F. Esposito

发表

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

L. Mayol, A. Pepe, E. Tramontano, 2020, International journal of molecular sciences.

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

Lijia Xu, D. Piano, C. Del Vecchio, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Past and Future. Current Drugs Targeting HIV-1 Integrase and Reverse Transcriptase-Associated Ribonuclease H Activity: Single and Dual Active Site Inhibitors

E. Tramontano, F. Esposito, 2014, Antiviral chemistry & chemotherapy.

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

M. Scognamiglio, A. Fiorentino, E. Tramontano, 2018, PloS one.

Design, Synthesis, and Biological Evaluation of 1,3‐Diarylpropenones as Dual Inhibitors of HIV‐1 Reverse Transcriptase

M. Fresta, E. Tramontano, S. Alcaro, 2014, ChemMedChem.

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

Lijia Xu, D. Piano, C. Del Vecchio, 2015, Journal of Microbiology.

Natural Compounds Inhibit SARS-CoV-2 nsp13 Unwinding and ATPase Enzyme Activities

Daniela Iaconis, V. Summa, M. Nowotny, 2022, ACS pharmacology & translational science.

Target Therapy in Thyroid Cancer: Current Challenge in Clinical Use of Tyrosine Kinase Inhibitors and Management of Side Effects

D. Giuffrida, S. Marchisotta, F. Esposito, 2022, Frontiers in Endocrinology.

Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy

R. Giuffrida, S. Forte, F. Esposito, 2021, International journal of molecular sciences.

HILIC-UPLC-MS for high throughput and isomeric N-glycan separation and characterization in Congenital Disorders Glycosylation and human diseases

A. Messina, J. Jaeken, L. Sturiale, 2020, Glycoconjugate Journal.

ALG12-CDG: novel glycophenotype insights endorse the molecular defect

S. Bianca, A. Messina, E. Agolini, 2019, Glycoconjugate Journal.

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

C. Pannecouque, L. Naesens, M. Carcelli, 2017, Front. Microbiol..

Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.

E. Novellino, S. Di Maro, R. Di Santo, 2020, ACS Medicinal Chemistry Letters.

Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

J. Blomberg, Nicole Grandi, E. Tramontano, 2017, Mobile DNA.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, V. Summa, 2020, bioRxiv.

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

J. Neyts, D. Schols, E. Tramontano, 2022, ACS medicinal chemistry letters.

dsRNA binding characterization of full length recombinant wild type and mutants Zaire ebolavirus VP35

D. Pala, E. Tramontano, L. Zinzula, 2011, Antiviral Research.

Purification and functional characterization of the full length recombinant Ebola virus VP35 protein expressed in E. coli.

D. Piano, E. Mühlberger, E. Tramontano, 2009, Protein expression and purification.

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

E. Ballana, R. Badia, J. Esté, 2020, Viruses.

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.

Y. Pommier, R. Di Santo, R. Costi, 2015, Journal of medicinal chemistry.

Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route

M. Brindisi, V. Summa, P. Storici, 2022, European Journal of Medicinal Chemistry.

The use of a new in vitro reaction substrate reproducing both U3 and U5 regions of the HIV-1 3'-ends increases the correlation between the in vitro and in vivo effects of the HIV-1 integrase inhibitors.

P. la Colla, E. Tramontano, R. Badas, 2004, Biochemical pharmacology.

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

C. Collard, Daniela Iaconis, V. Summa, 2022, Scientific data.

HIV-1-inhibiting activity of the essential oil of Ridolfia segetum and Oenanthe crocata.

E. Tramontano, C. Bicchi, L. Zinzula, 2009, Planta medica.

Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds

E. Tramontano, L. Zinzula, A. Maxia, 2011, Natural product research.

ZnO-mediated regioselective C-arylsulfonylation of indoles: a facile solvent-free synthesis of 2- and 3-sulfonylindoles and preliminary evaluation of their activity against drug-resistant mutant HIV-1 reverse transcriptases (RTs)

P. Caboni, E. Tramontano, M. Begala, 2013 .

6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro.

R. Di Santo, R. Costi, P. la Colla, 2005, Antiviral research.

Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity.

E. Tramontano, A. Geronikaki, P. Eleftheriou, 2019, European journal of medicinal chemistry.

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

E. Novellino, O. Delelis, R. Di Santo, 2014, Antimicrobial Agents and Chemotherapy.

New insights into the operative network of FaEO, an enone oxidoreductase from Fragaria x ananassa Duch.

Joanna M. Kirkpatrick, D. Piano, F. Pintus, 2017, Plant Molecular Biology.

Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action.

D. Piano, C. Del Vecchio, E. Tramontano, 2017, Pathogens and disease.

Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

C. Del Vecchio, E. Tramontano, C. Parolin, 2013, Pathogens and disease.

Biological Activities of Aerial Parts Extracts of Euphorbia characias

R. Medda, F. Pintus, E. Tramontano, 2016, BioMed research international.

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

E. Novellino, R. Di Santo, R. Costi, 2021, Journal of medicinal chemistry.

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

P. Mátyus, D. Secci, E. Tramontano, 2021, Molecules.

2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

C. Del Vecchio, E. Tramontano, V. Onnis, 2020, Molecules.

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

P. Caboni, S. L. Le Grice, J. Beutler, 2020, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions

E. Tramontano, S. Alcaro, S. Distinto, 2017, Pathogens and disease.

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.

E. Novellino, O. Delelis, R. Di Santo, 2016, Antiviral research.

Studies on Cycloheptathiophene‐3‐carboxamide Derivatives as Allosteric HIV‐1 Ribonuclease H Inhibitors

C. Pannecouque, E. Tramontano, S. Sabatini, 2016, ChemMedChem.

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

S. L. Le Grice, L. Menéndez-Arias, E. Tramontano, 2016, PloS one.

(3Z)-3-(2-[4-(aryl)-1,3-thiazol-2-yl]hydrazin-1-ylidene)-2,3-dihydro-1H-indol-2-one derivatives as dual inhibitors of HIV-1 reverse transcriptase.

P. Mátyus, E. Tramontano, S. Alcaro, 2015, European journal of medicinal chemistry.

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.

Y. Pommier, E. Novellino, R. Di Santo, 2013, Journal of medicinal chemistry.

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.

Stefano Alcaro, Francesca Esposito, Gerhard Wolber, 2012, European journal of medicinal chemistry.

Alizarine derivatives as new dual inhibitors of the HIV‐1 reverse transcriptase‐associated DNA polymerase and RNase H activities effective also on the RNase H activity of non‐nucleoside resistant reverse transcriptases

P. Markt, E. Tramontano, G. Floris, 2011, The FEBS journal.

Euphorbia characias latex: micromorphology of rubber particles and rubber transferase activity.

R. Medda, F. Pintus, G. Floris, 2015, Plant physiology and biochemistry : PPB.

HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions

E. Tramontano, A. Corona, F. Esposito, 2012, Molecular biology international.

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

C. Tintori, M. Botta, R. Ferrarese, 2017, Chembiochem : a European journal of chemical biology.

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities

L. Naesens, M. Carcelli, D. Rogolino, 2016, International journal of molecular sciences.

New Anthraquinone Derivatives as Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Function

E. Tramontano, L. Zinzula, A. Corona, 2012, Chemotherapy.

Effects of New Quinizarin Derivatives on Both HCV NS5B RNA Polymerase and HIV-1 Reverse Transcriptase Associated Ribonuclease H Activities

E. Tramontano, L. Zinzula, F. Esposito, 2011, Journal of chemotherapy.

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

E. Tramontano, A. Corona, F. Esposito, 2014 .

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Identification of Myricetin as an Ebola Virus VP35-Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.

O. Taglialatela‐Scafati, E. Tramontano, L. Zinzula, 2018, Biochemistry.

Comparison of the Number of IL–4 and IFN–7 Secreting Cells in Response to the Malaria Vaccine Candidate Antigen Pf155/RESA in Two Groups of Naturally Primed Individuals Living in a Malaria Endemic Area in Burkina Faso

M. Troye-Blomberg, G. ELGHAZALI, F. ESPOSITO, 1995, Scandinavian journal of immunology.

Inhibition of HIV‐1 Reverse Transcriptase Dimerization by Small Molecules

C. Tintori, M. Botta, M. Clementi, 2016, Chembiochem : a European journal of chemical biology.

RhVI1 is a membrane-anchored vacuolar invertase highly expressed in Rosa hybrida L. petals

Joanna M. Kirkpatrick, D. Piano, Domenica Farci, 2016, Journal of experimental botany.

Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion

J. Blomberg, Nicole Grandi, E. Tramontano, 2017, Mobile DNA.

The combination of polar body and embryo biopsy does not affect embryo viability.

L. Gianaroli, A. Ferraretti, M. Toschi, 2004, Human reproduction.

Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

G. Rossetti, P. Storici, N. Demitri, 2021, International journal of molecular sciences.

Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice

E. Pariani, R. De Francesco, D. Inverso, 2022, bioRxiv.

Onopordum illyricum L., a Mediterranean plant, as a source of anti HIV-1 compounds

C. Del Vecchio, E. Tramontano, C. Parolin, 2018 .

A Luciferase Reporter Gene Assay to Measure Ebola Virus Viral Protein 35-Associated Inhibition of Double-Stranded RNA-Stimulated, Retinoic Acid-Inducible Gene 1-Mediated Induction of Interferon β.

E. Tramontano, A. Corona, F. Esposito, 2015, The Journal of infectious diseases.

Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity

B. Valentinis, Annalisa Capobianco, P. Rovere-Querini, 2008, Journal of leukocyte biology.

S-layer proteins as a source of carotenoids: Isolation of the carotenoid cofactor deinoxanthin from its S-layer protein DR_2577.

D. Piano, Domenica Farci, F. Esposito, 2017, Food research international.

Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

S. McSweeney, M. Bowler, D. Piano, 2015, Front. Microbiol..

Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis

G. Biamonti, S. Francia, S. Farina, 2021, Frontiers in Molecular Biosciences.

Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)

D. Piano, O. Taglialatela‐Scafati, E. Tramontano, 2019, Natural product research.

Structure-guided approach identifies a novel class of HIV-1 ribonuclease H inhibitors: binding mode insights through magnesium complexation and site-directed mutagenesis studies.

Vasanthanathan Poongavanam, J. Kongsted, R. Di Santo, 2018, MedChemComm.

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, V. Summa, 2021, ACS pharmacology & translational science.

Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata

A. Fiorentino, R. Russo, B. D’Abrosca, 2021, Molecules.

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds

E. Tramontano, P. Rubiolo, A. Corona, 2021, Plants.

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

C. Tintori, M. Botta, F. Morreale, 2015, Bioorganic & medicinal chemistry letters.

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

Lijia Xu, D. Piano, Nicole Grandi, 2015, Journal of Microbiology.

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.

E. Novellino, L. Naesens, R. Di Santo, 2019, Antiviral research.

Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture.

P. Singh, M. Carcelli, E. Tramontano, 2020, ACS medicinal chemistry letters.

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

C. Tintori, M. Botta, Z. Debyser, 2015, Chembiochem : a European journal of chemical biology.

Site directed mutagenesis studies on HIV-1 reverse transcriptase (RT) shed light on the mechanism of action of a new Ribonuclease H/ DNA polymerase RT dual inhibitor

E. Tramontano, E. Maccioni, S. Distinto, 2013, Retrovirology.

Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach

F. Ceccherini‐Silberstein, E. Tramontano, S. Alcaro, 2023, J. Chem. Inf. Model..

Nirmatrelvir treatment of SARS‐CoV‐2‐infected mice blunts antiviral adaptive immune responses

E. Pariani, S. Perlman, R. De Francesco, 2023, EMBO molecular medicine.

5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action

O. Delelis, E. Tramontano, E. Maccioni, 2023, Frontiers in Cellular and Infection Microbiology.

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase

E. Novellino, P. Grieco, A. Bertamino, 2016, Front. Microbiol..

DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

Daniela Iaconis, K. Riecken, E. Tramontano, 2023, Viruses.

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

M. Brindisi, V. Summa, P. Storici, 2023, European Journal of Medicinal Chemistry.

On the S-layer of Thermus thermophilus and the assembling of its main protein SlpA.

Joanna M. Kirkpatrick, D. Piano, E. Tramontano, 2018, Biochimica et biophysica acta. Biomembranes.

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

E. Novellino, I. Gomez-Monterrey, S. Haider, 2018, Scientific Reports.

RhVI1 is a membrane-anchored vacuolar invertase highly expressed in Rosa hybrida L. petals

Joanna M. Kirkpatrick, D. Piano, Domenica Farci, 2016, Journal of experimental botany.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, J. Neyts, 2020 .

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, J. Neyts, 2021, ACS Pharmacology & Translational Science.

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops

E. Novellino, I. Gomez-Monterrey, S. Haider, 2018, Scientific Reports.

Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro.

Lydia Siragusa, F. Spyrakis, C. Prandi, 2023, ACS infectious diseases.

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments.

C. Tintori, M. Botta, F. Morreale, 2015, Bioorganic & medicinal chemistry letters.

HIV-1 Integrase Inhibition Activity by Spiroketals Derived from Plagius flosculosus, an Endemic Plant of Sardinia (Italy) and Corsica (France)

A. Fiorentino, B. D’Abrosca, E. Tramontano, 2023, Pharmaceuticals.

Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex

Daniela Iaconis, E. Tramontano, A. Beccari, 2024, Virus research.

Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169

S. Grdadolnik, J. Plavec, Daniela Iaconis, 2023, bioRxiv.

Natural Product Kuwanon‐L Inhibits HIV‐1 Replication through Multiple Target Binding

C. Tintori, M. Botta, R. Ferrarese, 2017, Chembiochem : a European journal of chemical biology.