Yoshiaki Kobayashi

Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets

M. Aida, K. Ui-Tei, Tomoko Takahashi, 2017, ACS omega.

Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo

K. Ui-Tei, H. Taniguchi, Yoshimasa Asano, 2022, Cancers.

A 2'-modified uridine analog, 2'-O-(methylthiomethoxy)methyl uridine, for siRNA applications.

K. Ui-Tei, Zhaoma Shu, Naoko Abe, 2022, Bioorganic & medicinal chemistry letters.

The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects

K. Ui-Tei, Yoshiaki Kobayashi, Shen Tian, 2022, Genes.

siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications

M. Aida, K. Ui-Tei, Dai Akase, 2022, ACS omega.

A robust model for quantitative prediction of the silencing efficacy of wild-type and A-to-I edited miRNAs

K. Asai, K. Ui-Tei, G. Terai, 2020, RNA biology.

Selection of Chemical Modifications in the siRNA Seed Region That Repress Off-Target Effect.

M. Aida, K. Ui-Tei, Kengo Miyamoto, 2021, Methods in molecular biology.