T. Hirayama

发表

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.

Terufumi Takagi, H. Oki, Terufumi Takagi, 2013, Bioorganic & medicinal chemistry.

Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.

M. Okaniwa, T. Kawamoto, T. Ishikawa, 2016, Bioorganic & medicinal chemistry letters.

Chemo- and regioselective preparation and reaction of a kinetic zinc enolate formed from a thiol ester and bis(iodozincio)methane.

S. Matsubara, T. Hirayama, Zenichi Ikeda, 2006, Angewandte Chemie.

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential.

Maki Hasegawa, Kazunobu Aoyama, A. Hata, 2017, Bioorganic & medicinal chemistry.

Nucleophilic cyclopropanation reaction with bis(iodozincio)methane by 1,4-addition to alpha,beta-unsaturated carbonyl compounds.

S. Matsubara, T. Hirayama, K. Nomura, 2009, Chemistry, an Asian journal.

Preparation of enolate-homoenolate species as (Z)-gamma-siloxyallylmetal equivalents: sequential 1,4-addition of bis(iodozincio)methane to 1,4-dicarbonylbutenes and cyclopropanation.

K. Oshima, S. Matsubara, T. Hirayama, 2005, Angewandte Chemie.

Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives.

Hiroshi Banno, Yuka Hasegawa, M. Okaniwa, 2017, Bioorganic & medicinal chemistry.

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.

H. Oki, K. Okada, M. Tawada, 2013, Bioorganic & medicinal chemistry.

Preparation of Enolate—Homoenolate Species as (Z)‐γ‐Siloxyallylmetal Equivalents: Sequential 1,4‐Addition of Bis(iodozincio)methane to 1,4‐Dicarbonylbutenes and Cyclopropanation.

K. Oshima, S. Matsubara, T. Hirayama, 2005 .

Nucleophilic Cyclopropanation Reaction with Bis(iodozincio)methane by 1,4‐Addition to α,β‐Unsaturated Carbonyl Compounds.

S. Matsubara, T. Hirayama, K. Nomura, 2009 .

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

K. Iwata, M. Okaniwa, T. Kawamoto, 2015, Nature Communications.

Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.

Hiroshi Banno, Tomoyasu Ishikawa, Akihiro Yokota, 2015, Journal of medicinal chemistry.

SN2 Type Hydrolysis of Secondary Alkyl Halides and Sulfonates in Hydrothermal Water

K. Oshima, S. Matsubara, T. Hirayama, 2004 .

Prolyl-tRNA synthetase inhibition promotes cell death in SK-MEL-2 cells through GCN2-ATF4 pathway activation.

T. Arita, H. Miyashita, T. Hara, 2017, Biochemical and biophysical research communications.

Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.

Tomoyasu Ishikawa, Akihiro Yokota, Akihiro Ohashi, 2013, Bioorganic & medicinal chemistry.