L. McAlary

发表

Investigations into the Unfolding, Misfolding, and Aggregation of Superoxide Dismutase-1 using Native Mass Spectrometry

L. McAlary, Luke McAlary, 2017 .

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

C. Wellington, N. Cashman, T. Caffrey, 2020, Molecular Neurodegeneration.

A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

J. Yerbury, Gareth S. A. Wright, L. McAlary, 2022, The Journal of biological chemistry.

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

J. Aquilina, J. Yerbury, L. McAlary, 2016, Frontiers in neuroscience.

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

D. Saunders, K. Vine, Jeremy S. Lum, 2020, iScience.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

D. Saunders, K. Vine, J. Yerbury, 2018, Journal of Cell Science.

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

J. Yerbury, L. McAlary, 2019, Neural regeneration research.

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

J. Aquilina, J. Yerbury, L. McAlary, 2013, Scientific Reports.

Protein Aggregation in Amyotrophic Lateral Sclerosis

J. Yerbury, L. McAlary, Christen G. Chisholm, 2021, Spectrums of Amyotrophic Lateral Sclerosis.

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding.

S. Plotkin, J. Yerbury, L. McAlary, 2018, ACS chemical neuroscience.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

Mark R. Wilson, J. Kumita, J. Yerbury, 2017, Prion.

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

K. Schroder, T. Woodruff, Eduardo A. Albornoz, 2020, Glia.

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

J. Julien, S. Plotkin, S. Pozzi, 2020, bioRxiv.

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Jacob I. Ayers, D. Borchelt, N. Cashman, 2020, PloS one.

In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo

S. Plotkin, P. Garg, N. Cashman, 2018, bioRxiv.

Assessment of protein inclusions in cultured cells using automated image analysis

S. Plotkin, N. Cashman, J. Yerbury, 2022, STAR protocols.

The trajectory taken by dimeric Cu/Zn superoxide dismutase through the protein unfolding and dissociation landscape is modulated by salt-bridge formation.

J. Benesch, J. Aquilina, J. Yerbury, 2019, Analytical chemistry.

Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma

Jonathan R. Clark, M. Carolan, M. Tehei, 2020, Physics in medicine and biology.

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

N. Cashman, J. Yerbury, Neil R Cashman, 2018, Scientific Reports.

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

S. Plotkin, N. Cashman, J. Yerbury, 2019, Front. Mol. Neurosci..

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

Yee Lian Chew, Jeremy S. Lum, N. Cashman, 2020, Frontiers in Cellular Neuroscience.

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

L. Foster, I. Mackenzie, C. Cowan, 2019, The Journal of Biological Chemistry.

The prion-like nature of amyotrophic lateral sclerosis.

N. Cashman, J. Yerbury, L. McAlary, 2020, Progress in molecular biology and translational science.

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

S. Plotkin, N. Cashman, L. McAlary, 2019, CNS Drugs.

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

C. Wellington, N. Cashman, T. Caffrey, 2020, Molecular Neurodegeneration.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

M. Wilson, H. Ecroyd, J. Yerbury, 2016, Scientific Reports.

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

J. Yerbury, L. McAlary, N. Farrawell, 2020, Trends in Neurosciences.

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

S. Antonyuk, S. Hasnain, L. Banci, 2018, Nature Communications.

Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity.

Jeremy S. Lum, J. Yerbury, L. McAlary, 2022, ACS chemical neuroscience.

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background

P. Crouch, K. Vine, Jeremy S. Lum, 2021, Scientific Reports.

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

D. Cox, A. Walker, H. Ecroyd, 2020, Journal of Cell Science.

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

S. Plotkin, N. Cashman, J. Yerbury, 2020, Frontiers in Molecular Neuroscience.

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.

D. Saunders, I. Blair, L. Ooi, 2023, Human Molecular Genetics.

Protocol for the generation and automated confocal imaging of whole multi-cellular tumor spheroids

M. Ranson, B. Ashford, L. McAlary, 2023, STAR Protocols.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

J. Yerbury, P. Ciryam, J. McKenna, 2017, bioRxiv.

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

H. Ecroyd, J. Yerbury, L. McAlary, 2016, Scientific Reports.