J. Schaus

发表

Preclinical Pharmacology of FMPD [6-Fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene]: A Potential Novel Antipsychotic with Lower Histamine H1 Receptor Affinity Than Olanzapine

Todd R. Wiernicki, F. Bymaster, L. Nisenbaum, 2005, Journal of Pharmacology and Experimental Therapeutics.

Rapid assessment of conformational preferences in biaryl and aryl carbonyl fragments

J. Schaus, Sonia Maria Gutiérrez Sanfeliciano, 2018, PloS one.

Substituted furo[3,2-b]pyridines: novel bioisosteres of 5-HT 1F receptor agonists.

T. Branchek, J. Zgombick, W. Gough, 2004, Bioorganic & medicinal chemistry letters.

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties

J. Zgombick, J. Krushinski, D. Nelson, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological characterization of the cannabinoid CB₁ receptor PET ligand ortholog, [³H]MePPEP.

T. Suter, M. Statnick, J. Krushinski, 2010, European journal of pharmacology.

Evaluation of an inverse agonist with high affinity for the CB1 receptor, [11C]MePPEP, in rodents and humans

Garth E. Terry, C. Halldin, S. Zoghbi, 2008, NeuroImage.

Radiolabeling of a high potency cannabinoid subtype‐1 receptor ligand, N‐(4‐fluoro‐benzyl)‐4‐(3‐(piperidin‐1‐yl)‐indole‐1‐sulfonyl)benzamide (PipISB), with carbon‐11 or fluorine‐18

Sean R. Donohue, S. Hitchcock, C. Halldin, 2008 .

Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?

Thomas J. Raub, Stuart Morton, C. Mitch, 2014, ACS chemical neuroscience.

A general method for -hydroisoquinoline synthesis

D. Torney, P. Wender, J. Schaus, 1979 .

Dopamine receptors labelled by [3H]quinpirole.

P. Seeman, J. Schaus, 1991, European journal of pharmacology.

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain

J. Krushinski, D. Nelson, J. Audia, 2005, Naunyn-Schmiedeberg's Archives of Pharmacology.

Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides.

Kirk W. Johnson, T. Branchek, J. Zgombick, 2003, Journal of medicinal chemistry.

GENERAL METHODOLOGY FOR CIS‐HYDROISOQUINOLINE SYNTHESIS: SYNTHESIS OF RESERPINE

P. Wender, A. White, J. Schaus, 2002 .

Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.

D. Wong, P. Ornstein, J. Deeter, 1989, Journal of medicinal chemistry.

Oxidation of indolines with Fremy's salt: A mechanistic proposal

J. Schaus, Giethlen Bruno, 1997 .

Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives.

D. Thompson, M. Cohen, W. Bloomquist, 1998, Journal of medicinal chemistry.

Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.

Victor W. Pike, Christer Halldin, Amy K. Chesterfield, 2008, Journal of medicinal chemistry.

[3H]-quinelorane binds to D2 and D3 dopamine receptors in the rat brain.

D. Gehlert, S L Gackenheimer, J M Schaus, 1995, The Journal of pharmacology and experimental therapeutics.

Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.

Sean R. Dinn, W. Gough, J. Krushinski, 2004, Bioorganic & medicinal chemistry letters.

N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.

J. Zgombick, D. Nelson, J. Audia, 2001, Journal of medicinal chemistry.

General methodology for cis-hydroisoquinoline synthesis. III: A sixteen step synthesis of reserpine

P. Wender, A. White, J. Schaus, 1987 .

General methodology for cis-hydroisoquinoline synthesis: synthesis of reserpine

P. Wender, A. White, J. Schaus, 1980 .

SYNTHESIS OF THE DOPAMINE AGONIST (-)-QUINPIROLE

J. Schaus, R. Titus, D. L. Huser, 1990 .

Chapter 1 - Dopaminergic Approaches to Antipsychotic Agents

F. Bymaster, J. Schaus, 1998 .

Aporphines as antagonists of dopamine D-1 receptors.

N. Mason, J. Schaus, L. Truex, 1990, Journal of medicinal chemistry.

The role of 5-HT1A receptors in control of lower urinary tract function in cats

K. Thor, H. Danuser, M. Katofiasc, 2002, Brain Research.

Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents

Jeih-San Liow, Christer Halldin, Garth E. Terry, 2008, NeuroImage.

The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Christer Halldin, Fumihiko Yasuno, Eyassu Chernet, 2008, Neuropsychopharmacology.

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Todd R. Wiernicki, Charles R. Yang, T. Suter, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors

Christian C. Felder, Bin Liu, John M. Schaus, 2006, Cellular and Molecular Neurobiology.

Identification of a high-affinity binding site involved in the transport of endocannabinoids.

G. Nomikos, S. A. Moore, S. Iyengar, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders

Hong Wang, Charles R. Yang, M. O'Neill, 2018, Neuropharmacology.

Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.

Ben Grayson, John M Schaus, F. Bymaster, 2010, The international journal of neuropsychopharmacology.

A general method for cis-hydroisoquinoline synthesis

D. Torney, P. Wender, J. Schaus, 1979 .

Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.

John M Schaus, D. Wong, J. Krushinski, 2007, Bioorganic & medicinal chemistry letters.

Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography

Jeih-San Liow, Cheryl L. Morse, Robert B. Innis, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

Jeih-San Liow, Cheryl L. Morse, Robert B. Innis, 2009, NeuroImage.

Autoradiographic localization of [3H]quinpirole binding to dopamine D2 and D3 receptors in rat brain.

P. Seeman, D. Gehlert, P Seeman, 1992, European journal of pharmacology.

Chapter 5. Dopamine Receptors and Dopaminergic Agents

J. Clemens, J. Schaus, 1985 .

Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor

Charles R. Yang, Y. Qian, B. Heinz, 2018, Molecular Pharmacology.

Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation.

D. Nelson, L. Phebus, K. Johnson, 1998, European journal of pharmacology.

5‐HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs

Kirk W. Johnson, T. Branchek, J. Zgombick, 1997, Neuroreport.

Imaging and Quantitation of Cannabinoid CB1 Receptors in Human and Monkey Brains Using 18F-Labeled Inverse Agonist Radioligands

Jeih-San Liow, Cheryl L. Morse, Robert B. Innis, 2010, Journal of Nuclear Medicine.

Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters.

R. Innis, R. Baldwin, Y. Zea‐Ponce, 1997, Nuclear medicine and biology.

Pharmacological characterization of enantiomers of 8‐thiomethyl‐2‐(di‐n‐propylamino)tetralin, potent and selective 5‐HT1A receptor agonists

J. Barrett, D. Wong, R. Fuller, 1995 .

Stereochemical effects in the reactions of n-alkyl-4-substituted azetidine 2-carboxylic acids with oxalyl chloride. Rearrangement to chloro-γ-lactams.

H. Wasserman, J. Schaus, J. W. Faller, 1984 .

Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT₁ F receptor agonists: Evolution from bicyclic to monocyclic cores.

John M Schaus, Maria-Jesus Blanco, Joseph Krushinski, 2015, Bioorganic & medicinal chemistry letters.