C. Haan

发表

The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

V. Satagopam, T. Sauter, S. Haan, 2015, JAK-STAT.

SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling

I. Behrmann, S. Haan, S. Wüller, 2009, Oncogene.

An Unusual Insertion in Jak2 Is Crucial for Kinase Activity and Differentially Affects Cytokine Responses

P. Heinrich, I. Behrmann, S. Haan, 2009, The Journal of Immunology.

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.

S. Feller, I. Behrmann, F. Schaper, 2017, Cellular signalling.

Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells

I. Behrmann, C. Haan, A. Zimmer, 2016, Hypoxia.

Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8 chemokine expression

J. Tuckermann, C. Hintzen, C. Haan, 2009, Cell Communication and Signaling.

Oncostatin M-Induced and Constitutive Activation of the JAK2/STAT5/CIS Pathway Suppresses CCL1, but Not CCL7 and CCL8, Chemokine Expression1

P. Heinrich, H. Hermanns, J. Tuckermann, 2008, The Journal of Immunology.

CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells

F. Thorsen, T. Sundstrøm, C. Haan, 2022, PloS one.

Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.

Serge Haan, P. Heinrich, I. Behrmann, 2005, Cellular signalling.

Mapping of a Region within the N Terminus of Jak1 Involved in Cytokine Receptor Interaction*

I. Kerr, P. Heinrich, I. Behrmann, 2001, The Journal of Biological Chemistry.

The Jak1 SH2 Domain Does Not Fulfill a Classical SH2 Function in Jak/STAT Signaling but Plays a Structural Role for Receptor Interaction and Up-regulation of Receptor Surface Expression*

P. Heinrich, I. Behrmann, S. Haan, 2005, Journal of Biological Chemistry.

A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background.

I. Behrmann, C. Haan, 2007, Journal of immunological methods.

Many ways to resistance: How melanoma cells evade targeted therapies.

S. Kreis, C. Margue, C. Haan, 2019, Biochimica et biophysica acta. Reviews on cancer.

Interleukin‐27 displays interferon‐γ–like functions in human hepatoma cells and hepatocytes

P. Heinrich, S. Haan, N. Kato, 2009, Hepatology.

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

I. Petersen, L. Kenner, R. Moriggl, 2014, Oncotarget.

Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3

I. Behrmann, S. Rose-John, M. Hamdorf, 2019, Molecular therapy. Nucleic acids.

A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.

P. Heinrich, I. Behrmann, H. Hermanns, 2000, The Biochemical journal.

Jaks and cytokine receptors--an intimate relationship.

Stephanie Kreis, I. Behrmann, S. Kreis, 2006, Biochemical pharmacology.

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F

I. Behrmann, G. Berchem, R. Eulenfeld, 2013, Journal of cellular and molecular medicine.

JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

I. Behrmann, C. Haan, Karoline Gäbler, 2013, JAK-STAT.

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

I. Behrmann, S. Haan, C. Haan, 2010, Journal of cellular and molecular medicine.

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

I. Behrmann, S. Haan, F. Schaper, 2013, JAK-STAT.

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.

I. Behrmann, G. Thoma, H. Zerwes, 2011, Chemistry & biology.

Cytokine Responses Kinase Activity and Differentially Affects An Unusual Insertion in Jak 2 Is Crucial for

P. Heinrich, I. Behrmann, S. Haan, 2009 .

Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.

S. Haan, C. Haan, 2013, Methods in molecular biology.

Janus Kinase (Jak) Subcellular Localization Revisited

P. Heinrich, I. Behrmann, S. Haan, 2004, Journal of Biological Chemistry.

Recombinant Interleukin-24 Lacks Apoptosis-Inducing Properties in Melanoma Cells

J. Renauld, I. Behrmann, D. Philippidou, 2007, PloS one.

Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Dagmar Kulms, Stephanie Kreis, D. Philippidou, 2019, Journal of Experimental & Clinical Cancer Research.

Termination of IL‐6‐induced STAT activation is independent of receptor internalization but requires de novo protein synthesis

P. Heinrich, I. Behrmann, U. Sommer, 2000, FEBS letters.

A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

François Bernardin, D. Philippidou, A. Wienecke-Baldacchino, 2018, Molecular Cancer.

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.

J. Tavernier, P. Heinrich, I. Behrmann, 1999, Journal of immunology.

Complexes with Glycoprotein 130 Signal Transduction in Heterodimeric Receptor and Oncostatin M Receptor to Contributions of Leukemia Inhibitory Factor

J. Tavernier, P. Heinrich, I. Behrmann, 1999 .

Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells.

I. Behrmann, C. Haan, S. Vollmer, 2010, Biochemical pharmacology.

Hypoxia‐inducible factor 1α is up‐regulated by oncostatin M and participates in oncostatin M signaling

I. Behrmann, N. Kato, T. Kietzmann, 2009, Hepatology.

Regulation of JAKs: Insights gleaned from the functional protein domains

S. Haan, O. Silvennoinen, D. Ungureanu, 2012 .

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

S. Kreis, C. Haan, G. Cesi, 2017, Molecular Cancer.

The PD‐L1‐ and IL6‐mediated dampening of the IL27/STAT1 anticancer responses are prevented by α‐PD‐L1 or α‐IL6 antibodies

A. Ginolhac, I. Behrmann, S. Haan, 2018, Journal of leukocyte biology.

Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types.

A. Ginolhac, I. Behrmann, P. Nazarov, 2020, Journal of molecular biology.

Oncostatin M induces RIG‐I and MDA5 expression and enhances the double‐stranded RNA response in fibroblasts

H. Hermanns, C. Mais, A. Costa-Pereira, 2017, Journal of cellular and molecular medicine.

Long Term Association of the Cytokine Receptor gp130 and the Janus Kinase Jak1 Revealed by FRAP Analysis*

Bernd Giese, Andreas Herrmann, Peter C. Heinrich, 2003, Journal of Biological Chemistry.

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.

P. Heinrich, I. Behrmann, C. Haan, 2002, The Biochemical journal.

Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.

S. Haan, C. Haan, 2013, Methods in molecular biology.

Novel Role of Janus Kinase 1 in the Regulation of Oncostatin M Receptor Surface Expression*

P. Heinrich, I. Behrmann, H. Hermanns, 2002, The Journal of Biological Chemistry.

Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines.

A. Ginolhac, I. Behrmann, S. Haan, 2017, Biochimica et biophysica acta. Molecular cell research.

The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells

N. Battello, I. Behrmann, K. Hiller, 2016, Cancer & metabolism.

Dual Role of the Jak1 FERM and Kinase Domains in Cytokine Receptor Binding and in Stimulation-Dependent Jak Activation1

P. Heinrich, I. Behrmann, S. Haan, 2008, The Journal of Immunology.