K. van Emelen

发表

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

M. Janicot, M. Jung, D. Johnson, 2007, British Journal of Cancer.

Histone deacetylase inhibitors: from chromatin remodeling to experimental cancer therapeutics.

J. Arts, S. de Schepper, K. van Emelen, 2003, Current medicinal chemistry.

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Bioorganic & medicinal chemistry letters.

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.

J. Wegner, B. Samuelsson, L. Baert, 2013, Bioorganic & medicinal chemistry letters.

CXCR4 as a novel target in immunology: moving away from typical antagonists

Armelle Melet, J. Herbeuval, A. Van der Aa, 2022, Future drug discovery.

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.

M. Janicot, L. van Hijfte, H. De Winter, 2005, European journal of medicinal chemistry.

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

M. Janicot, M. Noppe, L. van Hijfte, 2010, Bioorganic & medicinal chemistry letters.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

M. Cummings, Lili Hu, F. Pauwels, 2009, Bioorganic & medicinal chemistry letters.

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

B. Samuelsson, M. Cummings, Christophe Buyck, 2010, Journal of Medicinal Chemistry.

Diastereoselective intramolecular Ritter reaction: generation of a cis-fused hexahydro-4aH-indeno[1,2-b]pyridine ring system with 4a,9b-diangular substituents.

T. de Wit, F. Compernolle, K. van Emelen, 2000, Organic letters.

JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity

W. Talloen, I. Hickson, M. Janicot, 2009, Clinical Cancer Research.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.

M. Cummings, Lili Hu, O. Nyanguile, 2012, Bioorganic & medicinal chemistry letters.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.