P. O'hanlon

发表

H. Ferres, M. Basker, D. J. Best, 1978 .

Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives.

P. O'hanlon, R. M. Banks, A. Donald, 1988, The Journal of antibiotics.

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207.

A. K. Forrest, C. Easton, C. Crasto, 2003, Bioorganic & medicinal chemistry.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

A. K. Forrest, R. Sheppard, Murray J. B. Brown, 2003, Bioorganic & medicinal chemistry letters.

Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

James R. Brown, M. Stanhope, D. Holmes, 2003, Antimicrobial Agents and Chemotherapy.

The chemistry of Pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles.

D. Davies, P. Brown, J. Wilson, 1996, Journal of medicinal chemistry.

The chemistry of pseudomonic acid. Part 12. Preparation of diazole and triazole derivatives

A. K. Forrest, G. Walker, P. O'hanlon, 1994 .

New methodology for the synthesis of unsaturated 8-, 9- and 10-membered lactams

A. Nadin, P. Evans, A. Holmes, 1996 .

Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A.

N. Broom, R. Cassels, P. O'hanlon, 1999, Bioorganic & medicinal chemistry letters.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

A. K. Forrest, R. Sheppard, A. Fosberry, 2005, Bioorganic & medicinal chemistry letters.

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

A. Pope, D. Hamprecht, P. Brown, 2001, Bioorganic & medicinal chemistry letters.

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

A. Fosberry, A. Pope, P. Milner, 2002, Bioorganic & medicinal chemistry letters.

The Chemistry of Pseudomonic Acid.† 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity1

N. F. Osborne, T. Mitchell, P. Brown, 1997 .

The preparation and lithiation of bromofluorofurans via a novel fluorodecarboxylation

A. K. Forrest, P. O'hanlon, 1995 .

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

A. Pope, D. Eggleston, R. Haltiwanger, 2001, Bioorganic & medicinal chemistry letters.

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

A. K. Forrest, Murray J. B. Brown, R. Copley, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

A. Pope, S. Rittenhouse, L. Mensah, 2000, The Journal of antibiotics.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

A. Pope, D. Eggleston, R. Copley, 2000, Bioorganic & medicinal chemistry letters.

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.

N. F. Osborne, A. Pope, C. Richardson, 1999, Bioorganic & medicinal chemistry.

The chemistry of pseudomonic acid. Part 5. Structure and chemistry of pseudomonic acid C. X-Ray crystal structure of ethyl monate C

T. King, P. O'hanlon, N. H. Rogers, 1983 .

The chemistry of pseudomonic acid. Part 10. Preparation of heterocyclic derivatives

G. Walker, P. O'hanlon, N. H. Rogers, 1989 .

Structure-activity dependency of new bacterial tryptophanyl tRNA synthetase inhibitors

G. Walker, R. Cassels, J. Bateson, 1996 .

The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.

G. Walker, J. Wilson, N. Broom, 1995, The Journal of antibiotics.

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.

G. Hervieu, A. Muir, K. Thewlis, 2006, Bioorganic & medicinal chemistry letters.

The preparation of derivatives containing the imidazo[2,1-b]thiazine and 1,2,4-triazolo[3,2-b][1,3]thiazine systems

T. King, P. O'hanlon, J. P. Clayton, 1980 .

Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

T. Gallagher, J. Bateson, P. O'hanlon, 2005 .

The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.

G. Walker, J. Wilson, N. Broom, 1995, The Journal of antibiotics.

S-alkyl dithioformates as 1,3-dipolarophiles. Generation of C(2)-unsubstituted penems.

T. Gallagher, J. Bateson, P. O'hanlon, 2004, Organic letters.

Anti-infectives: recent advances in chemistry and structure-activity relationships. The Proceedings of the 2nd International Symposium on Recent Advances in the Chemistry of Anti-infective Agents held at Churchill College, Cambridge, UK, 7-10 July 1996.

P. Bentley, P. O'hanlon, 1997 .

The chemistry of pseudomonic acid, part II. Dehydrative cyclisation of α-acylamino ketones to oxazoles

G. Walker, P. O'hanlon, N. H. Rogers, 1989 .

Analogues of SB-203207 as inhibitors of tRNA synthetases.

A. K. Forrest, C. Easton, C. Crasto, 2000, Bioorganic & medicinal chemistry letters.

A versatile approach to the total synthesis of the pseudomonic acids

A. K. Forrest, T. J. Simpson, C. Willis, 2000 .

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

A. Pope, L. Mensah, R. L. Jarvest, 2001, Bioorganic & medicinal chemistry letters.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

A. K. Forrest, H. Boyd, R. Sheppard, 2002, Journal of medicinal chemistry.

Synthetic and biosynthetic studies of porphyrins. Part 2. Synthesis of isopempto- and isochlorocruoro-porphyrins.

D. E. Games, P. O'hanlon, A. Jackson, 1976, Journal of the Chemical Society. Perkin transactions 1.

Isocoproporphyrin: nuclear-magnetic-resonance-and mass-spectral methods for the determination of porphyrin structure.

D. Millington, G. Elder, D. E. Games, 1973, The Biochemical journal.

Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin

D. Eggleston, R. Haltiwanger, G. Walker, 1996 .

Advances in the chemistry of novel broad-spectrum orally active azole antifungals: recent studies leading to the discovery of SCH 56592.

W. Haiyan, A. Cooper, J. Desai, 1997 .

Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin

I. Chopra, A. O’Neill, Ian Chopra, 2001, Antimicrobial Agents and Chemotherapy.

In vitro evaluation of various quinolone antibacterial agents against veterinary mycoplasmas and porcine respiratory bacterial pathogens.

P. O'hanlon, P. Hannan, N. H. Rogers, 1989, Research in veterinary science.

SB 205952, a novel semisynthetic monic acid analog with at least two modes of action

I. Chopra, J. Wilson, B. Oliva, 1995, Antimicrobial agents and chemotherapy.

Beta-lactam antibiotics. I. Comparative structure--activity relationships of 6-acylaminopenicillanic acid derivatives and their 6-(D-alpha-acylaminophenylacetamido) penicillanic acid analogues.

H. Ferres, M. Basker, P. O'hanlon, 1974, The Journal of antibiotics.

The preparation of 2-(heterocyclyl)thikno[3,2-b]pyridine derivatives

R. Elliott, P. O'hanlon, N. H. Rogers, 1987 .

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.

G. Hervieu, Shelagh Wilson, A. Muir, 2006, Bioorganic & medicinal chemistry letters.

Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors.

A. West, A. Pope, J. Humphries, 2003, European journal of medicinal chemistry.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

A. Pope, S. Rittenhouse, P. Brown, 2003, Bioorganic & medicinal chemistry letters.

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

A. K. Forrest, M. Doyle, A. Pope, 2000, Biochemistry.

The chemistry of pseudomonic acid. Part 6. Structure and preparation of pseudomonic acid D

J. Tyler, P. O'hanlon, N. H. Rogers, 1984 .

The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity.

N. F. Osborne, T. Mitchell, P. Brown, 1997, Journal of medicinal chemistry.

The chemistry of pseudomonic acid

S. Coulton, P. O'hanlon, N. H. Rogers, 1987 .

Seven-Membered Lactams as Constraints for Amide Self-Recognition

J. Goodman, A. Nadin, A. Holmes, 1995 .

Seven‐Membered Lactams as Constraints for Amide Self‐Recognition.

J. Goodman, A. Nadin, A. Holmes, 1996 .

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

C. Janson, A. Pope, A. Saldanha, 1999, Bioorganic & medicinal chemistry letters.