K. Koike

发表

Effects of ageing on nicotine-induced contraction and substance P-like materials release in guinea-pig bronchus.

I. Takayanagi, M. Moriya, R. Kurata, 1991, General pharmacology.

Recent advances in structure, binding sites with ligands and pharmacological function of beta-adrenoceptors obtained by molecular biology and molecular modeling.

K. Koike, T. Nagatomo, 2000, Life sciences.

Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opioid receptor ligand

K. Kanematsu, S. Ozawa, I. Takayanagi, 1995 .

Effect of a calcium sensitization modulator, Y-27632, on isolated human bronchus and pulmonary artery.

K. Shirato, M. Ichinose, A. Koarai, 2000, Pulmonary pharmacology & therapeutics.

Functional contribution of voltage-dependent and Ca2+ activated K+ (BK(Ca)) channels to the relaxation of guinea-pig aorta in response to natriuretic peptides.

K. Shigenobu, Hikaru Tanaka, T. Horinouchi, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

α1‐Adrenoceptors are required for normal male sexual function

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007 .

RESEARCH PAPER a 1 -Adrenoceptors are required for normal male sexual function

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007 .

Pharmacological evaluation of plasma membrane beta-adrenoceptors in rat hearts using the tissue segment binding method.

S. Morishima, T. Horinouchi, Takashi Tanaka, 2006, Life sciences.

Kv Channels Contribute to Nitric Oxide- and Atrial Natriuretic Peptide-Induced Relaxation of a Rat Conduit Artery

E. Stefani, M. Eghbali, Min-Cheol Song, 2006, Journal of Pharmacology and Experimental Therapeutics.

Beta1-adrenoceptor-mediated relaxation with isoprenaline and the role of MaxiK channels in guinea-pig esophageal smooth muscle.

T. Horinouchi, Yoshio Tanaka, K. Koike, 2004, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

MaxiK channel mediates beta2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle.

K. Shigenobu, T. Horinouchi, Yoshio Tanaka, 2003, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing ω-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of rabbit facial vein

K. Shigenobu, Hikaru Tanaka, T. Horinouchi, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

K. Shigenobu, Hikaru Tanaka, T. Horinouchi, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

Y. Yamamoto, Y. Tanaka, H. Tanaka, 2001, Acta physiologica Scandinavica.

Variation in Sensitivity of al-Adrenoceptor Stimulants and ai-Adrenoceptor Mechanisms in Rabbit Arteries

I. Takayanagi, K. Koike, S. Onozuka, 2006 .

Analysis of alpha1-adrenoceptor subtypes in rabbit aorta and arteries: regional difference and co-existence.

K. Enomoto, M. Satoh, I. Takayanagi, 1999, European journal of pharmacology.

Regional differences in alpha1-adrenoceptor subtypes and mechanisms in rabbit arteries.

H. Fujimura, K. Enomoto, M. Satoh, 1998, European journal of pharmacology.

Involvement of beta 3-adrenoceptor in the relaxation response in guinea pig taenia caecum.

M. Muramatsu, T. Horinouchi, S. Ohki, 1994, Japanese journal of pharmacology.

Effects of aging on α2-adrenoceptor mechanisms in isolated guinea-pig tracheal preparations

I. Takayanagi, K. Koike, K. Kawano, 1991 .

Variation in sensitivity of alpha 1-adrenoceptor stimulants and alpha 1-adrenoceptor mechanisms in rabbit arteries.

I. Takayanagi, K. Koike, S. Onozuka, 1991, Japanese journal of pharmacology.

Effect of Aging on the Response of Guinea Pig Trachea to Isoprenaline

I. Takayanagi, K. Koike, K. Kawano, 1990 .

Effect of aging on the response of guinea pig trachea to isoprenaline.

I. Takayanagi, K. Koike, K. Kawano, 1990, Japanese journal of pharmacology.

α2-adrenoceptor mechanisms in guinea-pig trachea

I. Takayanagi, K. Koike, K. Kawano, 1990 .

The selectivity of newly synthesized ergot derivatives to α1- and α2-adrenoceptors, D1- and D2-dopaminergic receptors, muscarinic acetylcholinoceptors and β-adrenoceptors

I. Takayanagi, K. Koike, K. Okumura, 1988 .

Effects of cooling on alpha-1-adrenoceptor mechanisms in rat aorta.

M. Nakamura, I. Takayanagi, K. Koike, 1988, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Characteristics of Ca2+ oscillations in ileal longitudinal muscle cells of guinea pig.

M. Satoh, I. Takayanagi, K. Koike, 2000, Japanese journal of pharmacology.

MaxiK channel-triggered negative feedback system is preserved in the urinary bladder smooth muscle from streptozotocin-induced diabetic rats.

K. Sakamoto, K. Ishii, T. Nakahara, 2004, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

2-Aminoethoxydiphenyl borate causes dissociation between membrane electrical and mechanical activity in guinea-pig urinary bladder smooth muscle

K. Shigenobu, Hikaru Tanaka, T. Horinouchi, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of bupranolol for BRL37344 and noradrenaline-induced relaxations mediating atypical beta/beta3-adrenoceptor in rat oesophageal muscularis mucosae.

T. Horinouchi, K. Koike, H. Koshikawa, 1999, General pharmacology.

Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice.

G. Tsujimoto, A. Tanoue, A. Sanbe, 2009, Life sciences.

Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

Y. Yamamoto, K. Shigenobu, T. Horinouchi, 2002, Acta physiologica Scandinavica.

Beta1-subunit of MaxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity.

E. Stefani, L. Toro, A. Alioua, 2004, Journal of pharmacological sciences.

Functional analysis of guinea pig β1-adrenoceptor

S. Kimura, Y. Kasuya, H. Takahashi, 2011, Journal of receptor and signal transduction research.

Ca-entry blockers, verapamil and diltiazem, on alpha 1-adrenoceptors in thoracic aorta, renal artery and portal vein from rabbit.

K. Kishii, I. Takayanagi, K. Koike, 1988, General pharmacology.

The effects of several vasopressin receptor antagonists on normal intraocular pressure and the intraocular distribution of vasopressin receptor subtypes.

T. Kurasawa, K. Shigenobu, K. Koike, 2002, Biological & pharmaceutical bulletin.

INHIBITORY EFFECTS OF FULLERENE C60 DERIVATIVES ON ENDOTHELIUM-DERIVED RELAXATION IN RABBIT THORACIC AORTA

T. Nagano, T. Mashino, M. Hirobe, 2001 .

cAMP-independent mechanism is significantly involved in beta2-adrenoceptor-mediated tracheal relaxation.

T. Horinouchi, Yoshio Tanaka, K. Koike, 2004, European journal of pharmacology.

Interaction of a beta-adrenergic partial agonist with its receptor in guinea-pig taenia caecum.

I. Takayanagi, K. Koike, 1984, General pharmacology.

Relationship between intrinsic activity of beta-adrenoceptor agonist and amount of spare receptors in guinea pig taenia caecum.

I. Takayanagi, K. Koike, 1983, Japanese journal of pharmacology.

Piperazine analog of vesamicol: In vitro and in vivo characterization for vesicular acetylcholine transporter

K. Taguchi, K. Koike, K. Bando, 2000, Synapse.

Comparison of interactions of R(+)- and S(-)-isomers of beta-adrenergic partial agonists, befunolol and carteolol, with high affinity site of beta-adrenoceptors in the microsomal fractions from guinea-pig ciliary body, right atria and trachea.

T. Horinouchi, I. Takayanagi, K. Koike, 1994, General pharmacology.

Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts.

K. Hayashi, T. Kusama, K. Koike, 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscle

K. Shigenobu, T. Horinouchi, Yoshio Tanaka, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of smooth muscle relaxant (aspaminol) on Ca-uptake by mitochondrial and microsomal fractions from rat uterus.

I. Takayanagi, K. Koike, T. Hisayama, 1981, Journal of pharmacobio-dynamics.

Pharmacological characterization of the β-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle

T. Horinouchi, K. Koike, Y. Tanaka, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptors.

T. Horinouchi, K. Koike, Y. Tanaka, 2005, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Evidence showing that β‐adrenoceptor subtype responsible for the relaxation induced by isoprenaline is principally β2 but not β1 in guinea‐pig tracheal smooth muscle

T. Horinouchi, K. Koike, Y. Tanaka, 2004 .

Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle.

M. Matsushita, T. Horinouchi, Yoshio Tanaka, 2003, European journal of pharmacology.

Function of β1-adrenoceptors and mRNA expression of β1- and β2-adrenoceptors in guinea-pig esophagus

T. Horinouchi, K. Koike, Y. Tanaka, 2003 .

Partial Agonistic Properties of (±)-Pindolol at Atypical β-Adrenoceptors in the Guinea Pig Gastric Fundus

T. Horinouchi, K. Koike, 2001, Pharmacology.

Structure-activity relationship studies of (+/-)-terbutaline and (+/-)-fenoterol on beta3-adrenoceptors in the guinea pig gastric fundus.

T. Horinouchi, K. Koike, Y. Nakagawa, 2001, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

(+/-)-Pindolol acts as a partial agonist at atypical beta-adrenoceptors in the guinea pig duodenum.

T. Horinouchi, K. Koike, 2001, Japanese journal of pharmacology.

Further evidence that (+/-)-carteolol-induced relaxation is mediated by beta2-adrenoceptors but not by beta3-adrenoceptors in the guinea pig taenia caecum.

T. Horinouchi, K. Koike, 2000, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Functional identification of beta3-adrenoceptors in the guinea-pig ileum using the non-selective beta-adrenoceptor antagonist (+/-)-bupranolol.

T. Horinouchi, K. Koike, 2000, Journal of autonomic pharmacology.

The beta3-adrenoceptor-mediated relaxation induced by epinephrine in guinea pig taenia caecum.

Y. Yamamoto, T. Horinouchi, K. Koike, 2000, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Pharmacological Analysis of Atypical β-Adrenoceptors in the Guinea Pig Gastric Fundus Using the β3-Adrenoceptor Antagonist Bupranolol

T. Horinouchi, K. Koike, 1999, Pharmacology.

Characterization of atypical β-adrenoceptors in the guinea pig duodenum

T. Horinouchi, K. Koike, 1999 .

Beta3-adrenoceptor mechanisms in guinea-pig taenia caecum.

I. Takayanagi, K. Koike, 1984, Life sciences.

Beta3-adrenoceptors mediate relaxation of guinea pig taenia caecum by BRL37344A and BRL35135A.

I. Takayanagi, K. Koike, T. Nagatomo, 1997, European journal of pharmacology.

The β2 and β3-Adrenoceptor-Mediated Relaxation Induced by Isoprenaline and Salbutamol in Guinea Pig Taenia Caecum

T. Horinouchi, I. Takayanagi, K. Koike, 1997 .

Effect of bupranolol on CGP 12177-induced relaxation and cAMP accumulation in the guinea pig taenia caecum.

T. Horinouchi, I. Takayanagi, K. Koike, 1995, General pharmacology.

Possible mechanisms of beta-adrenoceptor-mediated relaxation induced by noradrenaline in guinea pig taenia caecum.

T. Horinouchi, I. Takayanagi, K. Koike, 1995, European journal of pharmacology.

Signal transduction pathway involved in beta 3-adrenoceptor-mediated relaxation in guinea pig taenia caecum.

T. Horinouchi, I. Takayanagi, K. Koike, 1995, Japanese journal of pharmacology.

Nitric oxide (NO) primarily accounts for endothelium-dependent component of beta-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline.

M. Matsushita, T. Horinouchi, K. Koike, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Synthesis and evaluation of radiolabeled piperazine derivatives of vesamicol as SPECT agents for cholinergic neurons.

K. Taguchi, K. Koike, K. Bando, 2001, Nuclear medicine and biology.

Effects of aging on postsynaptic α1-adrenoceptor mechanisms in rat aorta

I. Takayanagi, K. Koike, 1991 .

Propylbenzilycholine mustard (PrBCM)-sensitive cholinoceptors and contractile response to partial agonist in guinea pig ileal muscle.

K. Saito, M. Satoh, I. Takayanagi, 1991, Japanese journal of pharmacology.

Cyclic AMP-independent relaxation mediated by beta3-adrenoceptors on guinea pig gastrointestine.

T. Horinouchi, K. Koike, 2002, European journal of pharmacology.

Effects of aging on alpha1-adrenoceptor mechanisms in the isolated mouse aortic preparation.

Yoshio Tanaka, K. Koike, Y. Tanaka, 2006, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Effect of SR59230A on Atypical β-Adrenoceptor Mediating Relaxation in the Guinea Pig Gastric Fundus

T. Horinouchi, K. Koike, Y. Yamamoto, 2001, Pharmacology.

Effect of ageing on alpha 1A-adrenoceptor mechanisms in rabbit isolated bronchial preparations.

I. Takayanagi, M. Moriya, K. Koike, 1992, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Postsynaptic α1‐adrenoceptor mechanisms in rat vas deferens and ageing

I. Takayanagi, K. Koike, O. Maeda, 1987 .

Effects of optical isomers of ephedrine and methylephedrine on the twitch response in the isolated rat vas deferens and the involvement of alpha 2-adrenoceptors.

K. Koike, H. Saito, T. Kawasuji, 1996, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Update on angiogenic potential of neural stem cells.

K. Koike, Y. Tanaka, 2004, Journal of pharmacological sciences.

The beta3-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum.

T. Horinouchi, K. Koike, Y. Tanaka, 2003, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Characteristics of [3H]CGP12177 binding sites at β2- and β3-adrenoceptors in the guinea pig taenia caecum

I. Takayanagi, K. Koike, 1997 .

Thrombin‐stimulated proliferation is mediated by endothelin‐1 in cultured rat gingival fibroblasts

K. Hayashi, T. Kakegawa, K. Koike, 2009, Fundamental & clinical pharmacology.

Pharmacological properties of newly synthesized derivatives of (-)-6 beta-acetylthionormorphine and their interactions with opioid receptors.

T. Suzuki, I. Takayanagi, K. Koike, 1990, General pharmacology.

Pharmacological characteristics of indoline derivatives in muscarinic receptor subtypes.

I. Takayanagi, K. Koike, S. Adachi, 1996, Pharmacology.

The Ideal Synthetic Method Aimed at the Leads for an α2-Blocker, an Inhibitor of Blood Platelet Aggregation, and an Anti-osteoporosis Agent

M. Somei, A. Hattori, N. Suzuki, 2006 .

Drug receptor mechanisms in smooth muscle: beta-chloroethylamine-sensitive and -resistant receptor mechanisms.

M. Satoh, I. Takayanagi, K. Koike, 1997, Japanese journal of pharmacology.

Effects of a new positive inotropic agent with a vasodilatory action, 5-methyl-6-(4-pyridyl)-2H-1,4-thiazin-3(4H)-one (ZSY-27), on calcium-movement and mechanical response in rabbit thoracic aorta.

I. Takayanagi, K. Koike, K. Yoshioka, 1989, Journal of pharmacobio-dynamics.

Inhibition of Ca-movement and mechanical movement in rabbit taenia coli by a smooth muscle relaxant (suloctidil).

M. Kaneko, I. Takayanagi, K. Koike, 1981, Journal of pharmacobio-dynamics.

Possible mechanisms of stimulatory action of papaverine on calcium-uptake by rat uterine microsomal fraction.

I. Takayanagi, K. Koike, 1981, Japanese journal of pharmacology.

Effects of nonspecific smooth muscle relaxants on calcium-uptake by microsomal fraction and their inhibitory action in rabbit taenia coli.

I. Takayanagi, K. Koike, Y. Yoshida, 1980, Journal of pharmacobio-dynamics.

Selectivity of cerebral vasodilators on basilar arteries.

I. Takayanagi, K. Koike, K. Yamada, 1986, General pharmacology.

Chronotropic effects of optical isomers of ephedrine and methylephedrine in the isolated rat right atria and in vitro assessment of direct and indirect actions on beta 1-adrenoceptors.

K. Koike, H. Saito, T. Kawasuji, 1996, Biological & pharmaceutical bulletin.

Ca-blocking action of stereoisomers of CI-951, (+)-CI-951 (NC-1500) and (-)-CI-951 in the isolated muscle preparations.

I. Takayanagi, K. Koike, Y. Urita, 1992, General Pharmacology.

Some pharmacological properties of a new antitumor drug, CPT-11, in isolated muscle preparations.

M. Tagawa, I. Takayanagi, K. Koike, 1989, General pharmacology.

Actions of 4-(2-hydroxy-3-[(1-methyl-3-phenylpropyl)amino]propoxy)benzeneacetamide (KF4317) and labetalol on α- and β-adrenoceptors

M. Kusunoki, I. Takayanagi, K. Koike, 1986 .

A difference in alpha-adrenoceptor mechanisms in vasa deferentia isolated from young and old rats.

M. Ishizuka, I. Takayanagi, K. Koike, 1986, Japanese journal of pharmacology.

Effect of aging on presynaptic α2-adrenoceptor mechanisms in guinea pig ileum

I. Takayanagi, K. Koike, O. Maeda, 1989 .

Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method.

S. Morishima, S. Miwa, T. Horinouchi, 2009, Life sciences.

Effect of ageing on response to nicotine in rabbit bronchial preparation.

I. Takayanagi, M. Moriya, K. Koike, 1991, General pharmacology.

A dual action of papaverine on calcium uptake by microsomal fraction isolated from rat uterus.

I. Takayanagi, K. Koike, T. Hisayama, 1981, European journal of pharmacology.

Characterization of subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle.

I. Takayanagi, K. Koike, M. Harada, 1992, Japanese journal of pharmacology.

Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture.

K. Hayashi, T. Kusama, K. Koike, 2002, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Phospholipase C inhibitors suppress spontaneous mechanical activity of guinea pig urinary bladder smooth muscle.

K. Shigenobu, Hikaru Tanaka, T. Horinouchi, 2003, Biological & pharmaceutical bulletin.

Pharmacological properties of acetylcholine receptor in molluscan smooth muscle.

I. Takayanagi, K. Koike, Y. Ishii, 1983, Japanese journal of pharmacology.

Relationship between sensitivity and density of muscarinic receptors in single smooth muscle cells of guinea pig taenia caecum prepared under three conditions.

I. Takayanagi, K. Koike, H. Ohtsuki, 1990, Canadian journal of physiology and pharmacology.

Interactions of muscarinic drugs with their receptors in single cells of guinea‐pig taenia caecum

I. Takayanagi, K. Koike, T. Hiruta, 1986, The Journal of pharmacy and pharmacology.

Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p and sodium ion on the affinity of dynorphin 1-13, nalorphine and nalorphine-7,8-oxide to kappa-opioid receptor.

M. Hirobe, I. Takayanagi, K. Koike, 1985, General pharmacology.

Interaction of newly synthesized N-cyclopropylmethyl derivatives of (-)-6 beta-acetylthionormorphine with opioid receptors.

T. Mori, K. Kanematsu, I. Takayanagi, 1990, General pharmacology.

H₂receptor-mediated positive inotropic effect of histamine in neonatal guinea-pig left atria.

Iyuki Namekata, Hikaru Tanaka, A. Takahara, 2010, Biological & pharmaceutical bulletin.

MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms.

L. Toro, Yoshio Tanaka, K. Koike, 2004, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Design and synthesis of affinity labeling peptide inhibitors to receptors or proteases

H. Umeyama, I. Takayanagi, K. Koike, 1993 .

Histopathological study of kidney abnormalities in an experimental SIADH rat model and its application to the evaluation of the pharmacologic profile of VP-343, a selective vasopressin V2 receptor antagonist.

T. Kurasawa, H. Hasegawa, K. Shigenobu, 2001, Biological & pharmaceutical bulletin.

Pharmacological profile of VP-343, a novel selective vasopressin V2 receptor antagonist, in rats.

T. Kurasawa, K. Shigenobu, H. Tanaka, 2000, Biological & pharmaceutical bulletin.

Partial agonistic activity of labetalol, the arylethanolamine, on beta 3-adrenoceptors in the guinea-pig gastric fundus.

T. Horinouchi, M. Fukushima, K. Koike, 2002, Autonomic & autacoid pharmacology.

New insights into beta-adrenoceptors in smooth muscle: distribution of receptor subtypes and molecular mechanisms triggering muscle relaxation.

T. Horinouchi, Yoshio Tanaka, K. Koike, 2005, Clinical and experimental pharmacology & physiology.

The β2-and β3-Adrenoceptor-Mediated Relaxation Induced by Fenoterol in Guinea Pig Taenia Caecum

T. Horinouchi, K. Koike, Y. Tanaka, 2002 .

Further characterization of β3-adrenoceptors in the guinea pig gastric fundus: stereoselectivity, β-adrenoceptor alkylation, and structure-activity relationship

T. Horinouchi, K. Koike, 2001 .

Functional properties of atypical β-adrenoceptors on the guinea pig duodenum

T. Horinouchi, K. Koike, 2001 .

Evidence for the primary role for 4-aminopyridine-sensitive Kv channels in β3-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles

T. Horinouchi, Yoshio Tanaka, K. Koike, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

The beta2- and beta3-adrenoceptor-mediated relaxation induced by fenoterol in guinea pig taenia caecum.

T. Horinouchi, K. Koike, Y. Tanaka, 2002, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Partial agonist activity of carteolol on atypical beta-adrenoceptors in the guinea pig duodenum.

T. Horinouchi, K. Koike, 2000, European journal of pharmacology.

Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus.

T. Horinouchi, K. Koike, 2000, Japanese journal of pharmacology.

Role of BK channels in testosterone-induced relaxation of the aorta in spontaneously hypertensive rats.

H. Kogo, K. Tamura, M. Matsushita, 2007, Biological & pharmaceutical bulletin.

Effects of the R(+)- and S(-)-isomers of beta-adrenoceptor blockers with intrinsic sympathomimetic activity, befunolol and carteolol, on rabbit intraocular pressure.

Y. Kasuya, I. Takayanagi, K. Koike, 1991, Canadian journal of physiology and pharmacology.

A possible mechanism of action of a beta-adrenergic partial agonist (carteolol) in guinea pig taenia caecum.

I. Takayanagi, K. Koike, 1983, Journal of Pharmacobio-Dynamics.

Differentiation of binding sites of CGP12177, aβ3-adrenoceptor partial agonist, and carteolol, a β1/β2-adrenoceptor partial agonist, to the β-adrenoceptors in guinea-pig taenia caecum

I. Takayanagi, K. Koike, M. Yamazaki, 1996 .

TRANSITION OF DRUG RESEPTOR MECHANISMS

M. Satoh, I. Takayanagi, K. Koike, 1992 .

Thermodynamic analysis of beta-adrenergic partial agonists (befunolol and carteolol) interaction with low and high affinity binding sites of beta-adrenoceptors in guinea-pig taenia caecum.

I. Takayanagi, K. Koike, M. Ogishima, 1990, General pharmacology.

Stereoselectivity in beta-adrenomimetic and beta-adrenolytic actions of carteolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic action in guinea-pig taenia caecum.

I. Takayanagi, K. Koike, H. Hagiwara, 1990, General pharmacology.

Dose difference in β-adrenergic blockers with intrinsic sympathomimetic action to block β-adrenoceptors and induce sympathomimetic action

I. Takayanagi, K. Koike, T. Hisayama, 1989 .

Effect of histamine on two different affinity sites in β-adrenoceptors

I. Takayanagi, K. Koike, M. Fujii, 1989 .

Interactions of befunolol, a beta-adrenergic partial agonist, and its derivatives with high and low affinity sites in beta-adrenoceptors.

I. Takayanagi, K. Koike, 1987, Journal of pharmacobio-dynamics.

A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites.

I. Takayanagi, K. Koike, 1986, Japanese journal of pharmacology.

A possible mechanism in interaction of a partial agonist with beta-adrenoceptor in guinea-pig taenia caecum: effects of Gpp(NH)p on its two different binding sites.

I. Takayanagi, K. Koike, 1985, Japanese journal of pharmacology.

Interaction of muscarinic drugs with their receptor.

I. Takayanagi, K. Koike, K. Okumura, 1985, General pharmacology.

A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs.

I. Takayanagi, K. Koike, 1985, General pharmacology.

Interactions of some partial agonists with beta-adrenoceptor in the isolated taenia caecum and tracheal smooth muscle of guinea pig.

I. Takayanagi, K. Koike, Takahiro Sato, 1984, Japanese journal of pharmacology.

Intrinsic activity and effects of guanyl-5'-yl imidodiphosphate, Gpp(NH)p on the affinity of partial agonists to the muscarinic receptor.

I. Takayanagi, K. Koike, K. Okumura, 1984, European journal of pharmacology.

MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms

L. Toro, K. Shigenobu, Hikaru Tanaka, 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differences of antagonism for a selective alpha1D-adrenoceptor antagonist BMY 7378 in the rabbit thoracic aorta and iliac artery.

K. Enomoto, M. Satoh, I. Takayanagi, 1998, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

Pharmacological characterization of alpha1-adrenoceptor in mouse iliac artery.

T. Horinouchi, Yoshio Tanaka, K. Koike, 2002, European Journal of Pharmacology.

Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol.

S. Morishima, S. Miwa, T. Horinouchi, 2007, Life sciences.

Differences in alpha 1-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery.

M. Satoh, I. Takayanagi, K. Koike, 1991, Canadian journal of physiology and pharmacology.

α1‐Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta

K. Koike, Yoshihisa Yamamoto, 2001, British journal of pharmacology.

Correlation between vasoconstrictor roles and mRNA expression of α1‐adrenoceptor subtypes in blood vessels of genetically engineered mice

G. Tsujimoto, C. Hosoda, T. Koshimizu, 2005, British journal of pharmacology.

Antagonistic effects of selective α1‐adrenoceptor antagonists MDL73005EF and tamsulosin and partial agonists clonidine and tizanidine in rat thoracic aorta and rabbit iliac artery

M. Satoh, K. Koike, Keisuke Enomoto, 2001, The Journal of pharmacy and pharmacology.

Alpha1-adrenoceptors are required for normal male sexual function.

G. Tsujimoto, A. Tanoue, A. Sanbe, 2007, British Journal of Pharmacology.

A difference in receptor mechanisms for muscarinic full and partial agonists.

I. Takayanagi, K. Koike, M. Harada, 1991, Japanese journal of pharmacology.

Propylbenzilylcholine mustard-sensitive and -resistant muscarinic receptors in cardiac muscle.

K. Saito, I. Takayanagi, K. Koike, 1991, General pharmacology.

Comparison of the inhibitory effects of docosahexaenoic acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig aorta.

K. Shigenobu, Hikaru Tanaka, K. Koike, 2005, Biological & pharmaceutical bulletin.

Relaxant responses by optical isomers of ephedrine and methylephedrine in guinea pig tracheal smooth muscle.

M. Matsumoto, N. Yasuda, I. Takayanagi, 1996, Pharmacology.

Original β 1-Adrenoceptor-mediated relaxation with isoprenaline and the role of MaxiK channels in guinea-pig esophageal smooth muscle

T. Horinouchi, K. Koike, Y. Tanaka, 2004 .

Vascular relaxing mechanism of denopamine in isolated canine coronary, femoral, mesenteric, and renal arteries

M. Moroi, K. Machii, A. Namiki, 2005, Heart and Vessels.

Inhibition of angiotensin II‐ and endothelin‐1‐stimulated proliferation by selective MEK inhibitor in cultured rabbit gingival fibroblasts †

K. Hayashi, K. Koike, Y. Kizawa, 2005, Fundamental & clinical pharmacology.

Agonistic activity of SR59230A at atypical beta-adrenoceptors in guinea pig gastric fundus and duodenum.

T. Horinouchi, K. Koike, Katsuo Koike, 2001, European journal of pharmacology.

Effects of aging on postsynaptic alpha 1-adrenoceptor mechanisms in rat aorta.

I. Takayanagi, K. Koike, 1991, General pharmacology.

[Beta 3-adrenoceptor-mediated relaxation of guinea-pig gastric funds smooth muscle: cAMP-independent characteristics and a primary role of 4-aminopyridine-sensitive voltage-dependent K+ (Kv) channels].

T. Horinouchi, Yoshio Tanaka, K. Koike, 2002, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK channel.

L. Toro, Yoshio Tanaka, K. Koike, 2004, Current medicinal chemistry. Cardiovascular and hematological agents.

Thrombin‐stimulated proliferation is mediated by endothelin‐1 in cultured rat gingival fibroblasts

K. Hayashi, T. Kakegawa, K. Koike, 2009, Fundamental & clinical pharmacology.

Characterization of muscarine receptors in rabbit ciliary body smooth muscle using propylbenzilylcholine mustard.

K. Saito, M. Satoh, I. Takayanagi, 1991, General pharmacology.

Anti-leukotriene D4 action of a new anti-asthmatic drug (KC-404) on the guinea-pig isolated trachea.

I. Takayanagi, K. Koike, H. Nagai, 1986, General pharmacology.