba, 1996, Cancer letters.

Biokinetics and Subchronic Toxic Effects of Oral Arsenite, Arsenate, Monomethylarsonic Acid, and Dimethylarsinic Acid in v-Ha-ras Transgenic (Tg.AC) Mice

Jie Liu, M. Waalkes, D. Germolec, 2004, Environmental health perspectives.

Effect of antioxidants on the papilloma response and liver glutathione modulation mediated by arsenic in Tg.AC transgenic mice

D. Dunson, D. Germolec, A. Nyska, 2003 .

In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2′-C-Methylguanosine Prodrug BMS-986094

W. Humphreys, O. Flint, M. Davies, 2017, International journal of toxicology.

Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes.

D. Germolec, K. Trouba, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.

D. Germolec, K. Trouba, Kristen Geisenhoffer, 2002, Environmental health perspectives.

Sodium arsenite inhibits terminal differentiation of murine C3H 10T1/2 preadipocytes.

E. Wauson, R. L. Vorce, K. Trouba, 2000, Toxicology and applied pharmacology.

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.

Valérie Zuang, Sebastian Hoffmann, Thomas Hartung, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Oxidative stress and its role in skin disease.

H. Hamadeh, Rupesh P. Amin, D. Germolec, 2002, Antioxidants & redox signaling.

Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes.

C. Afshari, H. Hamadeh, Rupesh P. Amin, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling.

E. Wauson, R. L. Vorce, K. Trouba, 2000, Toxicology and applied pharmacology.

Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure.

J. Glanzer, R. L. Vorce, K. Trouba, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Determinants of species- and placenta-specific expression of p100 GAP.

L. Liao, R. L. Vorce, K. Trouba, 1998, Placenta.

Discovery and pharmacological characterization of cetrelimab (JNJ-63723283), an anti–programmed cell death protein-1 (PD-1) antibody, in human cancer models

Rupesh K. Nanjunda, K. Packman, G. Powers, 2022, Cancer Chemotherapy and Pharmacology.

Arsenic-induced alterations in the contact hypersensitivity response in Balb/c mice.

C. Bortner, D. Germolec, R. Patterson, 2004, Toxicology and applied pharmacology.

Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

Naiyu Zheng, Jianing Zeng, Mark E Arnold, 2014, Journal of pharmaceutical and biomedical analysis.

The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.

M. Leach, P. van Meer, L. de Haan, 2023, Regulatory toxicology and pharmacology : RTP.

Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.

M. Leach, P. van Meer, L. de Haan, 2022, Regulatory toxicology and pharmacology : RTP.

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

Naiyu Zheng, Jianing Zeng, Yuan-Qing Xia, 2013, Journal of pharmaceutical and biomedical analysis.

Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies.

B. McIntyre, E. Thackaberry, K. Trouba, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.

M. Leach, P. van Meer, L. de Haan, 2022, Regulatory toxicology and pharmacology : RTP.

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.

W. Stokes, T. Hartung, H. Kamp, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2′-C-Methylguanosine Prodrug BMS-986094

W. Humphreys, O. Flint, M. Davies, 2017, International journal of toxicology.